Protein Alignment plx and Tbc1d2

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_063143695.1
• Gene: Tbc1d2 / 313234
• RGDID: 1306860
• Length: 925
• Species: Rattus norvegicus
• Alignment Length: 933
• Identity: 184/933 - (19%)
• Similarity: 326/933 - (34%)
• Gaps: 292/933 - (31%)

  Fly   363 IEAKPSSSLKSHDLKEEDEEEQE---QHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKEN 424
            :.|.| |:|::..||....|.|.   ..:|:..:|.:...|                |:|::.::
  Rat   198 VPAMP-SALQNISLKHLGTEIQNTMYNIRGNKQAQATAHGP----------------PVEESSQS 245

  Fly   425 KSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASASAGP 489
            ..|::                   |.|||.::     |::...|:|..|
  Rat   246 AEPQR-------------------GEQPLISD-----PSIPAEKEPEDP---------------- 270

  Fly   490 SQLHPNYAMDNIPKQRDRSASQGCIP------PYVEQNRTMVFLVGRCDLR-----LISPDRKQV 543
                        ||    ||.:.|:|      |..:.|....|..|....|     :::.:::.:
  Rat   271 ------------PK----SAPRSCVPSGPMQKPKRQSNTFPFFSDGLARSRTAQEKVVALEQQVL 319

  Fly   544 LLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQK 608
            :|.|:.|       .||                               ::|..:.:|.:...::|
  Rat   320 MLTKELK-------SQK-------------------------------ELVIILHKALEAAQQEK 346

  Fly   609 KKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQ-ALILRRIETLSDDEQEIVWAKFCGSEKTNS 672
            :.....:.:.|....|         |.:..|..| |.:.:|:|.|..|.:.:|..  .|..:...
  Rat   347 RASSAYLAATEDRDRL---------ELVRHKVRQIAELNQRVEALEQDRERLVHE--AGLREQQV 400

  Fly   673 PVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKP 737
            ...:|:   :.||....:::||                      :..|..:.||
  Rat   401 QALQQH---VQLLMDKNQAKQQ----------------------VICKLSQKLT----------- 429

  Fly   738 SKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVGN 802
              :|:|.|                  .|.:.      |.|...|.:...|.||..|.  ..:..|
  Rat   430 --EDLAQP------------------QPADA------TNGDFLSQQERLEHLKDDME--AYRTQN 466

  Fly   803 SPKEAETHQGS--WRQAILNSVVTPSKGL----------DSEVPTEFLSPMRKPAKRGKRDAAEL 855
            ....:|.||.:  ||:     |....|.|          :.:|.:::|:.:|:..:....:..:.
  Rat   467 RFLNSEIHQVTKIWRK-----VAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEAAGAEPGDF 526

  Fly   856 RELWRTAIRQTIM-------------------------LNRMETENAMLQARQNENELKRIKLDY 895
            .||.:..:::.:.                         :...|.|:..|.|:....|::...|..
  Rat   527 PELLQQLVQEALQWEAGEASDSVGLSPVSEYDDYGFLTVPDYEVEDLKLLAKIQALEVRSHHLLA 591

  Fly   896 EEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQ-----HSM 955
            .|.|  ::.|.:||..:     |::....:.|.|   :|.||||..|..||.:|..:     ||.
  Rat   592 LEAV--ERPLRDRWATL-----TELMPSAELKQL---LRAGVPREHRPRVWRWLVHRRVQHLHSS 646

  Fly   956 NTAPVDTKRFPNFNTPYHMLLK--HLTEHQHA--IFIDLGRTFPNHQFYKDPLGLGQLSLFNLLK 1016
            ..              |..||.  ...||..|  |.:||.||||.::.:..|.......|..:|.
  Rat   647 GC--------------YQELLARGRACEHPAARQIELDLNRTFPTNKHFTCPTSSFPDKLRRVLL 697

  Fly  1017 AYSILDPELGYCQGLGFICGVLLLHC-DEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSR 1080
            |:|..:|.:||||||..:..:.||.. ||.::|..|..::........|...:...|:....|..
  Rat   698 AFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETILPAEYYSKTLTASQVDQRVLQD 762

  Fly  1081 LVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLS 1145
            |:.:.||.|...|.|..|..:|....|.|.:|:.......:.||:|....|.:.|:|::|:|:..
  Rat   763 LLSEKLPRLTAHLGQRHVDLSLITFNWFLVIFADSLISDILLRVWDAFLYEGTKVVFRYALAIFK 827

  Fly  1146 VHKQQLLAKDNFEEIMDYL----KTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEI 1206
            .:::.:|...:..||..||    ||:....:.|.:.......|.|   |||.:.:..:   :|.:
  Rat   828 YNEEAILRLQDSLEIYQYLRFFTKTICDSRKLTSIAFNDMNPFPM---KQLRQLRAAH---RERL 886

  Fly  1207 TTTNHHLEMLNREKTQNQHLEQQ 1229
            ......||:|..|     :||::
  Rat   887 EAELRELELLKAE-----YLERR 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	39/251 (16%)
		DUF3350	831..880	CDD:463365	7/73 (10%)
		TBC	933..1152	CDD:214540	64/228 (28%)
		COG4372	<1190..>1353	CDD:443500	10/40 (25%)
Tbc1d2	XP_063143695.1	None