Protein Alignment plx and rabgap1

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_073770556.1
• Gene: rabgap1 / 559632
• ZFINID: ZDB-GENE-170622-1
• Length: 1076
• Species: Danio rerio
• Alignment Length: 1184
• Identity: 260/1184 - (21%)
• Similarity: 450/1184 - (38%)
• Gaps: 288/1184 - (24%)

  Fly   356 SSEGGVGIEAKPSSSLKSHD---LKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTG----AEEGA 413
            :|.|.:.:.:...|:|.|.|   :....:|....:.|.||.:            ||    :|||.
Zfish     5 ASVGKISVSSDSVSTLNSEDFVLVSRLGDETPSTNNGSDDEK------------TGLKVISEEGV 57

  Fly   414 APRPLEDNKENK-SPEKRPLLRGQSQIE-------LGHKEHS---------DGSQP--------- 452
            :.:.:.:..|.: ..|...:|...|..|       ||..:|.         .||.|
Zfish    58 SFKIVGNGSEQQLQQELEDVLMDPSVTELVVGPDHLGQGDHGYPTTAVPSRSGSVPPKLEIVLPI 122

  Fly   453 -------LAANSQLEAPNVIVNKQPTPPRDQGVGT-----GTASASAGPSQLHPNYAMDNIPKQR 505
                   |...|..:.|:.:....|.|..|..|.:     |.||.:|..|:
Zfish   123 QGAQESELNERSYRDEPSDLSPGTPVPDEDSVVFSKLTYLGCASVNAPRSE-------------- 173

  Fly   506 DRSASQGCIPPYVEQNRTMVFLVGRCDL----------------RLISPDRK-QVLLYKDFKDVA 553
                        ||..|.:..|..:|.:                ||:.|... ::..|..:| :.
Zfish   174 ------------VEALRMVSILRSQCQMPLDVTLSVPGVSEGTVRLLDPQSSTEIANYPIYK-IL 225

  Fly   554 SCVHGQKSL---DHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQI 615
            .||.|....   |.|.......|.:.:..:||:|:.:.....|:.:.|.||...|.:.
Zfish   226 FCVRGHDGTPESDCFAFTESHYNTEIFRIHVFRCEIQEAVSRILYSFATAFRRSANKA------- 283

  Fly   616 FSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQF 680
                        .|.|....|:...........:|...||           .:.|.|.|::....
Zfish   284 ------------PLATKAPPLTPDSDVFTFTVSLEIKEDD-----------GKGTFSAVSKDKDR 325

  Fly   681 LMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVP 745
            ....|||..:.:...:|..|: |:...:.:..|   :.:...:::.||..:||
Zfish   326 QSFKLRAGMDKKIVIYVQQTS-NKELAIERCFG---LLLSPGKNVKNSDMHLL------------ 374

  Fly   746 SHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETH 810
                      ..|.:|..|..:.:....:....:|..:...|:              :||:
Zfish   375 ----------DLESMGKSSDGKSYIITGSWNPNTPQFQAVNEE--------------TPKD---- 411

  Fly   811 QGSWRQAILNSVVTPSKGLDSEVPTEFLSPMR----KPAKR-----GKRDAAELRELWRTAIRQT 866
            :..:....::.|:|     :.|.|..||...|    .|.:|     .||...|...|   .:||
Zfish   412 KFMYMTTAVDLVIT-----EVEEPVRFLLETRVRVCSPNERLFWPFSKRSYTETFYL---KLRQ- 467

  Fly   867 IMLNRMETENA----MLQARQNENELKRIKL----------DYEEIVP----------------- 900
             |.|:....|:    .:.:.::|.|.:|.|.          .:...||
Zfish   468 -MENKERKSNSDTLYEVMSLESETERERRKTTASPGVLSSGSHGSTVPSPPEDDEEEDNDEPLLS 531

  Fly   901 --------CDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNT 957
                    |.::::|.|.:::.|....:..:  ||.|...:|:|||.:.||:||..||..|: |.
Zfish   532 GSGDVSKECAEKILETWGELLSRWHLNLAVR--PKQLPALVRSGVPEALRGEVWQLLAGCHN-ND 593

  Fly   958 APVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILD 1022
            ..|:         .|..|:...:....||..|:.||||.|.::||..|.||.||:.:.||||:.|
Zfish   594 HLVE---------EYRTLITKESPQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYD 649

  Fly  1023 PELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLP 1087
            .|:|||||..|:..|||||..|..:|.:|..:||...:|..:..:.:....:.:||.||:::.:|
Zfish   650 EEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFEYGLRELFKQNFEDLHCKFFQLERLMQECIP 714

  Fly  1088 DLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL 1152
            |||.......:...:||:.|.||:|:::|||..|..:.|||..|...|||..|::||...|..||
Zfish   715 DLYTHFLNLGLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALSLLKTSKDDLL 779

  Fly  1153 AKDNFEEIMDYLKTVVPK--MEHTCMEQIMKLVFSMDIG-KQLAEYKVEYNVLQEEITTTNHHLE 1214
            ..| ||..:.:.:..|||  ......:::|:|..||.|. |:|.:|:.||:.::|:.......:|
Zfish   780 QTD-FEGALKFFRVPVPKRYRSEENAKKLMELACSMKISQKKLKKYEKEYHTIREQQEQQEAPIE 843

  Fly  1215 MLNREKTQNQHLEQQLQFAQSSIA-QLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEH 1278
            ...||..:.|....:|:.....:| :|.:::.:.:..:...:.:..:|...:         |:..
Zfish   844 RYERENRRLQEANMRLEQENDDLAHELVSSKIALRKDLDNAEEKADALNKEL---------LITK 899

  Fly  1279 NPDLELPNEVRRMLQQLDDLDRQ-RRKPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQ 1342
            ...:|..:|.||:.::...|... ||:...:|.:|.|:.|:   :|...::..:|:||.|
Zfish   900 QKLVESEDEKRRLEEESAQLKEMCRRELDKSESEIKKNGSI---IGEYKQICSQLSERLE----- 956

  Fly  1343 KQKKEKTPFFEQLRQQQQQHRLNGGGQSSNV------------GESGSPTPPSRPNRLLDNASAR 1395
            ||:.......|::|.     ::.|..:.||:            .:.||..........|.|....
Zfish   957 KQQTSNRGELEKIRM-----KVEGCEKCSNLFSKEGRLKVLSAPKEGSEEDTDEEKEALKNQLRE 1016

  Fly  1396 TVMQVKLDELKLPE 1409
            ..:::...:|:|.|
Zfish  1017 MELELAQTKLQLVE 1030

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	59/309 (19%)
		DUF3350	831..880	CDD:463365	16/61 (26%)
		TBC	933..1152	CDD:214540	82/218 (38%)
		COG4372	<1190..>1353	CDD:443500	33/164 (20%)
rabgap1	XP_073770556.1	None