Protein Alignment plx and CG4041

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_572197.4
• Gene: CG4041 / 31422
• FlyBaseID: FBgn0029736
• Length: 819
• Species: Drosophila melanogaster
• Alignment Length: 731
• Identity: 149/731 - (20%)
• Similarity: 245/731 - (33%)
• Gaps: 204/731 - (27%)

  Fly   643 ALILRRIETLSDDEQEIVWAKFCGSEKTNSPVA--EQNQFLMMLLRAHCESRQQRHVHDTAENRS 705
            :|.|..:|.:...|   :|.|...|......:|  :.|..|..:.|.|       ..|:......
  Fly   179 SLALVMVELILQIE---LWPKLKLSNVVRKILAFGKSNGALEKIAREH-------QCHERYVQMD 233

  Fly   706 EFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFR 770
            :.|.|.|......:..:|.|...    |...|..:::      |.|:::...:||
  Fly   234 QRLRQLLESCLSVLPKRRPLPGE----LLEHPIFEEV------LLDLKKQKMQPL---------- 278

  Fly   771 SRSNTVGASPSSKPTAEQLKSPMMDIF----IKVGNSPKE------------------------A 807
                    ||.::.....|:.|:..|:    :..|:...|                        |
  Fly   279 --------SPETEHLPLLLRCPLSQIYHLWQLAGGDVQAELKKEGLIRSEAPILGLPQIVRLSGA 335

  Fly   808 ETHQGSWRQAILNSVVTPSK---------GLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAI 863
            ....|..:..:::..|.|.:         ||.:.|....|...|.||    ..|.||:||
  Fly   336 SVCPGRSQAQLMDDRVVPLRLKALLQRLSGLPAAVYFPLLHSPRFPA----HFARELQEL----- 391

  Fly   864 RQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKV 928
                        ..:::.:..|.:.:|::|        ..:|::.:....|:
  Fly   392 ------------PLVIREKDIEYQFQRVRL--------FARLLQGYPHTAEQ------------- 423

  Fly   929 LGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHL-TEHQHAIFIDLGR 992
            |.......||...||.:|..|.|     ..|         |..|..:.|.. |.....|.:|:.|
  Fly   424 LQREAAVDVPPLLRGPIWAALLE-----VVP---------NGSYAKIDKFTSTSTDRQIEVDIPR 474

  Fly   993 TFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLL---LHCDEANSFQLLKHL 1054
            .....:....|  .|...|..||||:....|:..|.|||..:....|   .:.:|.....|.|.:
  Fly   475 CHQYDELLSSP--DGHRKLRRLLKAWVTAHPQYVYWQGLDSLTAPFLYLNFNNEELAFLSLFKFI 537

  Fly  1055 MFRRNMRTKYLPD----MKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQ 1115
              .:.::..:|.|    :|::   |.:.|:|...|.|.|...|......|.|:|.||.||:||..
  Fly   538 --PKYLQWFFLKDNSAVIKEY---LSKFSQLTAFHEPLLAQHLASISFIPELFAIPWFLTMFSHV 597

  Fly  1116 FPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIM 1180
            |||..:..::|.|.|..|.......||:|...:..||. ..|.|               |:
  Fly   598 FPLHKILHLWDKLMLGDSSYPLFIGIAILRQLRSTLLT-SGFNE---------------CI---- 642

  Fly  1181 KLVFS------MDIGKQLAEYKVEYNVLQEEITTTNHHLEM-------LNREKTQNQHLEQQLQF 1232
             |:||      || |..|...|: |....:.||...|.|.:       :.....:.:||:|: |.
  Fly   643 -LLFSDLPDIVMD-GCVLESQKM-YEATPKSITHRQHALRLQPPQALDIGVADVELKHLQQE-QC 703

  Fly  1233 AQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNP-DLELP------NEVRR 1290
            .:.|...::....:..|::..:..:      ::...||.      |.| .:.:|      .|.|.
  Fly   704 PRISAKDVQFLLDNSPAELALIDLR------SVVEFGRV------HVPHSINIPFATVQLGEQRL 756

  Fly  1291 MLQQLDDLDRQRRKPI 1306
            ...|:..|:.|.|..|
  Fly   757 EALQVPQLEAQLRGKI 772

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	10/48 (21%)
		TBC	933..1152	CDD:214540	60/226 (27%)
		COG4372	<1190..>1353	CDD:443500	25/131 (19%)
CG4041	NP_572197.4	Protein Kinases, catalytic domain	48..263	CDD:473864	20/97 (21%)
		TBC	432..634	CDD:214540	60/222 (27%)
		RHOD_Kc	706..810	CDD:238783	14/79 (18%)