DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and CG7324

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	NP_649305.1	Gene:	CG7324 / 40361	FlyBaseID:	FBgn0037074	Length:	1291	Species:	Drosophila melanogaster

Alignment Length:	1088	Identity:	231/1088 - (21%)
Similarity:	383/1088 - (35%)	Gaps:	329/1088 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   715 STIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSP-PEGFRSRSNTVGA 778
            :||::|...::|.:|..|.  ..|...:.:...|...|::...:|   .|| .:...|..:.:|:
  Fly   204 NTIYLKTTNNMTYNFTMLF--NASDAHLLIEQLNKMAIQQLIHDP---DSPVVDHDTSNFSRLGS 263

  Fly   779 SPSSKP------TAEQLKSPMMDIFIKVGNS-------------PKEAETHQG---------SWR 815
            ..|.||      ||.| ||....|:.::..|             |.....:.|         .:|
  Fly   264 KTSKKPVLLRDLTARQ-KSEEFRIYFRLPQSEIIDGKIKANIWTPYSKRFNSGFIYLSPNFFCFR 327

  Fly   816 QAI--LNSVVTPSKGLDS---------------------EVP----------------TEFLSPM 841
            ..:  |.|||.|.|.:.|                     .||                |:.|:.:
  Fly   328 SDVKDLVSVVIPMKTIKSVEKKDDGQQRFENQIVIITSENVPFMFAHIVDRAVLISKITDLLARV 392

  Fly   842 RKP--AKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQ 904
            ..|  .:|.|.|.:     |.   :||.::|..:|:.:                  .||:...::
  Fly   393 HVPLSRERAKYDIS-----WS---KQTALMNTFKTQFS------------------AEIIQKQEE 431

  Fly   905 LIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVW-TFLAEQHSMNTAPVDTKRFPNF 968
            .:.|||.........||..:...|: :.|..|:|...|.::| .|....|       |.:..|..
  Fly   432 KMVRWEAHFRDFGRGIGMFRTTDVI-NLIVEGIPDKLRQEIWLIFSGAIH-------DKEMNPGL 488

  Fly   969 NTPYHML------LKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGY 1027
               |..|      :|:...|.. |..||.|:.|.|..::...|:|  :|..:|:||::.:|::||
  Fly   489 ---YEDLVEKAACIKNCFAHDE-IDRDLPRSLPEHPAFQSTDGIG--ALRRVLQAYALRNPQVGY 547

  Fly  1028 CQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQ--LSRLVKDHLPDLY 1090
            ||.:..:..|.||.|||.|:|.:|..|.  .|:...|..| |....|:.|  |:.||:.|||||:
  Fly   548 CQAMNIVSSVFLLFCDEENAFWMLASLC--ENLLPDYYKD-KVVGAQIDQGVLNELVETHLPDLH 609

  Fly  1091 VWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL-AK 1154
            ..|:|..|. .:.:..|.||:|.|.........:.|..|.|.:.:||..::.::..::.:|| .:
  Fly   610 GHLEQLGVI-KMISISWFLTIFMSVISYESSLHILDCFFYEGAKIIFMISLQIIEWNRDKLLICQ 673

  Fly  1155 DNFEEIM---DYLKTV------VP------KMEHTCMEQIMKLVFS---MDIGKQLAEYKVEYNV 1201
            |:.|.::   :||:.|      ||      |||.....|.::.:..   ...|:.:.:.::
  Fly   674 DDGEAMLVLQNYLEGVYNPEYQVPPTTDKRKMERKVQTQTVQTLIHEAYTKFGEDITQQRI---- 734

  Fly  1202 LQEEITTTNHHLEM----LNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLE 1262
              ||:...:..|.|    ::.|||..:...|...|.:|.:..|.|....::..:.:||.|.|.::
  Fly   735 --EELRNKHRRLTMRQFDIDNEKTIVKAYVQNPYFNRSELHMLLTIIREEKHALKSLQQQQQKVQ 797

  Fly  1263 LTIQTLGRYVGQLVEHNPDLELPNEVRRMLQ---------QLDDLDRQRRKPIFTE----RK--- 1311
            ..:           ...|.| :|....|.:|         :...:..:....:|||    ||
  Fly   798 CPL-----------SETPQL-VPQSTSRPIQDAGASGGRYEAYSVSYEVFHTLFTELTPWRKCVS 850

  Fly  1312 --IGKSV----------------SVNSHLGF--------PLKVLEEL----------TERDELGS 1340
              ||:.:                .:|: ||.        .||:|..|          .||.....
  Fly   851 VDIGEKLFRLTDKKGTGVLDFGQLINA-LGLVCSNKNMEKLKLLYVLHLPPLLSKAEIERSRRPR 914

  Fly  1341 PQ-----KQKKEKTPFFEQLRQQQQ----------------------QHRLNGGGQSSNVGESGS 1378
            |:     ::..|...||:....:..                      ||..|..|.|.|.....|
  Fly   915 PRTKDDAEEAFEAEDFFDNDASESMEALPSPSDHNFDADDFALISATQHLHNLAGISGNTFMDLS 979

  Fly  1379 PTPPSRPNRLLDNASAR-TVMQVKL----------------DELKLP-------EHVDKF----- 1414
            .||....|....:.:.| :...|.|                |||:..       |.:|.|
  Fly   980 RTPNLSVNSNTSSLAHRSSTFYVDLPGFQGTATSTDAGRDEDELQRQLRQQGRYESIDTFSDISD 1044

  Fly  1415 --VANIKSPLEVDSGVGTP--------------LSPPSTASNSS------GGSIFSRMGYRTTP- 1456
              .|.|..|   ::|||..              |....|.||.|      ..:...|:....|.
  Fly  1045 LGAARITPP---EAGVGADVVAGAASSAAADHMLLNVETISNFSQISDLVAATRLERVDSNATDL 1106

  Fly  1457 ---PALSPLAQRQSYGVAITTAPCPQHME----EVAPATTMAVMPQEDVEEPQPMHPLSMVGGDV 1514
               .:|..|..:...|.:.:....| ||.    ::...:.:.:|.....||.|..:...:..|:.
  Fly  1107 RSLGSLGYLLDQPDEGASNSQHSIP-HMRKENFQLLWRSIIEIMGLVQDEEMQRAYENLLELGNS 1170

  Fly  1515 NVR----FKGTTQLKSIRPVHHMRAIPLGGVQHPSSTEPAVRVAPVPV 1558
            |::    .:..|||.            :||.:.|.|.......||.|:
  Fly  1171 NIKKEPSLESFTQLN------------MGGDEQPDSNGNPTTPAPEPI 1206

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	11/46 (24%)
		TBC	933..1152	CDD:214540	67/227 (30%)
		RILP-like	<1176..1267	CDD:304877	18/97 (19%)
CG7324	NP_649305.1	PH-GRAM1_TCB1D8_TCB1D9_family	147..249	CDD:275404	10/49 (20%)
		PH-GRAM2_TCB1D9_TCB1D9B	293..389	CDD:270161	14/95 (15%)
		TBC	462..670	CDD:214540	66/224 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456555
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940