DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment plx and wkd

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	NP_650089.1	Gene:	wkd / 41390	FlyBaseID:	FBgn0037917	Length:	363	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	93/372 - (25%)
Similarity:	158/372 - (42%)	Gaps:	80/372 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   893 LDYEEIVPCDKQ---LIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHS 954
            |...:|:..:|:   :|:.|...:.:|..:|.::         .|.|:|:|.|...|.:|:..:.
  Fly    40 LSKAQIIAREKKWLYMIDNWSIYMSKNYKKIRDR---------CRKGIPKSVRPKAWFYLSGAYL 95

  Fly   955 MNTAPVDTKRFPNFNTPYHMLL---------KHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLS 1010
            :.      |:.||.   |:.||         :.:.:.:|       |.||.|:.:.|...:||:.
  Fly    96 LK------KKNPNV---YNELLEKPGNPTTIEEIKKDKH-------RQFPFHEMFLDEQKVGQIE 144

  Fly  1011 LFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHL--MFRRNMRTKYLPDMKKFQL 1073
            |||:||||||.:|::|:||....|...||:|....::|.:...:  ::   ::..::|.::..|.
  Fly   145 LFNVLKAYSIYNPKVGFCQAQAPIAAFLLMHLPAEDAFWVFVSVCDVY---LQDYFIPGLEVIQN 206

  Fly  1074 QLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFK 1138
            ....|..|:|...|.:|..|.::.|.|.||...|.|...:...|...:.||:|....|...||||
  Fly   207 DAGILEGLLKKTCPPVYRHLQKHKVEPLLYMTDWFLCAMTRTLPWETLLRVWDCFLAEGIRVIFK 271

  Fly  1139 FAI----ALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYK-VE 1198
            .|:    |.||.|                      |:..||          ..:.:.||..: .|
  Fly   272 VALVIIGASLSRH----------------------KVRKTC----------TGLCETLAVLRSPE 304

  Fly  1199 YNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRS 1245
            .::::||....|.....|..|..|.:|..|:.:.|:.. ||.|...|
  Fly   305 EHIVEEEFIINNMMRLNLRVEDFQIEHTRQKARRAKQK-AQQEAESS 350

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663
		TBC	933..1152	CDD:214540	67/233 (29%)
		RILP-like	<1176..1267	CDD:304877	16/71 (23%)
wkd	NP_650089.1	RabGAP-TBC	114..277	CDD:366170	50/172 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456551
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940