Protein Alignment plx and rabgap1l

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_073792904.1
• Gene: rabgap1l / 555272
• ZFINID: ZDB-GENE-050208-389
• Length: 1021
• Species: Danio rerio
• Alignment Length: 1146
• Identity: 248/1146 - (21%)
• Similarity: 443/1146 - (38%)
• Gaps: 288/1146 - (25%)

  Fly   396 SQAKPLVQLQLTGAE--EGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQ 458
            |:.:|.:::...|:|  |.|....|:|..:....|:.   :|.:||           :|.:.::.
Zfish    39 SEGRPRLKMSWNGSEQLERAMEEVLDDVADGAGAEQE---KGCTQI-----------RPPSLDTA 89

  Fly   459 LEAPNVIVNKQPTPPRDQGVG------TGTASASAGPSQLHPNYAMDNIPKQRDRSA-------- 509
            ....:..:.:.||.|.::.|.      .|.....|..|:.....||..:   |..||
Zfish    90 PHESSAALLESPTVPEEESVQFSKLSYLGCTWVKAPRSETEAQKAMATL---RAESAIPIPVILH 151

  Fly   510 ----SQGCIPPYVEQNRT---------MVFLVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKS 561
                |.||:....:.:.|         ::|....|:..:.|             |..|.....:|
Zfish   152 VPNGSDGCVRIVDQASGTEIASFPIYKVLFCARGCEGSVES-------------DCFSFTESYRS 203

  Fly   562 LDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWY 626
            .:.|.|            :||.|   |: .:.|:.|..:|.|..::..|..|::   :..|:
Zfish   204 SEDFQI------------HVFSC---HI-KEAVSRILYSFSTAFKRSAKAATEM---QDSPL--- 246

  Fly   627 HKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTN-SPVAEQNQFLMMLLRAHCE 690
             .|..|    |:..|.::.|   |...||            .|.| |||.:........||...:
Zfish   247 -PLSPD----SDVFTFSVSL---EVREDD------------GKGNFSPVPKDRDKYYFKLRQGVQ 291

  Fly   691 SRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREG 755
            .:....|...  |..|.:.:...|  :.:...:.:.||..:||       |:.....|    .:|
Zfish   292 KKVSVVVQQL--NNKELVIERCFG--MLLSPGQKVRNSDMHLL-------DMESMGKN----ADG 341

  Fly   756 SAEPL-GTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAIL 819
            .|..: |..:|        ||    |:.:|..|              ::||:.:.:.......::
Zfish   342 KAYVITGIWNP--------NT----PAFQPLNE--------------DTPKDKQVYMTVAVDLVV 380

  Fly   820 NSVVTPSKGLDSEV----PTE--------------FLSPMRKPAKRGKRDAAELRELWRTAIRQT 866
            ..||.|.:.|...:    |..              |...:::.:.:|.:|         ..:.:.
Zfish   381 TEVVEPVRFLMEALVRVYPANERFWYFSRKAFCETFYLKLKQGSVKGSQD---------DMMYEV 436

  Fly   867 IMLNRMETENAMLQAR-QNENELKRIKLDYEEIV---------PCDKQLIERWEQIIERNSTQIG 921
            :.|.:.....:..:.| |:..|.:..:.|.:..:         .|.::::|.|..|:.|....:.
Zfish   437 VSLEKHSECGSQARGRLQSPTEEEEPEEDSDSEISSGTGDVSKDCPEKILESWGGILNRWQGNLL 501

  Fly   922 NKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAI 986
            .:  ||.|...::.|:|.:.|.:||..|:..|: :.|.::         .|.:|:...:..:..|
Zfish   502 TR--PKGLSALVKPGIPEALRAEVWQLLSGCHN-DQALLE---------QYRILITKESAQEAVI 554

  Fly   987 FIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLL 1051
            ..|:.||||.|.::||..|.||.||:.:.||||:.|.|:|||||..|:..|||||..|..:|.:|
Zfish   555 TRDIHRTFPAHDYFKDSGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFCVL 619

  Fly  1052 KHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQF 1116
            ..:||...:|..|..:.:....:.|||.||:::.||||:....:.::...:||:.|.||:|:::|
Zfish   620 VKIMFNYGLRELYRNNFEDLHCKFYQLERLLQELLPDLWSHFQELNLEAHMYASQWFLTLFTAKF 684

  Fly  1117 PLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPK----------- 1170
            ||..|..:.|||..|..::||..|:|||...|:.||..| ||..:.:.:..:||
Zfish   685 PLCMVFHITDLLLCEGLNIIFNVALALLKTSKEDLLQAD-FEGALKFFRVQLPKRYRAAENARRL 748

  Fly  1171 MEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQS 1235
            ||..|..::..        |:|.:::.||..|:|........::...||..:.|....:|:....
Zfish   749 MEQACNIKVPT--------KKLKKFEKEYQSLRESQLQQEDPIDRYQRENRRLQEASMRLEQEND 805

  Fly  1236 SIA-QLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLD 1299
            .:| :|.|::       ..|::.:...|.....|.:            ||.|..:|:::..::..
Zfish   806 DLAHELVTSK-------IALRNDLDQAEDKADVLNK------------ELLNTKQRLVETEEEKR 851

  Fly  1300 RQRR-----KPIF------TERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKE------ 1347
            ||..     |.:|      .|::|.|:.::.:..   .::..:|:.|  |...|...||
Zfish   852 RQEEETAQLKEVFRRELEKAEQEIKKTTAIIAEY---KQICSQLSTR--LEKQQASTKEELDIVK 911

  Fly  1348 -KTPFFEQLRQQQQQHRLNGGGQSSNVGESGSP---TPPSRPNRLLDNASARTVMQVKLDELKLP 1408
             |....|:.|:               |.....|   .|.|:.||..|....:..::.:|.||:|.
Zfish   912 AKVMACERCRE---------------VFSKDGPLQIPPVSQDNRDTDLDEEKDSLKAQLRELELE 961

  Fly  1409 EHVDKFVANIKSPL--------EVDSGVGTPLSPPSTASNS 1441
                  :|..|..|        |::...|..::....|.||
Zfish   962 ------LAQTKLQLVEAKCKIQELEHQRGVLMTEVQAAKNS 996

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	43/233 (18%)
		DUF3350	831..880	CDD:463365	5/66 (8%)
		TBC	933..1152	CDD:214540	78/218 (36%)
		COG4372	<1190..>1353	CDD:443500	34/181 (19%)
rabgap1l	XP_073792904.1	None