DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment plx and Tbc1d1

DIOPT Version :10

Sequence 1:NP_001163511.1 Gene:plx / 40704 FlyBaseID:FBgn0261261 Length:1572 Species:Drosophila melanogaster
Sequence 2:NP_001297540.1 Gene:Tbc1d1 / 57915 MGIID:1889508 Length:1255 Species:Mus musculus


Alignment Length:1361 Identity:405/1361 - (29%)
Similarity:577/1361 - (42%) Gaps:435/1361 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   176 PKDPLLHIYLFECEAVEEMAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHAT 240
            |.|||:...:|||:. :.:.:|:|...||::.                                 
Mouse    84 PWDPLICSSIFECKP-QRVHKLIHNSHDPSYF--------------------------------- 114

  Fly   241 PATNLKMSEAMR-------NAQHDTS-PNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLS 297
             |..:|...|.|       .|...|. |..:||..:|.|                  .:.|..|.
Mouse   115 -ACLIKEDAAHRQSLCYVFKADDQTKVPEIISSIRQAGK------------------IARQEELR 160

  Fly   298 LLADISPNHTHFFEVMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVG 362
            ..::........|||::.|::.|:.|:.|...||:.:.||                         
Mouse   161 CPSEFDDTFAKKFEVLFCGRVTVAHKKAPPALIDECIEKF------------------------- 200

  Fly   363 IEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKENKSP 427
                                   .|.......|.:|.       ||......|||:  .|....|
Mouse   201 -----------------------NHVSCGRRTDWEAP-------TGQPSAPGPRPM--RKSFSQP 233

  Fly   428 EKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNK--------QPTPPRDQGVGTGTAS 484
            ..|.|        ...||..|.|  |.:::.....|.|.|.        |||.            
Mouse   234 GLRSL--------AFRKEFQDAS--LRSSTFSSFDNDIENHLIGGHNVVQPTD------------ 276

  Fly   485 ASAGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDF 549
                                             :|:||||:|.:|:.::.|||||.|::.|.|:|
Mouse   277 ---------------------------------MEENRTMLFTIGQSEVYLISPDTKKIALEKNF 308

  Fly   550 KDVASCVHGQKSLDHFGIICRELNNDG-----YIGYVFKCQSEHVCDDIVAAIAQAFDTCA-EQK 608
            |:::.|..|.:.:||||.||||.:..|     ::.|||:|.:|.:.|:|:..:.|||...| :|.
Mouse   309 KEISFCSQGIRHVDHFGFICRECSGGGSGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQT 373

  Fly   609 KKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSP 673
            .|...|:  ||.||:...||||..:||::..||:..:.:.:.||::.||..::.:.......|. 
Mouse   374 AKAPAQL--CEGCPLQGLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNE- 435

  Fly   674 VAEQNQFLMMLLRAHCESRQQRHVH-----DTAENRSEFLNQYLGGS-------TIFMKAKRSLT 726
             ..:|:.::..||...|.:|:.|.|     .|.:..:|.:...|..|       ::..:||||||
Mouse   436 -QRENELIISFLRCLYEEKQKEHSHTGEPKQTLQVAAENIGSDLPPSASRFRLDSLKNRAKRSLT 499

  Fly   727 NSFDNLLKR-------------------------KPSK-----DDIAVP-----------SHNLR 750
            .|.:::|.|                         ..||     |..|.|           |.:|.
Mouse   500 ESLESILSRGNKARGLQDHSASVDLDSSTSSTLSNTSKELSMGDKEAFPVSETSFKLLGSSDDLS 564

  Fly   751 DIREGS-AEPLGTQSPPEGFRSRSNTVGASP----------SSKPTAEQLK-------------- 790
            ...||. ||.....||.:.||.|:||:...|          .|.|...|.|              
Mouse   565 SDSEGHIAEESALLSPQQAFRRRANTLSHFPVECPAPPEPAQSSPGVSQRKLMRYHSVSTETPHE 629

  Fly   791 -------------------------------SPMMDIFIKVGNS--------PKE---------- 806
                                           ||....::|..:|        ||.          
Mouse   630 RNVDHLPGGESQGCPGQPSAPPPPRLNPSASSPNFFKYLKHNSSGEQSGNAVPKSVSYRNALRKK 694

  Fly   807 ----------------------------------------------AETHQGSWRQAILNSVVTP 825
                                                          .:|.:.||||.|...|.||
Mouse   695 LHSSSSVPNFLKFLAPVDENNTCDFKNTNRDFESKANHLGDTDGTPVKTRRHSWRQQIFLRVATP 759

  Fly   826 SKGLDS-----------EVPTEFLSPMRK--------PAKRGKRDAA-ELRELWRTAIRQTIMLN 870
            .|..||           |:|..  ||:..        |.:..||..: ||||||:.||.|.|:|.
Mouse   760 QKACDSPSRYEDYSELGELPPR--SPLEPVCEDGPFGPVQEEKRKTSRELRELWKKAILQQILLL 822

  Fly   871 RMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKK---DPKVLGHA 932
            |||.||..|||.:|:...||:|||||||.||.|::...||:::   ||. |..|   |.:.:..|
Mouse   823 RMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKML---STP-GRSKIKFDMEKVHSA 883

  Fly   933 IRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNH 997
            :..||||..||::|.|||||..:. .|..:|:.|. :.||..|||.||..||||.||||||||.|
Mouse   884 VGQGVPRHHRGEIWKFLAEQFHLK-HPFPSKQQPK-DVPYKELLKKLTSQQHAILIDLGRTFPTH 946

  Fly   998 QFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRT 1062
            .::...||.|||||:|:|||||:||.|:||||||.|:.|:||||..|..:|::||.|||...:|.
Mouse   947 PYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRK 1011

  Fly  1063 KYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDL 1127
            :|.|||...|:|:||||||:.|:..|||..|:::::.|:||||||.||||:|||||||||||||:
Mouse  1012 QYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTVFASQFPLGFVARVFDM 1076

  Fly  1128 LFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQL 1192
            :||:.|:||||.|::||..||..:|..:|.|.|:|::|..:|.:....||:.:..||.|||.|||
Mouse  1077 IFLQGSEVIFKVALSLLGSHKPLILQHENLETIVDFIKNTLPNLGLVQMEKTISQVFEMDIAKQL 1141

  Fly  1193 AEYKVEYNVLQEEI-----TTTNHHLEMLNREKT------QNQHLEQQLQFAQSSIAQLETTRSS 1246
            ..|:|||:|||||:     .:.|..:|.|  |||      ||..|.:|||.|.:.|..||.|   
Mouse  1142 QAYEVEYHVLQEELIESSPLSDNQRMEKL--EKTNSSLRKQNLDLLEQLQVANARIQSLEAT--- 1201

  Fly  1247 QQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRR--MLQQLDDLDRQRRKP 1305
             ..::.|.:|:::...||:                     ||.|  :||.:::|.||..:|
Mouse  1202 -VEKLLTSESKLKQAALTL---------------------EVERSALLQMVEELRRQSARP 1240

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plxNP_001163511.1 PTB_TBC1D1_like 301..601 CDD:269967 70/312 (22%)
DUF3350 831..880 CDD:463365 24/68 (35%)
TBC 933..1152 CDD:214540 124/218 (57%)
COG4372 <1190..>1353 CDD:443500 42/129 (33%)
Tbc1d1NP_001297540.1 PTB 21..150 CDD:269911 20/100 (20%)
PTB_TBC1D1_like 164..365 CDD:269967 70/312 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 208..228 7/28 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 509..544 2/34 (6%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 559..581 7/21 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 595..614 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 621..681 4/59 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 764..786 6/23 (26%)
DUF3350 777..832 CDD:463365 23/56 (41%)
TBC 884..1101 CDD:214540 124/218 (57%)
PRK12704 1139..>1239 CDD:237177 41/126 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1233..1255 4/8 (50%)

Return to query results.
Submit another query.