Protein Alignment plx and Tbc1d21

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_083130.1
• Gene: Tbc1d21 / 74286
• MGIID: 1921536
• Length: 336
• Species: Mus musculus
• Alignment Length: 289
• Identity: 66/289 - (22%)
• Similarity: 110/289 - (38%)
• Gaps: 62/289 - (21%)

  Fly   900 PCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTA-----P 959
            |.||   ..|:...:.|. .:...:| .:..:.:..|:....|.:.|.||...:|..::     .
Mouse    26 PIDK---AEWDSFFDENG-HLAKSRD-FICINILERGLHPFVRTEAWKFLTGYYSWQSSRDERLM 85

  Fly   960 VDTKRFPNFNTPYHM------LLKHL----TEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNL 1014
            ||:.|..|:|:...|      ||::|    ||.::.|..|:.|.:.     |||||       |:
Mouse    86 VDSNRRRNYNSLCQMYEKIQPLLENLHGNFTETRNNIAYDIQRLYD-----KDPLG-------NV 138

  Fly  1015 LKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLS 1079
            |.....|:..|    .|.::|.....:....:...:|..||...:..|.:|   .:|.||..:.|
Mouse   139 LIDKKKLEKTL----LLSYVCNTKAEYQRGFHEMVMLFQLMVEHDHETFWL---FQFFLQKTEHS 196

  Fly  1080 RLVK-------DHLPDLYVWLDQ----------NDVSPTLYAAPWILTVFSSQF-PLGFVARVFD 1126
            .::.       |.|..|...||.          :....:|:  ||....|...| ....|.|:::
Mouse   197 CVINIGVGKNLDMLNSLITLLDPEFAEHLKGKGSGAVQSLF--PWFCLCFQRAFKTFDDVWRLWE 259

  Fly  1127 LLFLESSDVIFKFAIA---LLSVHKQQLL 1152
            :|........|:..:|   |..|.:|.||
Mouse   260 VLLTGKPCRNFQVLVAYSMLQMVREQALL 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365
		TBC	933..1152	CDD:214540	58/254 (23%)
		COG4372	<1190..>1353	CDD:443500
Tbc1d21	NP_083130.1	TBC	62..287	CDD:214540	57/245 (23%)