Protein Alignment plx and Tbc1d1

DIOPT Version :9

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_006251066.1
• Gene: Tbc1d1 / 360937
• RGDID: 1304562
• Length: 1257
• Species: Rattus norvegicus
• Alignment Length: 1349
• Identity: 387/1349 - (28%)
• Similarity: 580/1349 - (42%)
• Gaps: 421/1349 - (31%)

  Fly   176 PKDPLLHIYLFECEAVEEMAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHAT 240
            |.|||:...:|||:. :.:.:|:|..:||::.
  Rat    84 PWDPLICSSIFECKP-QRVHKLIHNSQDPSYF--------------------------------- 114

  Fly   241 PATNLKMSEAMRNAQHDTS-------------PNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSA 292
             |..:|     .:|.|..|             |..:||..:|.|                  .:.
  Rat   115 -ACLIK-----EDAAHQQSLCYVFKADDQTKVPEIISSIRQAGK------------------IAR 155

  Fly   293 QSNLSLLADISPNHTHFFEVMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSS 357
            |..|...::........|||::.|::.|:.|:.|...||:.:.||.....       .|::...:
  Rat   156 QEELRCPSEFDDTFAKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSC-------GRRIDWDA 213

  Fly   358 EGGVGIEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNK 422
            ..|     :||
  Rat   214 PTG-----QPS------------------------------------------------------ 219

  Fly   423 ENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASA 487
               :|..||:.:..||         .|.:.||...:.:              |..:.:.|.|
  Rat   220 ---APGARPMRKSFSQ---------PGLRSLAFRKEFQ--------------DASLRSSTFS--- 255

  Fly   488 GPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDV 552
                     :.||..:...........|..:|:||||:|.:|:.::.|||||.|::.|.|:||::
  Rat   256 ---------SFDNDIENHLIGGHNVVQPTDMEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEI 311

  Fly   553 ASCVHGQKSLDHFGIICRELNNDG-----YIGYVFKCQSEHVCDDIVAAIAQAFDTCA-EQKKKQ 611
            :.|..|.:.:||||.||||.:..|     ::.|||:|.:|.:.|:|:..:.|||...| :|..|.
  Rat   312 SFCSQGIRHVDHFGFICRECSGGGGAGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKA 376

  Fly   612 DTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAE 676
            ..|:  ||.||:...||||..:||::..||:..:.:.:.||::.||.:::.:.......|.  ..
  Rat   377 PAQL--CEGCPLQGLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQAMIFEEVQKLRPRNE--QR 437

  Fly   677 QNQFLMMLLRAHCESRQQRHVH-----DTAENRSEFLNQYLGGS-------TIFMKAKRSLTNSF 729
            :|:.::..||...|.:|:.|.|     .|.:..:|.:...|..|       ::..:||||||.|.
  Rat   438 ENELIISFLRCLYEEKQKEHSHTGEPKQTLQVAAENIGSELPPSASRFRLDSLKNRAKRSLTESL 502

  Fly   730 DNLLKR------------------------KPSKDDIAVPSHNLRDIREGSAEPLGTQ------- 763
            :::|.|                        ..:..::::.......|.|.|.:.||:.
  Rat   503 ESILSRGNKARGLQDHSASVDLDSSTSSTLSNTSKELSMGDKEALPISESSFKLLGSSDDLSSDS 567

  Fly   764 -----------SPPEGFRSRSNTVGASP----------SSKPTAEQLK----------------- 790
                       ||.:.||.|:||:...|          .:.|...|.|
  Rat   568 ESHIAEESALLSPQQAFRRRANTLSHFPVECPAPPEPAQTSPGVSQRKLMRYHSVSTETPHERNV 632

  Fly   791 ------------------------------SPMMDIFIKVGNS---------------------- 803
                                          ||....::|..:|
  Rat   633 DHLPGGESRCCPGQPSDPPPLPPRLNPSASSPNFFKYLKHNSSGEQSGNAVPKSVSYRNALRKKL 697

  Fly   804 --------------------------------------------PKEAETHQGSWRQAILNSVVT 824
                                                        |.:|..|  ||||.|...|.|
  Rat   698 HSSSSVPNFLKFLAPVDENNTCDFKNTNRDFESKANHLGDTDGTPVKARRH--SWRQQIFLRVAT 760

  Fly   825 PSKGLDS-----------EVPTEFLSPMRKPAKRG---------KRDAAELRELWRTAIRQTIML 869
            |.|..||           |:|..  ||:....:.|         |:.:.||||||:.||.|.|:|
  Rat   761 PQKACDSPSRYEDYSELGELPPR--SPLEPVCEDGPFGPVQEEKKKTSRELRELWKKAILQQILL 823

  Fly   870 NRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKK---DPKVLGH 931
            .|||.||..|||.:|:...||:|||||||.||.|::...||:::   ||. |..|   |.:.:..
  Rat   824 LRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKML---STP-GRSKIKFDMEKVHS 884

  Fly   932 AIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPN 996
            |:..||||..||::|.|||||..:. .|..:|:.|. :.||..|||.||..||||.||||||||.
  Rat   885 AVGQGVPRHHRGEIWKFLAEQFHLK-HPFPSKQQPK-DVPYKELLKKLTSQQHAILIDLGRTFPT 947

  Fly   997 HQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMR 1061
            |.::...||.|||||:|:|||||:||.|:||||||.|:.|:||||..|..:|::||.|||...:|
  Rat   948 HPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLR 1012

  Fly  1062 TKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFD 1126
            .:|.|||...|:|:||||||:.|:..|||..|::.::.|:||||||.||||:|||||||||||||
  Rat  1013 KQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEYEIGPSLYAAPWFLTVFASQFPLGFVARVFD 1077

  Fly  1127 LLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQ 1191
            ::||:.|:||||.|::||..||..:|..:|.|.|:|::|..:|.:....||:.:..||.|||.||
  Rat  1078 MIFLQGSEVIFKVALSLLGSHKPLILQHENLETIVDFIKNTLPNLGLVQMEKTISQVFEMDIAKQ 1142

  Fly  1192 LAEYKVEYNVLQEEI-----TTTNHHLEMLNREKT------QNQHLEQQLQFAQSSIAQLETTRS 1245
            |..|:|||:|||||:     .:.|..::.|  |||      ||..|.:|||.|.:.|..||.|
  Rat  1143 LQAYEVEYHVLQEELIDSSPLSDNQRMDKL--EKTNSSLRKQNLDLLEQLQVANARIQSLEVT-- 1203

  Fly  1246 SQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQ 1294
              ..::.|.:|:::...||::         :|.:..|::..|:||.:.|
  Rat  1204 --VEKLLTSESKLKQAVLTLE---------MERSALLQMVEELRRQMAQ 1241

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	65/304 (21%)
		DUF3350	835..880	CDD:288663	20/53 (38%)
		TBC	933..1152	CDD:214540	124/218 (57%)
		RILP-like	<1176..1267	CDD:304877	39/101 (39%)
Tbc1d1	XP_006251066.1	PTB	21..150	CDD:269911	19/105 (18%)
		PTB_TBC1D1_like	164..365	CDD:269967	65/304 (21%)
		DUF3350	784..834	CDD:288663	20/49 (41%)
		TBC	886..1103	CDD:214540	124/218 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	248	1.000	Domainoid score	I2070
eggNOG	1	0.900	-	-		E1_KOG4436
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	570	1.000	Inparanoid score	I1023
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D164786at33208
OrthoFinder	1	1.000	-	-		FOG0003414
OrthoInspector	1	1.000	-	-		otm44596
orthoMCL	1	0.900	-	-		OOG6_105859
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2765
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.920