DRSC/TRiP Functional Genomics Resources

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Protein Alignment plx and TBC1D3C

DIOPT Version :10

Sequence 1:NP_001163511.1 Gene:plx / 40704 FlyBaseID:FBgn0261261 Length:1572 Species:Drosophila melanogaster
Sequence 2:XP_006721967.1 Gene:TBC1D3C / 414060 HGNCID:24889 Length:610 Species:Homo sapiens


Alignment Length:424 Identity:94/424 - (22%)
Similarity:155/424 - (36%) Gaps:102/424 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   753 REGSAEPLGTQSPPEGFRSRSNTVG------ASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQ 811
            |.|..|..|    |:.|||.:|.|.      :.||.:...::...|...:               
Human    27 RAGLPEDKG----PKPFRSYNNNVDHLGIVQSCPSWESAPQEGPCPPFPV--------------- 72

  Fly   812 GSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIM-------- 868
                         ||.||..|:..:..||                 .|.:|.|...:        
Human    73 -------------PSPGLSPELERDRASP-----------------FWGSAPRLGPLQAPCSSSA 107

  Fly   869 ---LNRMETENAMLQARQNENELKRIKLDYEEIVPCDK--QLIERWEQIIERNSTQIGNKKDPKV 928
               |...|||...|.||    |.|:|:   .||....|  .::..||:.          |...|:
Human   108 LPGLPYSETELPPLTAR----EAKQIR---REISRKSKWVDMLGDWEKY----------KSSRKL 155

  Fly   929 LGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLL----KHLTEHQHAIFID 989
            :..|.: |:|.:.||.:|:.|     :||..:..|     |...:.::    |..:||...|..|
Human   156 IDRAYK-GMPMNIRGPMWSVL-----LNTEEMKLK-----NPGRYQIMKEKGKRSSEHIQRIDRD 209

  Fly   990 LGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHL 1054
            :..|...|.|::|..|..|..|.::|.||...:||:|||:.|..|..:.||:..|.::|..|..|
Human   210 VSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQL 274

  Fly  1055 MF--RRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFP 1117
            :.  |.:::..:.|:....|....|...:|....|......|:.|:.........::.:......
Human   275 LASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGIS 339

  Fly  1118 LGFVARVFDLLFLESSDVIFKFAIALLSVHKQQL 1151
            ||...|::|:..:|....:.........|.:::|
Human   340 LGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRL 373

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plxNP_001163511.1 PTB_TBC1D1_like 301..601 CDD:269967
DUF3350 831..880 CDD:463365 10/59 (17%)
TBC 933..1152 CDD:214540 53/225 (24%)
COG4372 <1190..>1353 CDD:443500
TBC1D3CXP_006721967.1 TBC 160..373 CDD:214540 52/223 (23%)
PHA03381 <417..>529 CDD:177618
Blue background indicates that the domain is not in the aligned region.

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