Protein Alignment plx and Evi5

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_727526.2
• Gene: Evi5 / 32088
• FlyBaseID: FBgn0262740
• Length: 807
• Species: Drosophila melanogaster
• Alignment Length: 644
• Identity: 156/644 - (24%)
• Similarity: 275/644 - (42%)
• Gaps: 115/644 - (17%)

  Fly   830 DSEVPT---EFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRI 891
            :..:||   :.|:.:....|..:.||..|..|..|.       :|..::.:.:....:.|.:..
  Fly    28 EENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTH-------SRKNSDTSQISLTSSGNSVAE- 84

  Fly   892 KLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMN 956
                |:|......::..||..::|        |:|.| ...:|.|:|...|..||     |....
  Fly    85 ----EDIWTTWATILNDWEGALKR--------KNPCV-SELVRRGIPHHFRAIVW-----QQLSG 131

  Fly   957 TAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSIL 1021
            .:..|.|::..:       :|..:..:..|..|:.||:|..:|:|:..|.||.:|||::||||:.
  Fly   132 ASDGDKKQYAEY-------IKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLH 189

  Fly  1022 DPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHL 1086
            |.|:|||||.|||.|:||:...|..:|.:|..:|.:..||..:.|.|.:..|.:|||..||::.:
  Fly   190 DREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQI 254

  Fly  1087 PDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQL 1151
            ||:::...|.....|:||:.|.||::::...:....|:.|:...|..:.|||.|:|||...|..|
  Fly   255 PDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTL 319

  Fly  1152 LAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIG-KQLAEYKVEYNVLQEEITTTNHHLEM 1215
            |..| .|.::.:.:..:|......:|....|.:|:.:. |::.:.:.||..|:::.......|..
  Fly   320 LCLD-MEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRR 383

  Fly  1216 LNRE----KTQNQHL--------------------EQQLQFA-QSSIAQLETTRSSQQAQITTLQ 1255
            |.||    |.:|:.|                    |::..:| |:.:.||..:......|:....
  Fly   384 LRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENAN 448

  Fly  1256 SQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQ------------------LDDLDRQR 1302
            .:|:.|.|.:|          |:|..::..|..:..:.:                  |::|.:.|
  Fly   449 EEVRGLSLRLQ----------ENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVR 503

  Fly  1303 RKPIFTERKIGKSVSVNSHLGFPLKVLEELTE-------RDELGSPQKQKKEKTPFFEQLRQQ-- 1358
            :....:|.:|....:....|....|.|.|.|.       :|||.:.:.::.|.:...:.|:|:
  Fly   504 QGLAESEDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQDELIASKLREAEASLSLKDLKQRVQ 568

  Fly  1359 ----QQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDK 1413
                |.|.:|....:|.:  |..:....|.|.:||.|.         .|..|..||..|
  Fly   569 ELSSQWQRQLAENQRSES--ERTTNAVDSTPKKLLTNF---------FDSSKSSEHTQK 616

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	10/51 (20%)
		TBC	933..1152	CDD:214540	74/218 (34%)
		COG4372	<1190..>1353	CDD:443500	38/212 (18%)
Evi5	NP_727526.2	TBC	113..320	CDD:214540	74/218 (34%)
		Smc	<358..>761	CDD:440809	55/280 (20%)