Protein Alignment plx and TBC1D8B

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_060222.2
• Gene: TBC1D8B / 54885
• HGNCID: 24715
• Length: 1120
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 136/633 - (21%)
• Similarity: 227/633 - (35%)
• Gaps: 185/633 - (29%)

  Fly   856 RELWRTAIRQTIML----NRMETENA-MLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIER 915
            ||..:|...:.:|.    ..:||.|: ||:.:..|                     :.|:.:...
Human   424 RECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKE---------------------QSWKILFAE 467

  Fly   916 NSTQIGNKKDPKVLGHAIRTGVPRSKRGDVW-----------------TFLAEQHSMNTAPVDTK 963
            ....:...:..|.....:| |:|.:.||::|                 |.:.|| |:.|..:.|:
Human   468 CGRGVSMFRTKKTRDLVVR-GIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQ-SLGTCNLATE 530

  Fly   964 RFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYC 1028
            ....                     ||.|:.|.|..::...|:.  :|..:|.||:..:|::|||
Human   531 EIER---------------------DLRRSLPEHPAFQSDTGIS--ALRRVLTAYAYRNPKIGYC 572

  Fly  1029 QGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKY--------LPDMKKFQLQLYQLSRLVKDH 1085
            |.:..:..||||:..|..:|.||..:..|  |...|        |.|...|:       .|::||
Human   573 QAMNILTSVLLLYAKEEEAFWLLVAVCER--MLPDYFNRRIIGALVDQAVFE-------ELIRDH 628

  Fly  1086 LPDLYVWLDQNDVSPTLYAA---PWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVH 1147
            ||.    |.::....|.:::   .|.||:|.|..|:.....|.|..|.:....|.:..:|:|..:
Human   629 LPQ----LTEHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYN 689

  Fly  1148 KQQLL-AKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNH 1211
            ..:|| .||:.|.:             |.:.:....|.:.| ....:..:...||..|:.:.|..
Human   690 LDKLLTCKDDAEAV-------------TALNRFFDNVTNKD-SPLPSNVQQGSNVSDEKTSHTRV 740

  Fly  1212 HLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSL-ELTIQTLGRYVGQL 1275
            .:..|.||..:        ::.......:.:.|...:..:      :|:| |.|.|.:.|.|.|
Human   741 DITDLIRESNE--------KYGNIRYEDIHSMRCRNRLYV------IQTLEETTKQNVLRVVSQ- 790

  Fly  1276 VEHNPDLELPNEVRRMLQQLDDLDRQRRKPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGS 1340
                       :|:..||:||:|....:|.:|        :|....||.|:
Human   791 -----------DVKLSLQELDELYVIFKKELF--------LSCYWCLGCPV-------------- 822

  Fly  1341 PQKQKKEKTPFFEQLRQQQQQ-----HRLNGGGQSSNVGESGSPTPPSRPNRLLDN--------- 1391
             .|......|:.||.:...||     |.|:....|:|.......|     .||||.
Human   823 -LKHHDPSLPYLEQYQIDCQQFRALYHLLSPWAHSANKDSLALWT-----FRLLDENSDCLINFK 881

  Fly  1392 --ASARTVMQ--VKLDELKL--PEHVDKFVANIKSPLEVDSGVGTPLS 1433
              :||..:|.  ...::|||  ..|:......:||.   |:..|..||
Human   882 EFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVKSK---DASKGDELS 926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	8/28 (29%)
		TBC	933..1152	CDD:214540	60/246 (24%)
		COG4372	<1190..>1353	CDD:443500	30/163 (18%)
TBC1D8B	NP_060222.2	PH-GRAM1_TBC1D8B	156..254	CDD:275419
		PH-GRAM2_TBC1D8B	296..388	CDD:270159
		TBC	486..694	CDD:214540	60/245 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1035..1066