Protein Alignment plx and TBC1D16

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_609403.2
• Gene: TBC1D16 / 34431
• FlyBaseID: FBgn0032249
• Length: 702
• Species: Drosophila melanogaster
• Alignment Length: 752
• Identity: 142/752 - (18%)
• Similarity: 255/752 - (33%)
• Gaps: 237/752 - (31%)

  Fly   526 FLVGRCDLRLISPDRKQVLLYKD----FKDVASCVHGQKSLDHFGIICRE----LNNDGYIGYVF 582
            |::|  |.||   |||..:.|:|    |.....|:|..       .|.|:    |:|.||:
  Fly    13 FILG--DERL---DRKIDIAYEDNEILFCKNNVCIHPP-------TIARDESDILHNPGYL---- 61

  Fly   583 KCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILR 647
                                ||..:                       |.|:..:..|...|:|.
  Fly    62 --------------------TCTTK-----------------------TFVDQYNSAKRPTLLLT 83

  Fly   648 RIETLSDDEQEIVWAKFCGSE---KTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLN 709
            .|...|..:...:.|..|..:   ::.|| ..:|.:..:.:....:.|..|...:.|.:..|..|
  Fly    84 WIPNSSLCKYTNLNADDCRGQCNPRSKSP-DSRNGYCHVTIPQTIQERDIREEDENAADMQELKN 147

  Fly   710 Q---YLGGS-------TIFMK----------------AKRSLTNSFDNLLKRKPSKDDIAVPSHN 748
            :   .|||.       |..:|                ...:::.|| |.:..:|.       |:|
  Fly   148 ELQPLLGGQAASIDDLTALLKNNPITSVNITISNPQIENSNISQSF-NCITIRPD-------SNN 204

  Fly   749 LRDIREGSAEPLG--TQSP----PEGFRSRSNTVGASPSSKPTAEQLKSPM-------------- 793
            ..|...||....|  |.:|    ||....:.|.......:...|::.||.|
  Fly   205 CSDCTNGSGVGDGPATDNPKWTTPELLAFKHNLEFPDSGNSTPADRQKSAMKCRHFSVDLSQMRS 269

  Fly   794 MDIFIKVGN--------SPKEAE-----THQG----------SWRQAILNSVVTPSKGLDSEVPT 835
            :.:|....|        :.:|::     .|.|          .|...:.|  :|...|.|
  Fly   270 LRLFFNDDNCTSGQLVIASRESQYKILHFHYGGLDHLAQVLHQWHCFLHN--ITSETGQD----- 327

  Fly   836 EFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLD--YEEI 898
            :|..|.|.                       .|:.|.|.:.:  :...:|.::|:|..:  |..:
  Fly   328 KFDLPYRH-----------------------FMVCRPEVKKS--EMHPDEGDVKKITTNFFYGTL 367

  Fly   899 VPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNT------ 957
            :. :|..||  :.::.|.....|              |:.:|.|..||.||.:.:|.::
  Fly   368 LN-EKGQIE--DDLLLRKCVFFG--------------GLEKSLRKTVWPFLLKCYSFSSTFEDRA 415

  Fly   958 APVDTKRFPNFNTPYHMLLKHLTEHQHAIF---------IDLGRTFPNHQFYKDPLGLGQLSLFN 1013
            ..:|.|| ..:.......|..::..|...|         .|:.||...:.|:..........:.|
  Fly   416 VLMDIKR-QEYEEITRKRLYSMSPEQQIHFWKTVQIVVEKDVVRTDRTNPFFCGDDNPNTEVMKN 479

  Fly  1014 LLKAYSILDPELGYCQGLGFICGVLLLHCD---EANSFQLLKHLMFRRNMRTKYL--PDMKKFQL 1073
            :|..:::.:..:.|.||:..:...:|  |:   |:.:|.....||    .|..::  |..:....
  Fly   480 ILLNFAVYNTGMSYSQGMSDLLAPVL--CEVQNESETFWCFVGLM----QRAFFVCTPTDRDVDH 538

  Fly  1074 QLYQLSRLVKDHLPDLYVWLDQ-NDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLE-SSDVI 1136
            .|..|..|::..||..|..|:| ||....|:...|:|..|..:|....|.|:::..:.. .:|..
  Fly   539 NLSYLRELIRIMLPHFYKHLEQHNDSMELLFCHRWLLLCFKREFTEAVVIRMWEACWSNYLTDYF 603

  Fly  1137 FKF-AIALLSVHKQQLLAKD--------NFEEIMDYL 1164
            ..| .:|:::|:...::|::        :|..:..|:
  Fly   604 HLFLCLAIIAVYADDVVAQNLRPDEMLLHFSSLAMYM 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	19/82 (23%)
		DUF3350	831..880	CDD:463365	6/48 (13%)
		TBC	933..1152	CDD:214540	52/241 (22%)
		COG4372	<1190..>1353	CDD:443500
TBC1D16	NP_609403.2	TBC	387..618	CDD:214540	53/251 (21%)