Protein Alignment plx and Tbc1d9

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001104774.1
• Gene: Tbc1d9 / 71310
• MGIID: 1918560
• Length: 1264
• Species: Mus musculus
• Alignment Length: 1197
• Identity: 239/1197 - (19%)
• Similarity: 392/1197 - (32%)
• Gaps: 433/1197 - (36%)

  Fly   526 FLVGRCDLRLI-------SPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFK 583
            ||:|| :.:|:       ..::...||..|...|::     :|.:||..:...:|.      .||
Mouse   191 FLMGR-EAKLVIRWVDITQLEKNATLLLPDMIKVST-----RSSEHFFSVFLNINE------TFK 243

  Fly   584 CQSEHVCDDIVAAIA-------QAFD---TCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSE 638
            ...:      :|.||       :.|:   :..:.|||...::.:.         |...|....||
Mouse   244 LMEQ------LANIAMRQLLDNEGFEQDRSLPKLKKKSPKKVSAL---------KRDLDARAKSE 293

  Fly   639 KKTQALILRRIETLSDDEQEIVWAKF----------------CGSEKTN---------------- 671
            :......|.:.|.|.......:|..|                |.:.|..
Mouse   294 RYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVE 358

  Fly   672 ---------SPVAEQNQFLMMLLRAHCESRQQRHVHDTAENR-SEFLNQYLGGSTIFM-KAKRSL 725
                     ||::...:..|..|.|:.:.|      |....| |:||.|..  |.|:. |.....
Mouse   359 KADSCSVLPSPLSISTRNRMTFLFANLKDR------DFLVQRISDFLQQTT--SRIYSDKEFSGS 415

  Fly   726 TNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEG---FRSRSNTVGASPSSKPTAE 787
            .||.|:.:..:||....:.|..:             |.|..:|   |....|:|       |||.
Mouse   416 CNSSDDEVYSRPSSLVSSSPQRS-------------TSSDADGERPFNLNGNSV-------PTAT 460

  Fly   788 QLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDA 852
            |   .:|.::.:  .||:|                      .:.::..|||.
Mouse   461 Q---TLMTMYRR--RSPEE----------------------FNPKLAKEFLK------------- 485

  Fly   853 AELRELWR---TAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIE 914
               .:.|:   ....|.|.:.|.|        :..|..||
Mouse   486 ---EQAWKIHFAEYGQGICMYRTE--------KTRELVLK------------------------- 514

  Fly   915 RNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLL-KH 978
                                 |:|.|.||::|..|:  .::|    :....|.:   |..|: |.
Mouse   515 ---------------------GIPESMRGELWLLLS--GAIN----EKATHPGY---YEGLVEKS 549

  Fly   979 LTEHQHA---IFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLL 1040
            :.::..|   |..||.|:.|.|..:::.:|:.  :|..:|.||:..:|.:||||.:..:..||||
Mouse   550 MGKYNLATEEIERDLHRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAMNIVTSVLLL 612

  Fly  1041 HCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLV-------------KDHLPDLYVW 1092
            :..|..:|.||..|..|      .|||        |..:|:|             :|::|.||..
Mouse   613 YAKEEEAFWLLVALCER------MLPD--------YYNTRVVGALVDQGVFEELARDYVPQLYDC 663

  Fly  1093 LDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL-AKDN 1156
            :....|..|: :..|.||:|.|..|......|.|..|.|...|||:.|:|:|..:..:|| .||:
Mouse   664 MQDLGVISTI-SLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDD 727

  Fly  1157 FEEIM---DYLKTV------VPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHH 1212
            .|.:.   .||.:|      :|.:.|      :..:.|.|:|...|   |:...|   |.|:...
Mouse   728 GEAMTVLGRYLDSVTNKDSTLPPIPH------LHSLLSDDVGPYPA---VDIFRL---IGTSYEK 780

  Fly  1213 LEMLNREKTQNQHLEQQLQFAQSSIAQLE--TTRSSQQAQITTLQSQVQSLE----------LTI 1265
            ...:..:..:....:|:|:..|:    ||  |.|:..:..:|.....:..||          ||.
Mouse   781 FGTIRADLIEQMRFKQRLKVIQT----LEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLTS 841

  Fly  1266 QTLGRYVGQLVEHNPDLELPNEVR---------------------------RMLQQLDDLDRQRR 1303
            ...|.....|..|:|.|....:.|                           |:.|.||:......
Mouse   842 CYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFVLLFPWACGTHSDVLASRLFQLLDENGDSLI 906

  Fly  1304 KPIFTERKIGKSVSVNSHLGFPLKVL-------EELTERDELGSPQKQKKEKTPFFEQL------ 1355
            .  |.|...|.|.:.:..|...||:|       |...::||   |....:....|||.:
Mouse   907 N--FREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSCDQDE---PDSAFEATQYFFEDITPECTH 966

  Fly  1356 ------RQQQ-----------QQHRLNGGGQSSNVGE-------------SGSPTPPSRP----- 1385
                  |.:|           :|.|    |:.:|..|             |.|.|....|
Mouse   967 VVGLDSRGKQSADDGFVTVSLKQDR----GKRANSQENRNYLKLWTAENKSKSKTAKDLPKLNQG 1027

  Fly  1386 -------------------NRLLDNASARTVMQVKLDELKLPEHVDKFVANIKSPLEVDSGVGTP 1431
                               ..|....:|.|.:.:::.|      |.||.  |..|.:.|:..|.|
Mouse  1028 QFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGE------VGKFF--ITQPAKEDAVPGPP 1084

  Fly  1432 LSPPSTASNSSGGSIFSRMG------YRTTPPALSPLA---QRQSYGVAITTAPCPQHMEEVAP- 1486
                  ...:..|.:|.:.|      ..:|.|..:.||   :..|.|..:...    .:|:.:|
Mouse  1085 ------CGQAIPGMLFPKKGSSQSYVVESTEPLTASLAVDSEEHSLGGQMEDI----KLEDSSPR 1139

  Fly  1487 ---ATTMAVMPQEDVEEPQPMHPLSMV 1510
               |.:..::..:|.::...|...|::
Mouse  1140 DNGACSSMLISDDDTKDDSSMSSYSVL 1166

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	18/88 (20%)
		DUF3350	831..880	CDD:463365	8/51 (16%)
		TBC	933..1152	CDD:214540	67/235 (29%)
		COG4372	<1190..>1353	CDD:443500	40/208 (19%)
Tbc1d9	NP_001104774.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	18/81 (22%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	15/100 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	410..456		12/58 (21%)
		TBC	512..722	CDD:214540	69/281 (25%)
		EFh	<893..923	CDD:415501	8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1119..1162		7/46 (15%)