DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and tbc1d1

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	XP_031751223.1	Gene:	tbc1d1 / 733547	XenbaseID:	XB-GENE-5959648	Length:	1286	Species:	Xenopus tropicalis

Alignment Length:	1403	Identity:	410/1403 - (29%)
Similarity:	632/1403 - (45%)	Gaps:	378/1403 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 LTASTSYGSLSSSAACAYQL-QLQQSAEASAEQPQNFMEFQGPITGLVYLLK-DPK-----DPLL 181
            |..|.:..||::.....:.: ::::....:.:..||.::.:..::....|.: ||.     |||:
Frog    25 LIGSLTVNSLTTMPMLPWVVAEIKKRNSKTVKNLQNALQIRLYVSSTSILCEPDPGKCQQWDPLI 89

  Fly   182 HIYLFECEAVEEMAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATNLK 246
            ...:|:|:. :.:.:|:|..:||::.         ..|:.....:...|...|  .|:  |..||
Frog    90 CSSIFDCKP-QLVQKLIHNSQDPSYF---------ACLLREENLASQESTCYL--FHS--ADPLK 140

  Fly   247 MSEAMRNAQHDTSPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTHFFE 311
            :.|.:.:.:|       :.|: |.:...|                     |.|.|:..:.:..||
Frog   141 VPEIIGSIRH-------AGKL-ARQEEVH---------------------SQLCDLDDSFSKKFE 176

  Fly   312 VMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDL 376
            |::.|::.|:.|:.|...||:.:.||.
Frog   177 VLFCGRVIVANKKAPPALIDECIDKFN-------------------------------------- 203

  Fly   377 KEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIEL 441
                                      .:..|..:||.:|.|..|     ||..:|  ...:.|..
Frog   204 --------------------------HVSCTKKKEGDSPTPQGD-----SPPPQP--DSGTGISF 235

  Fly   442 GHKEHS---------DGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASA---GPSQLHP 494
            |.|..|         |.::|             :.|..:.|   |:.|.|:..:.   |.|.|..
Frog   236 GDKLRSVFQSAFHDDDKNKP-------------IRKSYSQP---GLRTNTSFTNEWKDGRSSLPT 284

  Fly   495 NYAMDNIP--KQRDRSASQGCIPPY-VEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDVASCV 556
            ::...:|.  .||.....|..:.|. :|:|:||:|.:|:.::.|:|||.|::::.|.||:::.|.
Frog   285 SFEESDISLHVQRLCGEEQDSVQPTDMEENQTMLFTIGQAEVYLVSPDTKRIVIEKSFKEISFCS 349

  Fly   557 HGQKSLDHFGIICRE-LNNDG--YIGYVFKCQSEHVCDDIVAAIAQAFDTCA-EQKKKQDTQIFS 617
            .|.:..||||.|||| |.|.|  ::.|||:|.:..:.|:|:..:.|||...| :|..|...|:
Frog   350 QGIQHADHFGFICREPLLNGGCHFVCYVFQCANGALVDEIMLTLKQAFSVAAVQQNSKTLPQL-- 412

  Fly   618 CEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLM 682
            |:.|||...||||..:|||...|.:..:.:.|.|||:.||..::.:.   :|.. |.:||.:..:
Frog   413 CDTCPMQCMHKLCERIEGLPPTKIKLELQKHITTLSNQEQASMFEEI---QKIR-PRSEQQENEL 473

  Fly   683 MLLRAHC--ESRQQRHVH--DTAENRSEFLNQYLGG----------STIFMKAKRSLTNSFDNLL 733
            ::.|..|  |.:|:.|:|  :|.:| |:.......|          .::..|||||||.|.:|:|
Frog   474 VISRLRCLYEEKQRDHIHNAETKQN-SQAAESTANGLQTSASRFKLESLTSKAKRSLTESLENIL 537

  Fly   734 KR----------KPSKDD-------------------------IAVP--SH-NLRDIREGSAEPL 760
            .|          ..|.||                         :|:|  :| :|.|:.: |::..
Frog   538 SRGSRSRSLQESSASGDDDSSLCTPLDPSIKELSLCETEPAAPLAIPLKTHGSLGDLSK-SSDSY 601

  Fly   761 GTQSPPE----GFRSRSNTVGASP----------------------------------------- 780
            ..:.|.|    |||.|:||:...|
Frog   602 SCEHPEELVQQGFRRRANTLSHFPVTAQEFPEPVQITPSVSQRKLIRHHSVSTETPHKRNTPLPE 666

  Fly   781 -------SSKPTAEQ----LKSPMMDIFIKVG--------------------------------- 801
                   |::|||.:    ..||:....:|||
Frog   667 PDHNPVQSAEPTAPRPVSATSSPVTGKKLKVGSVGEAGAPLSQKSLFYRSTALRKKLHSSSSVPN 731

  Fly   802 ----------------NSPKE----------------AETHQGSWRQAILNSVVTPSKGLDS--- 831
                            ||.|.                ..|.:.||||.|...|.||.||.||
Frog   732 FLKFLAPVAENSTAGFNSSKSDFECKSIHSEAGCESPVRTRRHSWRQQIFLRVATPQKGCDSPNR 796

  Fly   832 ------------EVPTEFLS---PMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQA 881
                        ..|.|.:|   |:|.......|...||||||:.||.|.|:|.|||.||..|||
Frog   797 YDDHSDLGDIAPRSPLEPVSEDGPVRSAVAVRHRTTEELRELWKKAILQQILLLRMEKENQKLQA 861

  Fly   882 RQNENELKRIKLDYEEIVPCDKQLIERWEQIIER-NSTQIGNKKDPKVLGHAIRTGVPRSKRGDV 945
            .:|:.:.||:|||||||.||.|.:...||:::.. ..::|  |.|.:.:..|:..||||..||::
Frog   862 SENDLQNKRLKLDYEEITPCLKDVTLVWEKMLSTPGRSKI--KTDTEKIHAAVGQGVPRQHRGEI 924

  Fly   946 WTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLS 1010
            |.||:||:.:....:...:..  :|||..|||.||..||||.||||||||.|.::...||.||||
Frog   925 WKFLSEQYQLRHQHISKNQLK--DTPYKELLKQLTTQQHAILIDLGRTFPTHPYFSAQLGAGQLS 987

  Fly  1011 LFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQL 1075
            |:|:|||||:||||:||||||.|:.||||||..|.::|::||.||:...:|.:|.|||...|:|:
Frog   988 LYNILKAYSLLDPEVGYCQGLSFVAGVLLLHMTEEDAFKMLKFLMYDLGLRKQYRPDMITLQIQM 1052

  Fly  1076 YQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFA 1140
            ||||||:.|:..|||..|:..::.|:||||||.||:|:|||||||||||||::||:.|:||||.|
Frog  1053 YQLSRLLHDYHRDLYNHLETYEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGSEVIFKVA 1117

  Fly  1141 IALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEE 1205
            ::||..||..:|..:|.|.|::::|..:|.:....||:.:..||.|||.|||..|:|||:|||:|
Frog  1118 LSLLGSHKPLILQHENLESIVEFIKNTLPNLGLVQMEKTINQVFEMDISKQLQAYEVEYHVLQDE 1182

  Fly  1206 ITTTN--------HHLEMLNRE-KTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSL 1261
            :..::        :.||..|.. :.||..|.::||.:...|..||:|..:.|:....|:..|.:|
Frog  1183 LIDSSPLSDNQRINKLEKANSTLRKQNFDLLEELQVSHGRIQVLESTVENLQSNEVKLKRSVLTL 1247

  Fly  1262 ELTIQTLGRYVGQLVEHNPDLE---------LPNEVRR 1290
            ||....|...:.:|.....|::         .||::.:
Frog  1248 ELERSALLNTIEELRAQIKDMQGNKLCNDQNEPNQLNK 1285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	74/317 (23%)
		DUF3350	835..880	CDD:288663	21/47 (45%)
		TBC	933..1152	CDD:214540	121/218 (56%)
		RILP-like	<1176..1267	CDD:304877	36/99 (36%)
tbc1d1	XP_031751223.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2080
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	566	1.000	Inparanoid score	I1062
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164786at33208
OrthoFinder	1	1.000	-	-		FOG0003414
OrthoInspector	1	1.000	-	-		otm47633
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.070