Protein Alignment plx and Tbc1d8

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_017177250.1
• Gene: Tbc1d8 / 54610
• MGIID: 1927225
• Length: 1160
• Species: Mus musculus
• Alignment Length: 1004
• Identity: 187/1004 - (18%)
• Similarity: 341/1004 - (33%)
• Gaps: 297/1004 - (29%)

  Fly   607 QKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSE--K 669
            |.|::|...|       |...::...:|.|::...:.|:...:..|..|.||       .|:  |
Mouse   240 QNKERDFSTF-------LNLDEVFKIMEQLADVTLRRLLDNEVFDLDPDLQE-------PSQITK 290

  Fly   670 TNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAE-------NRSEFLNQYLGGSTIFMKAKR---- 723
            .:.....||:|    .||.....::..:|..|:       :|.....:.....:....|.|
Mouse   291 RDLEARAQNEF----FRAFFRLPREEKLHAVADCSLWTPFSRCHTAGRIFSSDSYICFASREDGC 351

  Fly   724 -SLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSA----EPLGTQSPPEGFRSRSNTVGASP--- 780
             ::......::..:..:|...:|:..:..||...|    |....::..||...|...|.|:.
Mouse   352 CNVVLPLREVVSIEKMEDTSLLPNPIIVSIRSKMAFQFIELKDRENLVEGLLLRLKQVHANHPVH 416

  Fly   781 -SSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKP 844
             .:.|:.:.:.||:.                                  ..:.:.|:....:...
Mouse   417 YETSPSDDDMASPVF----------------------------------YSASICTDKFGDLEMV 447

  Fly   845 AKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERW 909
            |.:...:..|.|.           |...|...|:.|  |:.::....:|..|:|      .|..|
Mouse   448 ASQSSEEREEKRP-----------LPHPEPLTAVFQ--QSGSQSPDSRLSREQI------KISLW 493

  Fly   910 -EQIIE--RNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTP 971
             :..:|  |.......:|..|:    :..|:|.|.||.:|...::      |..|....|.:
Mouse   494 NDHFVEYGRTVCMFRTEKIRKL----VAMGIPESLRGRLWLLFSD------AVTDLASHPGY--- 545

  Fly   972 YHMLLKH-------LTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQ 1029
            |..|::.       :||.   |..||.|:.|.|..:::..|:.  :|..:|.||:..:|::||||
Mouse   546 YGNLVEQSLGRCCLVTEE---IERDLHRSLPEHPAFQNETGIA--ALRRVLTAYAHRNPKIGYCQ 605

  Fly  1030 GLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQL---QLYQ--LSRLVKDHLPDL 1089
            .:..:..||||:..|..:|.||..:..|      .|||....::   |:.|  ...|:|:.||:|
Mouse   606 SMNILTSVLLLYAKEEEAFWLLVAVCER------MLPDYFNHRVIGAQVDQSVFEELIKEQLPEL 664

  Fly  1090 YVWLDQNDVSP-TLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL- 1152
            ...:  :|:|. ...:..|.||:|.|..||.....|.|..|.:....||:..:|:|..:.::|.
Mouse   665 AEHM--SDLSALASISLSWFLTLFLSIMPLESAVHVVDCFFYDGIKAIFQLGLAVLEANAEELCS 727

  Fly  1153 AKDNFEEIM------DYLKT----------------------------------------VVP-- 1169
            :||:.:.:|      |::|.                                        .||
Mouse   728 SKDDGQALMVLSRFLDHIKNEDSPGPPIGSHHAFFSDDQEPYPVTDIADLIRDSYELWTQAVPVS 792

  Fly  1170 ----------KMEH-TCMEQIMKLVFSMDIGKQ--LAEYKVEYNVLQEEITTT------------ 1209
                      ::|| .|..:|..|....|..||  |.....|.::|.|::...
Mouse   793 MQKFGNQSVEQIEHLRCKHRIRVLQGHEDTTKQNVLRVVIPEVSILPEDLEELYDLFKRAHMMSC 857

  Fly  1210 --NHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRY- 1271
              .||..|..|......:.||.         :::..:.:...|:.:..:.....|:..:.|.|.
Mouse   858 YWEHHRPMALRHDPSRPYAEQY---------RIDARQFAHLFQLVSPWTCGVHTEILAERLFRLL 913

  Fly  1272 ---VGQLVE-----------HNPDLELPNEVRRMLQQL--------DDLDRQ---------RRKP 1305
               :.||:|           :|.::   ||..::|.:|        :|.|.|         ..:|
Mouse   914 DDNMDQLIEFKAFTSCLDIMYNGEM---NEKIKLLYRLHIPPALTENDRDSQSPLKNPLLSTSRP 975

  Fly  1306 IFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPF----FEQLRQQQQQHRL-- 1364
            :...:..|.::.....|...:|.|.:..::.|...|:..::|...|    :....:..:::.|
Mouse   976 LVLGKPNGDTIDYQKQLKQMIKDLAKEKDKMEKELPKMSQREFIQFCKTLYSMFHEDPEENDLYQ 1040

  Fly  1365 --------------------NGGGQSSNVGESGSPTPPSRPNRLLD---------------NASA 1394
                                :.|..|....|..:..||.:.:...:               ..|.
Mouse  1041 AIATVTTLLLQIGEVGQRGSSSGSCSQECEEPQASAPPEQDSVFAEAGKSPQAFPETEGDWTVSL 1105

  Fly  1395 RTVMQVKLDELKLPEHVDKFVANIKSPLE 1423
            ..::...|.|..|....:| ..||||.||
Mouse  1106 EHILASLLTEQSLVNFFEK-PLNIKSKLE 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	7/48 (15%)
		TBC	933..1152	CDD:214540	64/231 (28%)
		COG4372	<1190..>1353	CDD:443500	36/214 (17%)
Tbc1d8	XP_017177250.1	PH-GRAM1_TBC1D8	171..269	CDD:270156	7/35 (20%)
		PH-GRAM2_TBC1D8	311..406	CDD:270160	13/94 (14%)
		TBC	519..725	CDD:214540	64/227 (28%)