Protein Alignment plx and Tbc1d2

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_006538109.1
• Gene: Tbc1d2 / 381605
• MGIID: 2652885
• Length: 923
• Species: Mus musculus
• Alignment Length: 889
• Identity: 177/889 - (19%)
• Similarity: 310/889 - (34%)
• Gaps: 261/889 - (29%)

  Fly   402 VQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIV 466
            :.|:..|.|.......:..||:.::....||:....|    ..|...|.||     .:..|::..
Mouse   209 ISLKHLGTEIQNTMHNIRGNKQAQAAAHGPLVEDSPQ----GGEPQSGEQP-----SISDPSLPA 264

  Fly   467 NKQPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIP-----KQRDRSASQGCIPPYVEQNRTMVF 526
            .|:   |.|.......:|..:||:| .|....:..|     ..|.|:|.:
Mouse   265 EKE---PEDPAKSAPRSSVPSGPTQ-KPKRQSNTFPFFSDGLARSRTAQE--------------- 310

  Fly   527 LVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCD 591
                   ::.:.:::.::|.|:.|       .||
Mouse   311 -------KVAALEQQVLMLTKELK-------SQK------------------------------- 330

  Fly   592 DIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDE 656
            ::|..:.:|.:...::|:.....:.:.|                                 ..|.
Mouse   331 ELVIILHKALEAAQQEKRASSAYLAATE---------------------------------DRDR 362

  Fly   657 QEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTA--ENRSEFLNQYL------- 712
            .|:|..|.       ..:||.||.:..|     |..::|..|:..  |.:.:.|.|::
Mouse   363 LELVRHKV-------RQIAELNQRVEAL-----EQGRERLAHEAGLREQQVQALQQHVQLLMDKN 415

  Fly   713 -GGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTV 776
             ....:..|..:.||             :|:|.|:                          ..|.
Mouse   416 HAKQQVICKLTQKLT-------------EDLAQPA--------------------------DATN 441

  Fly   777 GASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGS--WRQAILNSVVTPSKGL---------- 829
            |...|.:...|.||..|.  ..:..|....:|.||.:  ||:     |....|.|
Mouse   442 GDFLSQQERMEHLKDDME--AYRTQNRFLNSEIHQVTKIWRK-----VAEKEKALLTKCAYLQAR 499

  Fly   830 DSEVPTEFLSPMRKPAKRGKRDAAELREL----------WRTAIRQTIMLNRM------------ 872
            :.:|.:::|:.:|:..:....:|.:..||          |......::.|:.:
Mouse   500 NCQVESKYLAGLRRLQEAAGAEAGDFPELLQQLIQEALQWEAGEADSVGLSPVSEYDDYGFLTVP 564

  Fly   873 --ETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRT 935
              |.|:..|.|:....|::...|...|.|  ::.|.:||..:     |::....:.|.|   :|.
Mouse   565 DYEMEDLKLLAKIQALEVRSHHLLAHEAV--ERPLRDRWATL-----TELTPSAELKQL---LRA 619

  Fly   936 GVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTP--YHMLLK--HLTEHQHA--IFIDLGRTF 994
            ||||..|..||.:|..           :|..:...|  |..||.  ...||..|  |.:||.|||
Mouse   620 GVPREHRPRVWRWLVH-----------RRVRHLQAPGCYQELLARGRACEHPAARQIELDLNRTF 673

  Fly   995 PNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHC-DEANSFQLLKHLMFRR 1058
            |.::.:..|.......|..:|.|:|..:|.:||||||..:..:.||.. ||.::|..|..::...
Mouse   674 PTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETI 738

  Fly  1059 NMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVAR 1123
            .....|...:...|:....|..|:.:.||.|...|.|:.|..:|....|.|.||:.......:.|
Mouse   739 LPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTAHLGQHRVDLSLITFNWFLVVFADSLISDILLR 803

  Fly  1124 VFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYL----KTVVPKMEHTCMEQIMKLVF 1184
            |:|....|.:.|:|::|:|:...:::.:|...:..||..||    ||:...      .::|.:.|
Mouse   804 VWDAFLYEGTKVVFRYALAIFKYNEEAILQLQDSLEIYQYLRFFTKTICDS------RKLMSIAF 862

  Fly  1185 SMDIG----KQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQ 1224
            : |:.    |||.:.:..:   :|.:......||:|..|..|.:
Mouse   863 N-DMNPFPMKQLRQLRAAH---RERLEAELRELELLKVEYLQRR 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	31/203 (15%)
		DUF3350	831..880	CDD:463365	10/72 (14%)
		TBC	933..1152	CDD:214540	65/225 (29%)
		COG4372	<1190..>1353	CDD:443500	9/35 (26%)
Tbc1d2	XP_006538109.1	PH_TBC1D2A	45..146	CDD:269966
		PRK12323	<192..404	CDD:481241	47/312 (15%)
		COG4913	<307..>464	CDD:443941	38/302 (13%)
		TBC	620..832	CDD:214540	64/222 (29%)