Protein Alignment plx and TBC1D2

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001254500.1
• Gene: TBC1D2 / 55357
• HGNCID: 18026
• Length: 928
• Species: Homo sapiens
• Alignment Length: 949
• Identity: 193/949 - (20%)
• Similarity: 341/949 - (35%)
• Gaps: 277/949 - (29%)

  Fly   359 GGVGIEA--KPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDN 421
            |.||:.|  :|..:|::..||....|  .|:..|:...:.||      |.||.|.     |.||:
Human   189 GLVGVAAALQPFPALQNISLKHLGTE--IQNTMHNIRGNKQA------QGTGHEP-----PGEDS 240

  Fly   422 KENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASAS 486
            .::..|::.                   .||||  |....|.......|.|.....:....|..:
Human   241 PQSGEPQRE-------------------EQPLA--SDASTPGREPEDSPKPAPKPSLTISFAQKA 284

  Fly   487 AGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKD 551
            ...:...|.:             |:|     :.:|||....|...:        :|||:
Human   285 KRQNNTFPFF-------------SEG-----ITRNRTAQEKVAALE--------QQVLM------ 317

  Fly   552 VASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIF 616
                            :.:||          |.|.|     :|..:.:|.:...::|:.....:.
Human   318 ----------------LTKEL----------KSQKE-----LVKILHKALEAAQQEKRASSAYLA 351

  Fly   617 SCEHCPMLWYHKLCTDVEGLSEKKTQ-ALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQF 680
            :.|....|         |.:..|..| |.:.||:|.|..:.:.:
Human   352 AAEDKDRL---------ELVRHKVRQIAELGRRVEALEQERESL--------------------- 386

  Fly   681 LMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVP 745
                  ||..|.:::.|.:..::....:::......:..|....:|..|.:...:.|.:.|.|
Human   387 ------AHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQSPLRPDAA-- 443

  Fly   746 SHNLRDI--REGSAEPLGTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAE 808
               .||.  ::|..|.|  :...|.:|::                             |....:|
Human   444 ---NRDFLSQQGKIEHL--KDDMEAYRTQ-----------------------------NCFLNSE 474

  Fly   809 THQGS--WRQAILNSVVTPSKGL----------DSEVPTEFLSPMRKPAKRGKRDAAELRELWRT 861
            .||.:  ||:     |....|.|          :.:|.:::|:.:|:..:....:|:|..||.|.
Human   475 IHQVTKIWRK-----VAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQ 534

  Fly   862 AIRQTIMLNRMETENAMLQ----ARQNENELKRIKLDYE-----------------------EIV 899
            .:::.:.....|..:..::    ::.:|.....:. |||                       |.|
Human   535 LVQEALQWEAGEASSDSIELSPISKYDEYGFLTVP-DYEVEDLKLLAKIQALESRSHHLLGLEAV 598

  Fly   900 PCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKR 964
              |:.|.|||        ..:|:......|...:|.||||..|..||.:|..           .|
Human   599 --DRPLRERW--------AALGDLVPSAELKQLLRAGVPREHRPRVWRWLVH-----------LR 642

  Fly   965 FPNFNTP--YHMLLKHLTEHQH----AIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDP 1023
            ..:.:||  |..||......:|    .|.:||.|||||::.:..|.......|..:|.|:|..:|
Human   643 VQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNP 707

  Fly  1024 ELGYCQGLGFICGVLLLHCDEANS-FQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLP 1087
            .:||||||..:..:.||..:|..| |..|..::........|...:...|:....|..|:.:.||
Human   708 TIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLP 772

  Fly  1088 DLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL 1152
            .|...|.|:.|..:|....|.|.||:.......:.||:|....|.:.|:|::|:|:...:::::|
Human   773 RLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEIL 837

  Fly  1153 AKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIG----KQLAEYKVEYNVLQEEITTTNHHL 1213
            ...|..||..||:.....:.::  .::|.:.|: |:.    |||.:                  |
Human   838 RLQNGLEIYQYLRFFTKTISNS--RKLMNIAFN-DMNPFRMKQLRQ------------------L 881

  Fly  1214 EMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQIT 1252
            .|::||:     ||.:|:..:...|:....|:|::..::
Human   882 RMVHRER-----LEAELRELEQLKAEYLERRASRRRAVS 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	46/243 (19%)
		DUF3350	831..880	CDD:463365	9/48 (19%)
		TBC	933..1152	CDD:214540	65/225 (29%)
		COG4372	<1190..>1353	CDD:443500	13/63 (21%)
TBC1D2	NP_001254500.1	SMC_prok_B	<276..480	CDD:274008	50/338 (15%)
		Interaction with RAC1. /evidence=ECO:0000269|PubMed:20116244	295..433		34/223 (15%)
		TBC	625..837	CDD:214540	64/222 (29%)
		Interaction with CADH1	1..169
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..39
		PH_TBC1D2A	47..147	CDD:269966
		Atrophin-1	<183..>292	CDD:460830	30/136 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	225..275		18/81 (22%)