Protein Alignment plx and Tbc1d2b

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_919315.2
• Gene: Tbc1d2b / 67016
• MGIID: 1914266
• Length: 965
• Species: Mus musculus
• Alignment Length: 1200
• Identity: 241/1200 - (20%)
• Similarity: 409/1200 - (34%)
• Gaps: 439/1200 - (36%)

  Fly   131 GSLSSSAAC-AYQLQLQQSAEASAEQPQNFMEFQGPITGLVYLLKDPKDPLLHIYLFECEAVE-E 193
            |.|..:.|| :||.: .::||..|:.|.:   ||....|.|.:||.|...|:..:|.|.:... |
Mouse    80 GHLDIADACFSYQGR-DEAAEPGADPPTH---FQVHSAGAVTVLKAPNRELMTYWLQELQQKRWE 140

  Fly   194 MAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATNLKMSEAMRNAQHDT 258
            ....:..|:..:.| ..:.|..|:                  |:.|...|::       .:||
Mouse   141 YCNSLDMMKWDSRT-SPTPGDFPK------------------GLVARDTTDI-------ISQH-- 177

  Fly   259 SPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLADIS--------PNHTHFFEVMYV 315
             |||.:.|.:.    ...:.::.|              .|:.|.:        ||..:|:.:...
Mouse   178 -PNPSAEKART----VLAVEAAPG--------------ELVGDRAAHQPAPGHPNPINFYSLKQW 223

  Fly   316 GKIRVSQKRVPNTFIDDALPKFKA----YDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDL 376
            |           ..:.:::..|:.    .:::|.....|.:..|       ::..|.      ||
Mouse   224 G-----------NELKNSMSSFRPGRGHSESRRTVFYTNEEWEL-------LDPPPK------DL 264

  Fly   377 KEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPR--PLEDNKENKSPEKRPLLRGQSQI 439
            :|....|:.:            ||:.:     ..:|.|..  |.|..: |....||||    ..|
Mouse   265 EESLVPEERK------------KPMPE-----GSKGVASSGFPFEFGR-NPYKGKRPL----KDI 307

  Fly   440 ELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTAS-ASAGPSQLHPNYAMDNIPK 503
            ...:|.....|.||     ||                  ||.|:| :|.||::..|...: .|..
Mouse   308 IGSYKNRHSSSDPL-----LE------------------GTATSSGSSGGPTKPVPEMQL-QIQS 348

  Fly   504 QRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGII 568
            |::.          :||.:                           ||::|    ||.|  ..::
Mouse   349 QQEE----------LEQLK---------------------------KDLSS----QKEL--IRLL 370

  Fly   569 CRELNNDGYIGYVFKCQ-SEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTD 632
            .:.:.:..|..|....| |:.|..|.:..:.|           :|.||..           |...
Mouse   371 QQTVRSSQYDKYFTNPQISQGVPGDTLELLHQ-----------KDEQILG-----------LSGQ 413

  Fly   633 VE--GLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQR 695
            :|  ||.::..|    :.:.||                  .|.|.|.|:.|.||:
Mouse   414 LERFGLEKESLQ----QEVRTL------------------KSKVGELNERLGMLM---------- 446

  Fly   696 HVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPL 760
               :|.:.:.|.                        ::|....:..::.|:             |
Mouse   447 ---ETIQAKDEV------------------------IIKLSACEGSVSSPT-------------L 471

  Fly   761 GTQSPPEGFRSRSNTVGASPSSKPTAE--QLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVV 823
            |..||.           |.|:||...|  :||..:                 ||...|
Mouse   472 GPSSPL-----------AIPASKDQLELDRLKDSL-----------------QGYKSQ------- 501

  Fly   824 TPSKGLDSEVPTEFLSPMRKPAKRGKRD-----AAELRELWRTAIRQTIMLNRMET--------- 874
              :|.|:.|:..  ||.:|:.|:|.:||     ::...:|.:...:..|:|..|:|
Mouse   502 --NKFLNKEILE--LSALRRNAERRERDLMAKYSSLEAKLCQVESKYLILLQEMKTPVCSEEQGP 562

  Fly   875 ---------ENAMLQARQNENELKRIK------------------------------LDYEEIVP 900
                     |:|:....|.:.|...:|                              ||.:.:..
Mouse   563 ARDVIAQLLEDALQVESQEQPEQAFVKPHLVSEFDIYGFRTVPDDDEEEKLVAKVRALDLKTLYL 627

  Fly   901 CDKQLIE---RWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDT 962
            .|.|.:.   :||....  ||..........|.:.||.|:|...|..||.:..::|        |
Mouse   628 TDNQEVSTGVKWENYFA--STMNREMACSPELKNLIRAGIPHEHRSKVWKWCVDRH--------T 682

  Fly   963 KRFPNFNTP--YHMLLKHLTEHQH----AIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSIL 1021
            ::|.:...|  :..||:...|.|:    .|.:||.||.||::.|..|...|...|.::|.|:|..
Mouse   683 RKFKDSMEPDYFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSSPTSEGIQKLRSVLLAFSWR 747

  Fly  1022 DPELGYCQGLGFICGVLLLHCDEANSFQLL---KHLMFRRNMRTKYL----PDMKKFQLQLYQLS 1079
            :|::||||||..:..|.||:.|:.::|..|   ..:...|:..||.|    .|.:.|:
Mouse   748 NPDIGYCQGLNRLVAVALLYLDQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFR------- 805

  Fly  1080 RLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALL 1144
            .|:.:.||.|:...:|..|..||....|.|.||........:.:::|....|...|||:||:||.
Mouse   806 DLLSEKLPRLHTHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALF 870

  Fly  1145 SVHKQQLLAKDNFEEIMDYL----KTVVPKMEHTCMEQIMKLVFSMDIG-------KQLAEYKVE 1198
            ...::::|...:...|..||    :|::         ...||: |:..|       :|:...:.
Mouse   871 KYKEEEILKLQDSMSIFKYLRYFTRTIL---------DARKLI-SISFGDLNPFPLRQIRNRRA- 924

  Fly  1199 YNVLQEEITTTNHHLEMLNREKTQNQHLEQ 1228
                        :|||.:..|.|:.:.:.:
Mouse   925 ------------YHLEKVRLELTELEAIRE 942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	57/315 (18%)
		DUF3350	831..880	CDD:463365	15/71 (21%)
		TBC	933..1152	CDD:214540	69/231 (30%)
		COG4372	<1190..>1353	CDD:443500	6/38 (16%)
Tbc1d2b	NP_919315.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..27
		PH_TBC1D2A	36..144	CDD:269966	21/67 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..288		9/53 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	310..340		13/52 (25%)
		CwlO1	345..>586	CDD:443091	71/416 (17%)
		RabGAP-TBC	709..878	CDD:459855	54/175 (31%)