Protein Alignment plx and TBC1D26

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001375394.1
• Gene: TBC1D26 / 353149
• HGNCID: 28745
• Length: 468
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 61/290 - (21%)
• Similarity: 115/290 - (39%)
• Gaps: 39/290 - (13%)

  Fly   868 MLNRMETEN-AMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGH 931
            :::.||..: :.|:.:|...|.||               ..:|::::...:.....||    |..
Human    51 IVHEMELPHVSALEVKQRRKESKR---------------TNKWQKMLADWTKYRSTKK----LSQ 96

  Fly   932 AIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQ----HAIFIDLGR 992
            .:...:|.:.||..|:.|          :|..|..:.|...:.::|...:..    |.|.:|:..
Human    97 RVYKVIPLAVRGRAWSLL----------LDIDRIKSQNPGKYKVMKEKGKRSSRIIHCIQLDVSH 151

  Fly   993 TFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFR 1057
            |...|..:....|:.|..|.::|.|||..:||:||.:.|..|..:|||...|.::|..|..|
Human   152 TLQKHMMFIQRFGVKQQELCDILVAYSAYNPEVGYHRDLSRITAILLLCLPEEDAFWALTQL--- 213

  Fly  1058 RNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVA 1122
              :...|.|:....:..|....:::....|.:...|.:..:.........:|..|......|...
Human   214 --LAVFYSPNTAWLERLLSHQEQVLHKSFPKIMRHLGKEGLCIEGSMLTRLLRCFLDGKSFGLTL 276

  Fly  1123 RVFDLLFLESSDVIFKFAIALLSVHKQQLL 1152
            |::|:..||.:.|:.....|...:|::.|:
Human   277 RLWDVFILEGARVLTAMVHASFKIHRKHLM 306

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	2/12 (17%)
		TBC	933..1152	CDD:214540	49/222 (22%)
		COG4372	<1190..>1353	CDD:443500
TBC1D26	NP_001375394.1	TBC	98..306	CDD:214540	49/222 (22%)