DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and CG8155

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	NP_611029.3	Gene:	CG8155 / 36698	FlyBaseID:	FBgn0034009	Length:	1098	Species:	Drosophila melanogaster

Alignment Length:	789	Identity:	162/789 - (20%)
Similarity:	256/789 - (32%)	Gaps:	271/789 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   762 TQSPPEGFRSRSNT---VGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILN--- 820
            |::.|    .||.|   ..|:|:....|.:|.||:..:    |.|.|..:..|.....:|||
  Fly   115 TEASP----GRSITGAPAPATPAPFVPARELMSPLQSL----GVSQKYVQHMQTKLGSSILNQME 171

  Fly   821 ---SVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQAR 882
               |:|..:..|..|.....  |.|.|     ...:|.| |:..|:.|.
  Fly   172 KTFSIVQKAFNLSEEHMANL--PPRPP-----MCDSEFR-LFLDALGQI---------------- 212

  Fly   883 QNENELKRIKLDYEEIVPCDKQLIERWEQII---------------------ERNSTQIGNKKDP 926
            |.::||.|: :....|.|..::::  |:.::                     .|.|.|....:|
  Fly   213 QRKDELHRV-IFLGGIDPSLRRVV--WKHLLNVYPGGANGLALDGHQRMEFMRRKSEQYCRLRD- 273

  Fly   927 KVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLG 991
                    |.....|||.|...||...||      .|:                        |:.
  Fly   274 --------TWKAAVKRGSVAGELAYVTSM------VKK------------------------DVL 300

  Fly   992 RTFPNHQFY---KDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHC-DEANSFQLLK 1052
            ||...|.||   .|...:.  :|||:|..|::..|.:.||||:..|...||:.. |||.::....
  Fly   301 RTDRLHPFYAGSDDNQNIA--ALFNILTTYALNHPSVSYCQGMSDIASPLLVTMNDEAQAYICFC 363

  Fly  1053 HLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFP 1117
            .:|.|  ||..::.|......:...|:..:..:.|:.:.:|........|:...|:|.....:||
  Fly   364 AIMSR--MRGNFMLDGIAMTQKFAHLTEALSFYDPEFWEYLKSQQADDLLFCYRWLLLELKREFP 426

  Fly  1118 LGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAK-DNFEEIMDYLKTVVPKMEHTCMEQIMK 1181
                               |:.|:.:|.|....|..: |..:|:..:.|..||
  Fly   427 -------------------FEDALRMLEVQWSSLRYRCDGEKELALFEKEFVP------------ 460

  Fly  1182 LVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSS 1246
             :....:....:.:...|:.                 ..|...:|             |...|.|
  Fly   461 -ITDASVPNSASTFSSSYSA-----------------TPTSPSYL-------------LTKPRES 494

  Fly  1247 QQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDD---------LDRQR 1302
            ...::..|:.|..|..|:  :|...||  ..|..|     ..:|:...|||         ..|||
  Fly   495 PYTKVCALRRQSSSASLS--SLSSSVG--TSHGLD-----NTKRLNHSLDDNMSRHATAAARRQR 550

  Fly  1303 RKPIFTERKIGKSVSVNSHLGFPLKVLE-------------ELTERDELGSPQKQKK--EKTPFF 1352
            |    |..|:.:|:..:..|......|:             |.||.|::...::...  |..||.
  Fly   551 R----TSAKVHQSLDESKMLALIEGALDNRNVKLEQNLSAGEETEDDDVFDRKESPSFLETNPFK 611

  Fly  1353 EQLRQQQQQHRLNGGGQSSNVGESGSPTPPSRPNR--LLDNASARTVMQVKLDE------LKLPE 1409
            :..::..::                ..|||..|.|  |..::|:      .|||      .||..
  Fly   612 DDAQRAPER----------------ETTPPVSPGRAFLCSSSSS------NLDEDPSDRKAKLQH 654

  Fly  1410 HVDKFVANIKSPLEVDSGVGTPLSPPSTA----SNSSGG---------SIFSRMGY--------- 1452
            .....|:||     :...:.|..|..|.:    |.||||         :..||:|.
  Fly   655 KNIMTVSNI-----IAKQLATNASQVSESMKRVSTSSGGHFKDLKEKLAASSRIGISFDGEGEDD 714

  Fly  1453 --RTTPPAL 1459
              |..||.|
  Fly   715 GDRKMPPKL 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	8/44 (18%)
		TBC	933..1152	CDD:214540	50/222 (23%)
		RILP-like	<1176..1267	CDD:304877	10/90 (11%)
CG8155	NP_611029.3	TBC	225..439	CDD:214540	57/277 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456553
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940