DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and evi5b

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	XP_009300706.2	Gene:	evi5b / 553306	ZFINID:	ZDB-GENE-041111-244	Length:	837	Species:	Danio rerio

Alignment Length:	691	Identity:	162/691 - (23%)
Similarity:	303/691 - (43%)	Gaps:	149/691 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   771 SRSNTVG------ASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGL 829
            |.|:||.      |:|||..|.....:..:       :||..|...|           ::|.
Zfish    21 SVSHTVSQMASQVATPSSLHTTVASSTASL-------SSPSSASPTQ-----------LSPD--- 64

  Fly   830 DSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLD 894
                ..|.|:.:.:..:..:.|:..||         ::..:|..:.::::.:....:.|..::
Zfish    65 ----DVELLAKLEEQNRLLETDSKSLR---------SVNGSRRNSGSSLVSSSSASSNLSHLE-- 114

  Fly   895 YEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAP 959
             |:......:::..||.:         .||..|.|...:|.|||...|..||..|....::   |
Zfish   115 -EDSWILWGRIVNEWEDV---------RKKKEKQLKELVRKGVPHHFRAIVWQLLCNAQNL---P 166

  Fly   960 VDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPE 1024
            :..:        |..|||..:..:..|..|:.||:|.|:|:|:...|||..|||::||||::|.|
Zfish   167 IKEQ--------YSELLKMTSPCEKLIRRDIARTYPEHEFFKEKDSLGQEVLFNVMKAYSLVDRE 223

  Fly  1025 LGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDL 1089
            :|||||..||.|:||:...|..:|.:...||....:|..:.|.|.:..|.:||...::::.||:|
Zfish   224 VGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQEYRLRELFKPSMAELGLCMYQFECMIQEQLPEL 288

  Fly  1090 YVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAK 1154
            :|.........::||:.|.||:|.:.|||....|:||:...|..:::|:..:|:|.:::.:|:..
Zfish   289 HVHFQAQSFHTSMYASSWFLTIFLTSFPLPVATRIFDIFMCEGLEIVFRVGMAILQMNQAELMQL 353

  Fly  1155 DNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNV-----LQEEITT--TNHH 1212
            | .|.::.:.:.|:|....:..:::::           |.|:|:||.     |::|.||  |...
Zfish   354 D-MEGMLQHFQKVIPHQLDSGPDKVIQ-----------AAYQVKYNAKKMKKLEKEYTTIKTKEM 406

  Fly  1213 LEM--LNREKTQNQHLEQQLQFAQSSIAQL-------ETTRSSQ-------QAQITTLQSQVQSL 1261
            .|.  :.|.:|:|:.|:|::...:...|.|       :.||:.:       :.::.|::..::..
Zfish   407 EEQVEIKRLRTENRLLKQRIDTLEKESASLADRLIQGQVTRAQEAEENYLVKRELATVKQHIEET 471

  Fly  1262 ELTIQTLGRYVGQL----VEHNPD------LELPNEV----------RRMLQQLDD--LDRQRRK 1304
            .:.::.....:.||    .:.||.      |:|..|:          :..|:::.|  ||.::|.
Zfish   472 SVQLEQAQSTIRQLQQPFAKGNPRYTEESILQLERELVQARLKEAESQCALKEMQDKILDMEQRN 536

  Fly  1305 PIFTERKIGKSVSVNSHL-GFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGG 1368
            ....:.  ...|.:...| |..|:..|.||...||   ::|.::       |.:..|:|.....|
Zfish   537 TSLPDE--NNVVRLQEELIGVKLREAEALTGLKEL---RQQVRD-------LEEHWQRHLARTAG 589

  Fly  1369 QSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPE 1409
            :..:     ||    |.|       |.:.:|.:|..::|.|
Zfish   590 RWKD-----SP----RKN-------AASELQDELMSVRLRE 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	6/44 (14%)
		TBC	933..1152	CDD:214540	73/218 (33%)
		RILP-like	<1176..1267	CDD:304877	21/113 (19%)
evi5b	XP_009300706.2	TBC	143..351	CDD:214540	73/218 (33%)
evi5b	XP_009300706.2	SMC_N	<389..718	CDD:330553	51/254 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R541
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940