Protein Alignment plx and tbc1d10aa

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_009302447.1
• Gene: tbc1d10aa / 325772
• ZFINID: ZDB-GENE-030131-4497
• Length: 896
• Species: Danio rerio
• Alignment Length: 771
• Identity: 169/771 - (21%)
• Similarity: 285/771 - (36%)
• Gaps: 187/771 - (24%)

  Fly   826 SKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKR 890
            |.|.|||: ..|.| .|:..|.|....|   :.:.|.:.|.:.|       |:|:.|    |.|.
Zfish    30 SFGSDSEI-NGFTS-SRQTDKYGFIGGA---QQYSTEMAQDVPL-------AVLRHR----EAKW 78

  Fly   891 IKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSM 955
            :            .::..|::.|.:...::..:         .:.|:|.|.||..|.:|:..
Zfish    79 L------------DMLNHWDKWISKRFKKVRLR---------CQKGIPPSLRGRAWLYLSGG--- 119

  Fly   956 NTAPVDTKRFPNFNTPYHMLLKHLTEHQ------HAIFIDLGRTFPNHQFYKDPLGLGQLSLFNL 1014
                 ..||..|..     :.|.|...:      ..|..||.|.||.|:.:....|.||..||.:
Zfish   120 -----KVKREQNVG-----MFKDLDSMEGDPKWIDVIERDLHRQFPFHEMFVSRGGHGQQDLFRV 174

  Fly  1015 LKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLS 1079
            ||||::..|:.||||....|..|||:|....::|..|..:.      .||||......|:..||.
Zfish   175 LKAYTLYRPDEGYCQAQAPIAAVLLMHMPAEDAFWGLVQIC------EKYLPGYYSAGLEAIQLD 233

  Fly  1080 RLVKDHL-----PDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKF 1139
            .|:.:.|     |..|..||::.:.|.||...|.:..||...|...|.||:|:...:...:||:.
Zfish   234 GLILNALLKRVSPPAYQHLDKHKIEPILYMTEWFMCAFSRTLPWSSVLRVWDMFLCDGVKIIFRV 298

  Fly  1140 AIALLSV---HKQQLLAKDNFEEIMDYLKTVVPK--MEHTCMEQIMKL-VFSMDIGKQLAEYKVE 1198
            .:.||..   .:::|.|.....|.|:.||.:.|:  .|...:.|:|:: :.:.|:.::
Zfish   299 GLVLLKCMLGTREKLKACPGQYETMELLKALEPRYMQEAFLVHQVMEMPISARDVERE------- 356

  Fly  1199 YNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQVQSLEL 1263
                        |..::....||..       :.:..|..::...::...|:..:.|...|...:
Zfish   357 ------------HRAQLKRWRKTHG-------ELSYKSPPRMHGAQAIMSAEPHSRQDLRQKPTI 402

  Fly  1264 TIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKPIFTERKIGKSVSVNSHLGFPLKV 1328
            .:               :..||::.      ..:..|.||:.  |.||....:.:.:....|...
Zfish   403 VV---------------EYPLPSDT------TSNFARVRRRS--TIRKASSKLDIPNPYALPTDT 444

  Fly  1329 LEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGGQSSNV---GESGSPTP--PSRPNR- 1387
                  :.|:.:....:....|     ...||.|.....|:|::.   .:|..|||  ||:|.:
Zfish   445 ------QPEVETASNNQSSHPP-----SSLQQSHLTTPAGKSTSTPDPPDSVIPTPSHPSQPPKP 498

  Fly  1388 ----LLDNASARTVMQVKLDELKLPEHVDKFVANIKSPLEV--DSGVGTPLSPPSTASNSSGGSI 1446
                :..:.|..:  |...|  ..|.|          |:||  .|.: .||..|..::|::..:
Zfish   499 QPSPIFTHISPPS--QTAAD--PRPSH----------PMEVPHPSKI-EPLHNPKDSNNTNNSA- 547

  Fly  1447 FSRMGYRTTPPALSPLAQRQSYGVAITTAPCPQHMEEVAPATTM----AVMPQEDVEEPQPMHPL 1507
                 :...||..|     .|..:.|.:.|.|....::.|.:..    :.:|.|..:.|.....|
Zfish   548 -----HLKDPPHNS-----NSNPLLIESRPLPPESRQLPPESRQLPPESRLPSESRQLPLEFKKL 602

  Fly  1508 SMVGGDVNVRFKGTTQLKSIRPVHHMRAIPLGGVQHPSSTEPAVRVAPVPVELAPP 1563
            ......:.:..|   ||.|     ..|.:||...|.||.:    |..|:..:..||
Zfish   603 PSESRQLPLESK---QLPS-----ESRQLPLEFKQLPSES----RQLPLESKQLPP 646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	12/48 (25%)
		TBC	933..1152	CDD:214540	68/232 (29%)
		COG4372	<1190..>1353	CDD:443500	18/162 (11%)
tbc1d10aa	XP_009302447.1	TBC	102..304	CDD:214540	67/220 (30%)
		PHA03247	<426..869	CDD:223021	56/270 (21%)