DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and eat-17

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	NP_001294784.1	Gene:	eat-17 / 3565805	WormBaseID:	WBGene00020770	Length:	888	Species:	Caenorhabditis elegans

Alignment Length:	708	Identity:	164/708 - (23%)
Similarity:	287/708 - (40%)	Gaps:	172/708 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   770 RSRSNTVGASPSSKPTAEQLKSPM-MDIFIKVGNSPKEAETHQG----SWRQAILNSVVTPSKGL 829
            ||.||:. :||.:.|:  ||..|| ....::..:....|:|..|    :.....||.|
Worm    41 RSNSNST-SSPRNSPS--QLSPPMAATAALRRSSDYGSADTECGEPCETGAPVSLNEV------- 95

  Fly   830 DSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLD 894
                  :.|:.|.:..|..:.|:            :::...:..:..:...||::..|    :.:
Worm    96 ------DLLAKMEQLNKSNEEDS------------RSVASKKTGSSESRKGAREHSPE----EDE 138

  Fly   895 Y--EEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNT 957
            |  |::.....:||..||         |..||.|..:...::.|:|:..|...|      .:::.
Worm   139 YFQEDLWSVWGELILNWE---------IEVKKRPNYIKDLVKRGIPQHFRMIAW------QNLSN 188

  Fly   958 APVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILD 1022
            |.|.     :.:..|...::..:.::..|..|:.||:|...|:||. ..||..|||::||||:.|
Worm   189 ASVS-----SVHDLYSDYMRQSSVYEKVIQRDIPRTYPELDFFKDG-ERGQSLLFNVIKAYSVHD 247

  Fly  1023 PELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLP 1087
            .|:|||||..||.|:|||...|..:|.:|..||....:|..|.|.|....|.::||..||:|.:|
Worm   248 KEVGYCQGSAFIVGLLLLQMPEEEAFAVLVSLMENYRLRELYKPTMTDLGLCMFQLECLVQDQMP 312

  Fly  1088 DLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL 1152
            |||...:......::||:.|.||:|::..||....|:.|...:|..|.||..:||:|...:.:||
Worm   313 DLYTHFNNMGFDTSMYASSWFLTLFTTTMPLDIANRIMDCFLVEGMDFIFCISIAILQQARIELL 377

  Fly  1153 --------------AKDNFEEIMDYLKTV-------VPKMEHTCMEQIMKLVFSMDIGKQLAEYK 1196
                          .::.:|...|.|.||       ..:|:....:.:.|.....:...:|...:
Worm   378 RLDMEGMLKYFQREVRERYEFDADLLFTVANQVQLNAKRMKRLEKDYLTKRTKEQEEAVELRRLR 442

  Fly  1197 VEYNVLQEEITTTNHHLEM-----------------------------LNREKTQNQHLEQQLQF 1232
            .|..:|::.|    .:||.                             ||:.:..|..:.::|:.
Worm   443 TENRLLRQRI----DYLEAESSALADRLVKGQVNLAQEAENYINIAHELNKLRDMNSDVHRKLEG 503

  Fly  1233 AQSSIAQLETTR------SSQQAQITTLQSQVQSLELTIQTLGRYVGQLVE-HNPDLELPNEVRR 1290
            |..:|.:|.:.|      :..|...|::...:.||:          .:|:| |....:..|.:|.
Worm   504 AYETIRELSSARRDNIMDTGTQVDDTSMIEHIHSLQ----------QELIEAHTRQADSENTLRD 558

  Fly  1291 MLQQLDDLDRQRRKPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQL 1355
            ...::.:|:...::.:..|               |.:.:..|.|  ||.|.:.::.|.:...:::
Worm   559 AKLRVSELEMANKRLLENE---------------PSEDVAGLQE--ELISVKMREAESSLALKEM 606

  Fly  1356 RQ---QQQQH-------RLNGGGQSSNVGESGS--------PTPPSRPNRLLDNASAR 1395
            ||   :.:||       |......:|...||.|        |:||      |.:|.||
Worm   607 RQRLAELEQHWAKYVHVRAFDPSSASIEKESTSEAHSTQQQPSPP------LTSARAR 658

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	4/44 (9%)
		TBC	933..1152	CDD:214540	73/218 (33%)
		RILP-like	<1176..1267	CDD:304877	19/125 (15%)
eat-17	NP_001294784.1	TBC	170..377	CDD:214540	73/218 (33%)
eat-17	NP_001294784.1	Smc	<474..778	CDD:224117	42/218 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910