Protein Alignment plx and Tbc1d21

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001014232.1
• Gene: Tbc1d21 / 363072
• RGDID: 1310243
• Length: 336
• Species: Rattus norvegicus
• Alignment Length: 329
• Identity: 73/329 - (22%)
• Similarity: 127/329 - (38%)
• Gaps: 68/329 - (20%)

  Fly   869 LNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAI 933
            :..:..||: |.||::...:...|..     |.||   ..|:...:.|. .:...:| .:..:.:
  Rat     1 MTTLSPENS-LSARRSATFILEKKNP-----PIDK---AEWDSFFDENG-HLAKSRD-FICVNIL 54

  Fly   934 RTGVPRSKRGDVWTFLAEQHSMNTA-----PVDTKRFPNFNTPYHM------LLKHL----TEHQ 983
            ..|:....|.|.|.||...:|..::     .||:.|..|:|:...|      ||::|    ||.:
  Rat    55 ERGLHPLVRADAWKFLTGYYSWQSSRDERLMVDSNRRRNYNSLCQMYEKIQPLLENLHGNFTETR 119

  Fly   984 HAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSF 1048
            :.|..|:.:.:.     |||||       |:|.....|:..|    .|.::|.....:....:..
  Rat   120 NNIVYDIQKLYD-----KDPLG-------NVLVDKKKLEKTL----LLSYVCNTKAEYQRGFHEM 168

  Fly  1049 QLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVK-------DHLPDLYVWLDQ----------N 1096
            .:|..||...:..|.:|   .:|.||..:.|.::.       |.|.:|...||.          :
  Rat   169 VMLFQLMVEHDHETFWL---FQFFLQKTEHSCVINIGVGKNLDMLNNLITLLDPQFADHLKGKGS 230

  Fly  1097 DVSPTLYAAPWILTVFSSQF-PLGFVARVFDLLFLESSDVIFKFAIA---LLSVHKQQLLAKDNF 1157
            ....:|:  ||....|...| ....|.|::::|........|:..:|   |..|.:|.||...:.
  Rat   231 GAVQSLF--PWFCLCFQRAFKSFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQALLESMSG 293

  Fly  1158 EEIM 1161
            :.|:
  Rat   294 DAIL 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	2/10 (20%)
		TBC	933..1152	CDD:214540	58/254 (23%)
		COG4372	<1190..>1353	CDD:443500
Tbc1d21	NP_001014232.1	TBC	62..287	CDD:214540	57/245 (23%)