DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and Evi5

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	NP_727526.2	Gene:	Evi5 / 32088	FlyBaseID:	FBgn0262740	Length:	807	Species:	Drosophila melanogaster

Alignment Length:	644	Identity:	156/644 - (24%)
Similarity:	275/644 - (42%)	Gaps:	115/644 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   830 DSEVPT---EFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRI 891
            :..:||   :.|:.:....|..:.||..|..|..|.       :|..::.:.:....:.|.:..
  Fly    28 EENLPTSEMDLLAKLEAANKLIESDAKSLNSLHSTH-------SRKNSDTSQISLTSSGNSVAE- 84

  Fly   892 KLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMN 956
                |:|......::..||..::|        |:|.| ...:|.|:|...|..||     |....
  Fly    85 ----EDIWTTWATILNDWEGALKR--------KNPCV-SELVRRGIPHHFRAIVW-----QQLSG 131

  Fly   957 TAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSIL 1021
            .:..|.|::..:       :|..:..:..|..|:.||:|..:|:|:..|.||.:|||::||||:.
  Fly   132 ASDGDKKQYAEY-------IKATSACEKVIRRDIARTYPEVEFFKEKDGPGQEALFNVIKAYSLH 189

  Fly  1022 DPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHL 1086
            |.|:|||||.|||.|:||:...|..:|.:|..:|.:..||..:.|.|.:..|.:|||..||::.:
  Fly   190 DREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQI 254

  Fly  1087 PDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQL 1151
            ||:::...|.....|:||:.|.||::::...:....|:.|:...|..:.|||.|:|||...|..|
  Fly   255 PDMHIHFQQQGFQTTMYASSWFLTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTL 319

  Fly  1152 LAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIG-KQLAEYKVEYNVLQEEITTTNHHLEM 1215
            |..| .|.::.:.:..:|......:|....|.:|:.:. |::.:.:.||..|:::.......|..
  Fly   320 LCLD-MEAMLKFFQKELPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRR 383

  Fly  1216 LNRE----KTQNQHL--------------------EQQLQFA-QSSIAQLETTRSSQQAQITTLQ 1255
            |.||    |.:|:.|                    |::..:| |:.:.||..:......|:....
  Fly   384 LRRENCLLKQRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENAN 448

  Fly  1256 SQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQ------------------LDDLDRQR 1302
            .:|:.|.|.:|          |:|..::..|..:..:.:                  |::|.:.|
  Fly   449 EEVRGLSLRLQ----------ENNVSIDSNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVR 503

  Fly  1303 RKPIFTERKIGKSVSVNSHLGFPLKVLEELTE-------RDELGSPQKQKKEKTPFFEQLRQQ-- 1358
            :....:|.:|....:....|....|.|.|.|.       :|||.:.:.::.|.:...:.|:|:
  Fly   504 QGLAESEDQIRNLKAKVEELEEDKKTLRETTPDNSVAHLQDELIASKLREAEASLSLKDLKQRVQ 568

  Fly  1359 ----QQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDK 1413
                |.|.:|....:|.:  |..:....|.|.:||.|.         .|..|..||..|
  Fly   569 ELSSQWQRQLAENQRSES--ERTTNAVDSTPKKLLTNF---------FDSSKSSEHTQK 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	9/47 (19%)
		TBC	933..1152	CDD:214540	74/218 (34%)
		RILP-like	<1176..1267	CDD:304877	23/116 (20%)
Evi5	NP_727526.2	TBC	113..320	CDD:214540	74/218 (34%)
Evi5	NP_727526.2	DUF4527	627..>731	CDD:291689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456556
Domainoid	1	1.000	109	1.000	Domainoid score	I1618
eggNOG	1	0.900	-	-		E1_KOG4436
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47026
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R541
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.870