DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and tbc

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	NP_001285494.1	Gene:	tbc / 318059	FlyBaseID:	FBgn0052506	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	1336	Identity:	234/1336 - (17%)
Similarity:	440/1336 - (32%)	Gaps:	393/1336 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ESYTKLSVGIENGILESYNSDFELQFSHPL-KHIVGMCR------IIHK-----PQAKSIGNGFL 88
            |:.||..|..|:..:.|.....|...|..| :..:|:.:      ::||     |:|:.|.....
  Fly    29 EAVTKKYVHEESSSVTSLCGAVEACLSQGLRRRALGLFKTSSTTALLHKIAKSCPEAEHISKLVQ 93

  Fly    89 QLKSSAG-----------------QTSSSSAVASSMGGAASSSLTGNGLRHTLTASTSYGSLSSS 136
            ::::|..                 :.|||:::::....|||:|.....:  :::||||..||:|.
  Fly    94 EIEASDPSKRSSSSSDSFQRPPMLKKSSSNSMSTGTNAAASTSSASASI--SVSASTSSMSLASM 156

  Fly   137 -----AACAYQLQLQQSAEASAEQPQNFMEFQGPITGLVYLLKDPKDPLLHIYLFECEAVEEMAE 196
                 ....|:.:|.:..|.......:|.:               :|.|:
  Fly   157 KYLWIRLALYEKRLTKIIEYLVSNASSFYD---------------RDSLV--------------- 191

  Fly   197 LMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATNL-------------KMS 248
                       .....|||..:|:.|        ..||....|..|.:.             ::|
  Fly   192 -----------ADSDYGSILSSLLVG--------PCALEFTRAKTADHYWTDPHADELVQRHRIS 237

  Fly   249 EAMRNAQHDTSPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLAD-ISPNHTHFFEV 312
            ...|::...:.|..::.|...:.|     |..:||.:..:..||    |:..| :...|.:....
  Fly   238 SCRRSSSTCSRPAIINFKRSLNTS-----SDEAGTGSFKSIASA----SVAKDYVESLHQNAKAT 293

  Fly   313 MYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLK 377
            :..||..|           ..|||..|........|.....:|:      |:..|:..:..:...
  Fly   294 LLYGKNNV-----------QVLPKDVAEPMPGYLSLHQHIQTLT------IKWTPNQLMNGYTEA 341

  Fly   378 EEDEEEQE---------------------QHKGHDD-------SQDSQAKPLV--------QLQL 406
            ||.|:..:                     |.:|.|.       .||...:|.:        |..|
  Fly   342 EEAEDIDKDAFWAYALNINVDEIVYVHCHQSRGEDSGGTVILVGQDGVQRPPIHFPEGGHMQQFL 406

  Fly   407 TGAEEGAAPRPLEDNKENKSPEKRPL--LRGQSQIELGHKEHSDGSQPLAANSQLEAP----NVI 465
            :..|.|..|....|         .||  .||..::.|..:.......|....|..|.|    ..|
  Fly   407 SCLETGLLPHGQLD---------PPLWSQRGIGKMFLWPRSMRRRILPSVMESVDETPIDYVFRI 462

  Fly   466 VNK----------------QPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIPKQRDRSASQGCI 514
            |:|                :.||.|.|   ..:.|.:......:.:.::|..|.:......|
  Fly   463 VSKSRHEEFAATHSILDFVRSTPRRAQ---LSSCSTTGSSDCSNKSLSIDQFPMESPLILQQ--- 521

  Fly   515 PPYVEQNRTMVFLVGRCDLRLI-SPDRKQVLLYKDFKDVASC-------------VHG----QKS 561
               .:|.:..:.......:.:: |..|:|::....:..:|.|             |||    :..
  Fly   522 ---QQQQQQQLLQAQSTSIEMVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVHGRITPEMK 583

  Fly   562 LDHFGIICRE---LNNDG------------YIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQ 611
            .|..|:....   ||.:|            |.|.|.....:.|...::.  ..||.:..|.:|||
  Fly   584 ADEEGLTKERWQLLNVNGVLENATEFYRLVYFGGVQPELRQEVWPYLLG--HYAFGSTTEDRKKQ 646

  Fly   612 DTQIFSCEHCPMLWYHKLCTD---VEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKT--- 670
            |.   :|:|    :|....::   |:.:.:::.:....|.:..||.....       |:::|
  Fly   647 DE---TCKH----YYETTMSEWLAVDAIVQQREKEKTARAVAKLSSGSNS-------GNDRTVRA 697

  Fly   671 ----------------NSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFM 719
                            .|.:::...     |....:.:||:...:.|          :.|:.:.:
  Fly   698 ADLEAGGDLENEVFEDISDISDPGD-----LEFDEQQQQQQQQAECA----------VSGNHLTV 747

  Fly   720 K----AKRSLTN------SFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSN 774
            |    |.::.|:      ||:.|  .:|.::|..........|.|       ::|....:|....
  Fly   748 KPIPRAMKTSTDSGHVDESFNEL--DEPDEEDNKQKQQQDEKISE-------SESKLPDYRKLEE 803

  Fly   775 TVGASPS-SKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFL 838
            .:...|| |..||...::        ||  |.|......|..:::|:.....:..|......:.:
  Fly   804 QINQEPSCSASTASSYET--------VG--PGEVHQRPNSDTRSVLSPEYLSADDLQLPDDEDAV 858

  Fly   839 SPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDK 903
            .|...||      ||            .:::.:     |.:.....|...|..:.|  ::.|.::
  Fly   859 RPPPPPA------AA------------AVIITK-----ASVDITNWERSPKAAEGD--QMSPLEE 898

  Fly   904 QLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTF-LAEQHSMNTAPVDTKRFPN 967
            |..|.....:..::.|     .||     .....|.|..|.|::. |.||..:|.
  Fly   899 QAGESGGAGVNMDALQ-----QPK-----SACASPASSNGGVYSSELLEQFGLNL---------- 943

  Fly   968 FNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGL- 1031
                            |.|..|:.|...|:.::.:. .|.:|.  |::..|.....::||.||:
  Fly   944 ----------------HRIEKDVQRCDRNYWYFANE-NLDKLR--NVISTYVWEHLDVGYMQGMC 989

  Fly  1032 GFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQN 1096
            ..:..:|::..||:.|:.....||.|   ..:..|......:....:..|::....::|..:|.|
  Fly   990 DLVAPLLVIFDDESLSYSCFCKLMER---MIENFPSGGAMDMHFANMRSLIQILDSEMYDLMDSN 1051

  Fly  1097 -DVSPTLYAAPWILTVFSSQFPLGFVARVFDLLF----LESSDVIFKFAIALLSVHKQQLLAKDN 1156
             |.:...:...|.|..|..:.....|...:::::    :.|...:...|:|||..::..:|:  |
  Fly  1052 GDYTHFYFCYRWFLLDFKRELVYDDVFATWEVIWAAKHIASGHFVLFLALALLETYRDIILS--N 1114

  Fly  1157 FEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQL 1192
            ..:..|.:|......|....:.:::|..|:.:..|:
  Fly  1115 SMDFTDVIKFFNEMAERHNAQSVLQLARSLVLQLQM 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	66/391 (17%)
		DUF3350	835..880	CDD:288663	6/44 (14%)
		TBC	933..1152	CDD:214540	43/225 (19%)
		RILP-like	<1176..1267	CDD:304877	3/17 (18%)
tbc	NP_001285494.1	RUN	45..218	CDD:280855	39/223 (17%)
		PH_RUTBC	292..466	CDD:275431	37/199 (19%)
		TBC	923..1087	CDD:214540	38/195 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456549
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940