DRSC/TRiP Functional Genomics Resources

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Protein Alignment plx and Tbc1d4

DIOPT Version :9

Sequence 1:NP_001163511.1 Gene:plx / 40704 FlyBaseID:FBgn0261261 Length:1572 Species:Drosophila melanogaster
Sequence 2:XP_038949896.1 Gene:Tbc1d4 / 306117 RGDID:1561609 Length:1300 Species:Rattus norvegicus


Alignment Length:1301 Identity:416/1301 - (31%)
Similarity:615/1301 - (47%) Gaps:318/1301 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 MAELMHQMRDPAHTLGGSVGS-----------------IPQTLIGGGGGSHGNSNGALNGIHATP 241
            |||:..:...|.   .|..|:                 :|...:|.|||:   .:||:.     |
  Rat    59 MAEIRRRSLKPE---AGGCGAPAAREVLLVLSAPFLRCVPAPGVGVGGGA---GSGAVQ-----P 112

  Fly   242 ATNLKMSEAMRNAQH------------------DTSPNPVSSKMKASKSYTHGLSSSSGTVNIPT 288
            .|.:.:.|  ..|||                  ...|:...|:|..   :....:..:...::.:
  Rat   113 NTGVFIFE--HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMAC---HVFRATDPNQVPDVIS 172

  Fly   289 STSAQSNLSLLADISPN--------HTHFFEVMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQRL 345
            |....|..::..|..|:        ::..|||:|.|::.|:.|:.|::.|||...||..::.|||
  Rat   173 SIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGRVIVTHKKAPSSLIDDCKDKFSLHEQQRL 237

  Fly   346 RLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLKEEDEE---EQEQHKGHDDSQDSQAKPLVQLQLT 407
            :|...|       ||              |..:.||.   |.|.....||....:...||.    
  Rat   238 KLQGER-------GG--------------DPGDGDEMGVLEAESPVSPDDGLPEKPDGLVN---- 277

  Fly   408 GAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIV------ 466
                  .||.|      .|....|.|               .|||..|:|::..|..|:      
  Rat   278 ------CPRAL------PSLASLPAL---------------ASQPALASSRVCFPERILEDCGFD 315

  Fly   467 NKQPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRC 531
            .:|....|...| ||...     .::|.|..... |::|..||.....|...|:||||:|.|||.
  Rat   316 EQQEFRSRCSSV-TGVMQ-----KKVHENNQKTQ-PRRRHASAPSHVQPSDSEKNRTMLFQVGRF 373

  Fly   532 DLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDG---YIGYVFKCQSEHVCDDI 593
            ::.|||||.|.|:|.|:|||::||..|.|.:||||.||||....|   ||.|||:|.:|.:.|::
  Rat   374 EINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESLEPGLSQYICYVFQCANESLVDEV 438

  Fly   594 VAAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQE 658
            :..:.|||.|.|..:..: |||..||.|||...||||..:|||...:.:.:|.|.:.:|:|:||.
  Rat   439 MLTLKQAFSTAAALQSAK-TQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQA 502

  Fly   659 IVWAKFCGSEKTNSPVA--EQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYL------GG- 714
            .::.:.    :...|::  |:|:.:::.||..||::|:.||| ..|.::...|..:      || 
  Rat   503 DIFERV----QKMKPISDQEENELVILHLRQLCEAKQKTHVH-IGEGQAIISNSTIPENSTSGGR 562

  Fly   715 ---STIFMKAKRSLTNSFDNLLKRKPSK-------DDIAVPSHNL---RDIREGSAEPLGTQSPP 766
               ..:..|||||||:|.:|:..|..::       .|....|::|   :|...|.:.| ||  ||
  Rat   563 FKLDVLKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDFSPGGSPP-GT--PP 624

  Fly   767 EG------------------FRSRSNTVGASPSSK--------PTAEQLKSPMM----------- 794
            ..                  ||.|::|....|||.        ..|..|:||::           
  Rat   625 ASPLSSAWHTFPEEDSDSPQFRRRAHTFSHPPSSSRRKLNLQDGKAHGLRSPLLRQNSSEQCSVL 689

  Fly   795 ------------------------------DIFIK-----VGN-SPK-EAETHQG---------- 812
                                          ..|:|     .|. ||: |.|...|          
  Rat   690 PSARRMCKESNSSSSLPSLHTSFSAPSFTASSFLKSFYQSSGRLSPQYENEISDGEGRKRTSSTC 754

  Fly   813 -----------------SWRQAILNSVVTP-----------SKGLDSE--VPTEFLSPMRKPAK- 846
                             ||||.|...|.:|           ..|||..  :|...|||..:... 
  Rat   755 SNESLSAGGTPVTPRRISWRQRIFLRVASPVNKSPSAMQQQKDGLDRTELLPLSPLSPTMEEEPL 819

  Fly   847 -------------RGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEI 898
                         ..|:.:.|::.||:.||.|.|:|.|||.||..|:||::|.:.:::||||||:
  Rat   820 VIFLSGDEDTEKVEEKKKSKEIKSLWKKAIHQQILLLRMEKENQKLEARRDELQSRKVKLDYEEV 884

  Fly   899 VPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTK 963
            ..|.|:::..|::.:....|:|  :.|.:.:..:::.|||:|:||::|.|||.|:.:.      .
  Rat   885 GTCQKEVLIAWDKKLLNCRTKI--RCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRLR------H 941

  Fly   964 RFPNFNTP----YHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPE 1024
            |.||.:.|    |..|||.||..||||.:|||||||...::...||.|||||||||||||:||.|
  Rat   942 RLPNKHQPPDTSYKELLKQLTAQQHAILVDLGRTFPTQPYFSVQLGAGQLSLFNLLKAYSLLDKE 1006

  Fly  1025 LGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDL 1089
            :|||||:.|:.||||||..|..:|::||.||:....|.:|.|||...|:|:||||||:.|:..||
  Rat  1007 VGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDL 1071

  Fly  1090 YVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAK 1154
            |..|::|::||:||||||.||:|:|||||||||||||::||:.::||||.|::|||..:..::..
  Rat  1072 YNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSSQEALVMEC 1136

  Fly  1155 DNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTT------NHHL 1213
            :|||.|:::||:.:|.|..|.||:|:..||.|||.|||..|:|||:|||:|:..:      |..|
  Rat  1137 ENFENIVEFLKSTLPDMNTTEMEKIITQVFEMDISKQLHAYEVEYHVLQDELLESSYACEDNESL 1201

  Fly  1214 EML----NREKTQNQHLEQQLQFAQSSIAQLE-------TTRSSQQAQITTLQSQVQSLELTIQT 1267
            |.|    |:.|.||..|.::||.|.:.|..||       |..:..:|.|.||:....:.:.|::.
  Rat  1202 EKLERANNQLKRQNMDLLEKLQVAHAKIQALESNLETLLTRETKMKALIRTLEQDKMAYQKTVEQ 1266

  Fly  1268 L 1268
            :
  Rat  1267 I 1267

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plxNP_001163511.1 PTB_TBC1D1_like 301..601 CDD:269967 99/319 (31%)
DUF3350 835..880 CDD:288663 17/58 (29%)
TBC 933..1152 CDD:214540 121/222 (55%)
RILP-like <1176..1267 CDD:304877 40/107 (37%)
Tbc1d4XP_038949896.1 PTB 31..190 CDD:214675 26/146 (18%)
PTB_TBC1D1_like 193..446 CDD:269967 97/311 (31%)
DUF3350 803..866 CDD:403130 18/62 (29%)
TBC 920..1130 CDD:214540 121/215 (56%)
PTZ00440 <1134..>1265 CDD:240419 49/130 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 248 1.000 Domainoid score I2070
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 570 1.000 Inparanoid score I1023
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D164786at33208
OrthoFinder 1 1.000 - - FOG0003414
OrthoInspector 1 1.000 - - otm44596
orthoMCL 1 0.900 - - OOG6_105859
Panther 1 1.100 - - O PTHR22957
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2765
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1110.970

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