Protein Alignment plx and Tbc1d8b

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001388066.1
• Gene: Tbc1d8b / 315912
• RGDID: 1563084
• Length: 1118
• Species: Rattus norvegicus
• Alignment Length: 766
• Identity: 149/766 - (19%)
• Similarity: 257/766 - (33%)
• Gaps: 272/766 - (35%)

  Fly   659 IVWAKFCGSEKTNSP-VAE--------QNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGG 714
            |.|......|||:|. |||        :|.:..|.|          |:::|.....:..|..:
  Rat   200 ISWDAISKLEKTSSVIVAESIHVCSQGENHYFSMFL----------HINETYLLMEQLTNYAI-- 252

  Fly   715 STIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGAS 779
            ..:|.|      .:|||    .|..||                 ||  |....|...|::
  Rat   253 KRLFDK------ETFDN----DPVLDD-----------------PL--QITKRGLEYRAH----- 283

  Fly   780 PSSKPTAEQLKSPMMDIFIKVGNSPKE---AETHQ-GSW-----------------------RQA 817
                  :||.|:     |.::   |||   .|.|: ..|                       :..
  Rat   284 ------SEQFKA-----FFRL---PKEETLKEVHECFLWVPFSHFSTHGKMCISENYICFASQDG 334

  Fly   818 ILNSVVTPSKGL------DSEVPTEFLSPMRKPA------KRGKRDAAELRELWRTAIRQ----- 865
            .|.||:.|.:.:      |....:..:|...|.|      |..::..|:||...|.|..|
  Rat   335 NLCSVIIPLREVLAVDKTDDSSRSVIISIKGKTAFRFNEVKDFEQLVAKLRLKCRAASTQDDGST 399

  Fly   866 --------TIMLNRMETE--------------NAMLQARQNEN----ELKRIKLDYEEIVPCDKQ 904
                    |.:....|.:              .|::.....:|    :.|.:|         :|.
  Rat   400 EVAISSDSTGLSENFEEQPLTFPKECSKTVNTEALMTVFHPQNLENLDSKMLK---------EKM 455

  Fly   905 LIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWT--------------FLAE--QH 953
            ..:.|..:.......:...:..|.....:| |:|.:.||::|.              :.||  :.
  Rat   456 KEQSWNILFSECGRGVSMFRTKKTRDLVVR-GIPETLRGELWMLFSGAVNDMAANPGYYAEVVEQ 519

  Fly   954 SMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAY 1018
            |:.|:.:.|:....                     ||.|:.|.|..::...|:.  :|..:|.||
  Rat   520 SLGTSNLATEEIER---------------------DLRRSLPEHPAFQSDTGIS--ALRRVLTAY 561

  Fly  1019 SILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKY--------LPDMKKFQLQL 1075
            :..:|::||||.:..:..||||:..|..:|.||..:..|  |...|        |.|...|:
  Rat   562 AYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCER--MLPDYFNRRIIGALVDQAVFE--- 621

  Fly  1076 YQLSRLVKDHLPDLYVWLDQNDVSPTLYAA---PWILTVFSSQFPLGFVARVFDLLFLESSDVIF 1137
                .|::||||.    |..:....|.:::   .|.||:|.|..|:.....|.|..|.:....|.
  Rat   622 ----ELIRDHLPQ----LTDHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAIL 678

  Fly  1138 KFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVL 1202
            :..:|:|..:..:||                     ||.:.
  Rat   679 QLGLAILDYNLDKLL---------------------TCKDD------------------------ 698

  Fly  1203 QEEITTTNHHLE-MLNREKTQNQHLEQ--QLQFAQSSIAQLETT---RSSQQAQITTLQSQVQSL 1261
            .|.:|..|...: ::|::.....:::|  .:...:|:.|:::.|   |.|.:...:.....:.|:
  Rat   699 AEAVTALNRFFDNVINKDSPLPSNVQQGSNINDGKSNHAKVDITDLIRESNEKYGSIRYEDIHSM 763

  Fly  1262 E-----LTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKPIF 1307
            .     ..||||    .:..:.|....:..:|:..||:||:|....:|.:|
  Rat   764 RCRNRLYVIQTL----EETTKQNVLRVVSQDVKMSLQELDELYVIFKKELF 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	13/81 (16%)
		TBC	933..1152	CDD:214540	59/245 (24%)
		COG4372	<1190..>1353	CDD:443500	24/129 (19%)
Tbc1d8b	NP_001388066.1	PH-GRAM1_TBC1D8B	156..254	CDD:275419	15/65 (23%)
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	16/91 (18%)
		TBC	485..693	CDD:214540	59/244 (24%)