Protein Alignment plx and tbc1d2b

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_012822167.2
• Gene: tbc1d2b / 734055
• XenbaseID: XB-GENE-5932742
• Length: 944
• Species: Xenopus tropicalis
• Alignment Length: 940
• Identity: 182/940 - (19%)
• Similarity: 319/940 - (33%)
• Gaps: 300/940 - (31%)

  Fly   388 KGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQ-------IELGHK- 444
            |.|.|:|     ||.|:.:..|.........|...|..|..:..:||..|:       .||..|
 Frog    69 KHHQDAQ-----PLGQIDIGDASFSYDLEAEEGQFEIHSAGRVSILRAPSRHAMTYWLQELQQKR 128

  Fly   445 -EHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIPKQRDRS 508
             |:.:....|...|       ::|     |....|..|..:..:......||  :::..:.|::.
 Frog   129 WEYCNSFGALKRES-------VIN-----PASTKVPIGLVARESPDYMGIPN--INDAERARNQF 179

  Fly   509 ASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDVASC---VHGQKSLDHFGIICR 570
            |.:.|  |.|..::|.......      :|...||||.:...|:.|.   :...||.|     ||
 Frog   180 AVETC--PSVLGDQTSAEQASN------NPAAVQVLLRQWSNDIRSSMQHLRPGKSSD-----CR 231

  Fly   571 ELNNDGYIGYVFKCQSE----------------HVCDDIVAAIAQAFDTCAEQKKKQDTQ----- 614
            :        ..|....|                ||                 :|:|..|:
 Frog   232 K--------STFYTNEEWELLNPTPKELEESLLHV-----------------EKRKPPTEGIKGS 271

  Fly   615 ------IFSCEHCPMLWYHKLCTDVEGLSEKKTQALI------LRRIET-----LSDDEQEIVWA 662
                  .|.....|......| .::.|:::.:|:.|.      ..|:|:     |...|:|:
 Frog   272 TAGMSFPFDFGRIPQRARRPL-REIMGVNKNRTECLADSLPVSDSRMESDVLLKLQSQEEEL--- 332

  Fly   663 KFCGSEKTNSPVAEQNQFLMML---LRA----------HCESRQQRHVHDTAENRSEFLNQYLGG 714
                 |:....:..|.:.:.:|   ||:          .|:...:.|:|
 Frog   333 -----ERLKKDLLSQKELVRLLQQSLRSSQYDKYFASPFCDGLSKEHLH---------------- 376

  Fly   715 STIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGAS 779
               .::.|.:.....::||:|:..:.|     |..:::.|                       ..
 Frog   377 ---LLQQKDTQIQELNHLLERQTLEKD-----HLHQEVEE-----------------------LK 410

  Fly   780 PSSKPTAEQLKSPMM------DIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTE-- 836
            .|.|...:||...|.      ::.:::.....:.|.|             |||..:.:|:|..
 Frog   411 CSVKELKDQLNMMMETIQAKDEVIMRLSRQLSKYEQH-------------TPSSTVAAEIPVAPQ 462

  Fly   837 --------------------------FLSPMRKPAKRGKRDAAELR------ELWRTAIRQTIML 869
                                      .||.:|:.|:|.:|: .|.|      ::.:...:..::|
 Frog   463 LEELNRLQDSLQGYKAQNTFLNKEILELSALRRNAERRERE-MEARYSNLEAKMCQIESKYLVLL 526

  Fly   870 NRMET------------------------ENA---------------------MLQARQNENELK 889
            ..|:|                        |||                     ::....:|.|.|
 Frog   527 QEMKTPVCSDDQGTAREFVNQLLEDALKVENAEQPEHTFVKPHTVSKYDIHGFLIVPEDDEEEEK 591

  Fly   890 RI----KLDYEEIVPCDKQLIE---RWEQIIERN-STQIGNKKDPKVLGHAIRTGVPRSKRGDVW 946
            .:    .||.:.:...:.|.|.   :|:...... :.::....:.|.|   :|.|:|...|..:|
 Frog   592 LVAKVRALDLKTLSLTENQEISNVVKWDNYFASTVNREMACSPELKAL---VRNGIPHEHRSRMW 653

  Fly   947 TFLAEQHSMNTAPVDTKRFPNFNTP--YHMLLKHLTEHQH----AIFIDLGRTFPNHQFYKDPLG 1005
            .:....|        .|:..:...|  :..||::..|.|:    .|.:||.||.||::.|..|..
 Frog   654 KWFTNLH--------IKKLKDEAAPGYFQSLLQNALEKQNPASKQIELDLMRTLPNNKHYTSPTS 710

  Fly  1006 LGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKK 1070
            .|...|.|:|.|||..:|::|||||:..:..:.||:.|:.::|..|..::.....|..|...:..
 Frog   711 EGIQKLRNVLLAYSWRNPDIGYCQGINRLAAIALLYLDQEDAFWCLVTIVEAFMPRDYYTKTLLG 775

  Fly  1071 FQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDV 1135
            .|:.......|:.:.||.|....:|..|..||....|.|.||........:.|::|.|..|.|.|
 Frog   776 SQVDQRVFKDLMNEKLPRLCAHFEQYKVDYTLITFNWFLVVFVDSVVSDILFRIWDSLLYEGSKV 840

  Fly  1136 IFKFAIALLSVHKQQLLAKDNFEEIMDYLK 1165
            ||:||:.|....::::|...:...|..||:
 Frog   841 IFRFALGLFKYKEEEILKLQDSMSIFKYLR 870

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	48/240 (20%)
		DUF3350	831..880	CDD:463365	16/127 (13%)
		TBC	933..1152	CDD:214540	65/224 (29%)
		COG4372	<1190..>1353	CDD:443500
tbc1d2b	XP_012822167.2	PH_TBC1D2A	34..134	CDD:269966	18/69 (26%)
		Smc	322..>560	CDD:440809	44/306 (14%)
		TBC	640..857	CDD:214540	65/224 (29%)