DRSC/TRiP Functional Genomics Resources

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Protein Alignment plx and tbc1d1

DIOPT Version :9

Sequence 1:NP_001163511.1 Gene:plx / 40704 FlyBaseID:FBgn0261261 Length:1572 Species:Drosophila melanogaster
Sequence 2:XP_005168426.1 Gene:tbc1d1 / 561193 ZFINID:ZDB-GENE-060710-1 Length:1276 Species:Danio rerio


Alignment Length:1481 Identity:416/1481 - (28%)
Similarity:628/1481 - (42%) Gaps:463/1481 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 TFRGSASVDPRYSASMLPWTINDIRSTESYTKLSVGIENGILE-SYNSDFELQFSHPLKHIVGMC 72
            |..||.::.|:.:.::|||.:.:||            ..|:.| :.|.:|...:|..::      
Zfish    48 TLVGSLAIHPQTTMAILPWVVAEIR------------RPGVREKNRNLEFNGNYSPEIR------ 94

  Fly    73 RIIHKPQAKSIGNGFLQLKSSAGQTSSSSAVASSMGGAASSSLTGNGLRHTLTASTSYGSLSSSA 137
               .:|....|                                                  |:|:
Zfish    95 ---DQPVVLQI--------------------------------------------------SASS 106

  Fly   138 ACAYQLQLQQSAEASAEQPQNFMEFQGPITGLVYLLKDPKDPLLHIYLFECEAVEEMAELMHQMR 202
            .|.                  .::..||        ..|.:||.|:.||: .....:.:|:|..:
Zfish   107 VCC------------------ILDTAGP--------GKPWNPLQHMVLFD-HRPHHVTKLIHNSQ 144

  Fly   203 DPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPA-------TNLKMSEAMRNAQHDTSP 260
            :|::.                        |.|.......|       ..||:            |
Zfish   145 EPSYF------------------------GCLLREEKKAACYVFRCQDQLKV------------P 173

  Fly   261 NPVSSKMKASKSYTHGLSSSSGTVNIPTS--TSAQSNLSLLADISPNHTHFFEVMYVGKIRVSQK 323
            ..:|:..:|.||    .:....|.::|::  :.|.|:.:..||.:......|||::.|::.|:.|
Zfish   174 EIISTLRQAGKS----SARQEDTPSLPSNGQSDASSSTATAADAATAFAKKFEVLFCGRVVVAHK 234

  Fly   324 RVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLKEEDEEEQEQHK 388
            :.|...||:.:.||                     |.|.:....::.::                
Zfish   235 KAPPALIDECIEKF---------------------GRVSVTGSLAAGIR---------------- 262

  Fly   389 GHDDSQDSQAKPLVQLQLTGAEE--GAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQ 451
                    :|..|.|: :.|..|  |...|||...::...|..:.|             ..:|..
Zfish   263 --------RAFSLNQV-VNGTNEGDGGGKRPLFFKRDQSFPFLQAL-------------DENGLS 305

  Fly   452 PLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIPKQRDRSASQGCIPP 516
            |     :|:                                           :|....:.|..|.
Zfish   306 P-----ELQ-------------------------------------------RRAADGATGVQPT 322

  Fly   517 YVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDG---YI 578
            .:::||||:|.:||..:.|:|||.|:|.:.|.|::::.|..|.:.:||||.||||....|   ::
Zfish   323 SLQENRTMLFTIGRSQIFLVSPDTKKVAIEKSFREISFCSQGIRHVDHFGFICRESVECGGCQFV 387

  Fly   579 GYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQA 643
            .|||:|.:|.:.|:|:..:.|||...|.|:..: ||...|:.||:...||||..:|||...|.:.
Zfish   388 CYVFQCANEALVDEIMLTLKQAFSVAALQQNSR-TQSQQCDGCPLQQLHKLCDRIEGLHPSKAKL 451

  Fly   644 LILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFL 708
            .:.:.:..|.:.||..|:.....:...:.  .|:|:.:...||...|.||:.|.|:....:...:
Zfish   452 ELQKHLADLDNQEQAAVFESTMKARPKSD--QEENELIFSCLRRMYEDRQKTHTHNGQTKKDVVV 514

  Fly   709 N--QYLGGSTIFM-----KAKRSLTNSFDNLLK--------RKPSKDD----------------- 741
            |  ..:..|.:.:     :||||||.|.:.:.|        |:.|:.:                 
Zfish   515 NAESSVSSSRVRLEEFKSRAKRSLTESLEGIWKGGNKSKSQRENSEGESNSSSSTTLSSTHQETS 579

  Fly   742 ---------IAVP--SHN-------LRDIREGSAEPLGTQSPPEGFRSRSNTVGASP---SSKPT 785
                     ::.|  |||       |.....|..:|   :|||:|||.|::|:..||   ||:|:
Zfish   580 LQEPLCSLLLSSPLRSHNSTGNLKHLEGSDRGQEDP---ESPPQGFRRRASTISHSPMLSSSEPS 641

  Fly   786 AEQLK--------------------------------SPM------------------------- 793
            ...|:                                ||:                         
Zfish   642 LPPLQPTAANKPKLVRHYSVSTDSPHQSNPSSSPASSSPVCQRPLRPRSFALDHSTRPLKRSPSG 706

  Fly   794 -------------MDIFIK-----------------------------VG-NSPKEAETHQGSWR 815
                         :..|:|                             :| :||.....|  |||
Zfish   707 LSGFRARLHSSSSVPNFLKFLAPVVESDDTCDSQRKSDVAALSSPGCVIGDDSPLRNRRH--SWR 769

  Fly   816 QAILNSVVTPSKGLDSEVPT-EFLSPM--------------RKPAKRGKRDAAELRELWRTAIRQ 865
            |.|...|.||.||.|::..| |..|.|              ..|.:|.||..||||:|||.||.|
Zfish   770 QQIFLRVATPQKGSDAKESTLEVGSRMALGGGVGGGDKTLGAVPEERRKRSGAELRKLWRKAILQ 834

  Fly   866 TIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKK---DPK 927
            .|:|.|||.||..|||.:::.:.||.|||||||.||.|.:...||:::    ...|..|   |..
Zfish   835 QILLLRMEKENQKLQASESDLQCKRQKLDYEEITPCLKDVTLVWERML----GTAGRAKVRFDMD 895

  Fly   928 VLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGR 992
            .:..|:..||||..||::|.||:||:.:. ..|.:.:.||.:|||..|||.||..||||.|||||
Zfish   896 EIHGAVGQGVPRQHRGEIWKFLSEQYLLR-QEVPSAKPPNNDTPYKELLKQLTSQQHAILIDLGR 959

  Fly   993 TFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFR 1057
            |||.|.::...||.|||||:|||||||:||||:||||||.|:.||||||..|.::|.:||.||:.
Zfish   960 TFPTHPYFSAQLGAGQLSLYNLLKAYSLLDPEVGYCQGLSFVAGVLLLHMSEEDAFHMLKFLMYD 1024

  Fly  1058 RNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVA 1122
            ..:|.:|.|||...|:|:||||||:.|:..:||..|:..::.|:||||||.||.|:|.|||||||
Zfish  1025 MGLRKQYRPDMIILQIQMYQLSRLLHDYHRELYSHLELYEIGPSLYAAPWFLTAFASHFPLGFVA 1089

  Fly  1123 RVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMD 1187
            ||||:|||:.|:||||.|::||..||..:|..||.|.|::::||.:|.:....||:.:..|..||
Zfish  1090 RVFDMLFLQGSEVIFKVALSLLGSHKPLILQHDNLEAIVEFIKTTLPNLGLVQMEKTINQVSEMD 1154

  Fly  1188 IGKQLAEYKVEYNVLQEEI----TTTNHHLEMLNREKT------QNQHLEQQLQFAQSSIAQLET 1242
            |.|||..|:|||:|||:|:    :|.:|.......|||      ||..|.::||.|.:.|..|||
Zfish  1155 ISKQLQAYEVEYHVLQDELLDGPSTLSHSQRAAQLEKTNGSLRQQNLDLLEELQVAHAKIRCLET 1219

  Fly  1243 ------TRSSQ-QAQITTLQSQVQSLELTIQTLGRYVGQLVEHN--PDLEL 1284
                  .|.:: |:|:.|||.:...|:.|:..|...:..|...|  |||::
Zfish  1220 RVDGLVNREAELQSQVKTLQQEQTDLQQTVCKLRDLLSSLGISNPCPDLQI 1270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plxNP_001163511.1 PTB_TBC1D1_like 301..601 CDD:269967 65/304 (21%)
DUF3350 835..880 CDD:288663 25/59 (42%)
TBC 933..1152 CDD:214540 124/218 (57%)
RILP-like <1176..1267 CDD:304877 40/107 (37%)
tbc1d1XP_005168426.1 PH-like 40..182 CDD:327399 37/267 (14%)
PTB_TBC1D1_like 217..410 CDD:269967 64/299 (21%)
DUF3350 <811..849 CDD:314662 21/37 (57%)
TBC 901..1119 CDD:214540 124/218 (57%)
SH3_and_anchor <1158..1254 CDD:275056 34/95 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 251 1.000 Domainoid score I2059
eggNOG 1 0.900 - - E1_KOG4436
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 560 1.000 Inparanoid score I1062
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D164786at33208
OrthoFinder 1 1.000 - - FOG0003414
OrthoInspector 1 1.000 - - otm25578
orthoMCL 1 0.900 - - OOG6_105859
Panther 1 1.100 - - LDO PTHR22957
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2765
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
1312.830

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