Protein Alignment plx and Rabgap1l

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_063128419.1
• Gene: Rabgap1l / 304914
• RGDID: 1304620
• Length: 1066
• Species: Rattus norvegicus
• Alignment Length: 1224
• Identity: 253/1224 - (20%)
• Similarity: 469/1224 - (38%)
• Gaps: 302/1224 - (24%)

  Fly   363 IEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAE--EGAAPRPLEDNKENK 425
            :...|.|:.   .|..|:.....||. .|.|.....||.:::...|.|  |.|....|.|:::.:
  Rat    25 VSGSPDSAA---TLNSEEFVLVPQHT-DDTSIKDDGKPQLKIASNGDEQLEKAMEEILRDSEKGQ 85

  Fly   426 SPEKRPLLRGQSQIELGHKEHSDGSQPLA-------------ANSQLEAP------------NVI 465
            |  ..| :.||...|:  .:||.|..|.:             :|:::..|            :|:
  Rat    86 S--SLP-VDGQGSSEI--SDHSFGDVPASQSNKPPLQLILDPSNTEISTPRPSSPSGFPEEDSVL 145

  Fly   466 VNK-------QPTPPRDQGVGTGTASASAGPSQLHP---NYAMDNIPKQRDRSASQGCIPPYVEQ 520
            .||       :.:.||.:|... .|.|:...|..:|   ...:.|:|:...|         .::|
  Rat   146 FNKLTYLGCMKVSSPRSEGEAL-RAMATMRASSQYPFAVTLYVPNVPEGSVR---------IIDQ 200

  Fly   521 NRTMVFLVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQ 585
            :..:                 ::..:..:| |..|..|               :||        .
  Rat   201 SSNV-----------------EIASFPIYK-VLFCARG---------------HDG--------T 224

  Fly   586 SEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCE--HCPMLWYHKLCTDVEGLSEKKTQALILRR 648
            :|..|        .||...:...::....:||||  .......:..||..:            |.
  Rat   225 TESNC--------FAFTESSHGSEEFQIHVFSCEIKEAVSRILYSFCTAFK------------RS 269

  Fly   649 IETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLG 713
            ...:||.:..|:            |..:.:.|...:.....|...:.:.....::|.:|
  Rat   270 SRQVSDVKDSII------------PTPDSDVFTFSVSLEVKEDDGKGNFSPVPKDRDKF------ 316

  Fly   714 GSTIFMKAKRSLTNSFDNLLKRKPSKDDIAV---------PSHNLRDIREGSAEPLGTQSPPEGF 769
                :.|.|:.:.......:::..:| ::|:         |.   |:::......|..:|..:.:
  Rat   317 ----YFKIKQGIEKKVVITVQQLSNK-ELAIERCFGMLLSPG---RNVKNSDMHLLDMESMGKSY 373

  Fly   770 RSRSNTVGASPSSKPTAEQLKSPMMDIFIKVG-NSPKEAETHQGSWRQAILNSVVTPSKGLDSEV 833
            ..|:..:..          :.:|...||:.:. .:||:...:.......::..||.|.:.|...|
  Rat   374 DGRAYVITG----------MWNPNAPIFLALNEETPKDKRVYMTVAVDMVVTEVVEPVRFLLETV 428

  Fly   834 P-----------------TE-FLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAML- 879
            .                 || |...:::...:|...|.:       ||.:.:.|.|...:...:
  Rat   429 VRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGD-------AIYEVVSLQRESDKEEPVT 486

  Fly   880 --------------QARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLG 930
                          ...:::|||.....|..:  .|.::::..|.:::.|....:..:  ||.|.
  Rat   487 PTSGGGPASPQEDEAEEESDNELSSGTGDVSK--DCPEKILYSWGELLGRWHNNLNAR--PKGLP 547

  Fly   931 HAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFP 995
            ..:::|||.:.|.:||..||..|. |.|.:|         .|.:|:...:..:..|..|:.||||
  Rat   548 TLVKSGVPEALRAEVWQLLAGCHD-NQAMLD---------KYRILITKDSAQESVITRDIHRTFP 602

  Fly   996 NHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNM 1060
            .|.::||..|.||.||:.:.||||:.|.::|||||..|:..|||||..|..:|.:|.::|::..:
  Rat   603 AHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFCVLVNIMYKYKL 667

  Fly  1061 RTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVF 1125
            |..|..:.:....:.|||.:|:::.|||||......::...:||:.|.||:|:::|||..|..:.
  Rat   668 RDLYKNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAHMYASQWFLTLFTAKFPLCMVFHII 732

  Fly  1126 DLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPK-----------MEHTCMEQI 1179
            |||..|..::||..|:|||...|:.||..| ||..:.:.:..:||           ||..|..::
  Rat   733 DLLLCEGLNIIFHVALALLKTSKEDLLQAD-FEGALKFFRVQLPKRYRAEENARRLMEQACNIKV 796

  Fly  1180 MKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIA-QLETT 1243
            ..        |:|.:|:.||..::|........::...||..:.|....:|:.....:| :|.|:
  Rat   797 PT--------KKLKKYEKEYQAMRENQLQQEDPMDRYKRENRRLQEASMRLEQENDDLAHELVTS 853

  Fly  1244 RSSQQAQITTLQ--SQVQSLEL--TIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRK 1304
            :.:.:..:...:  :.|.|.||  |.|.|             :|...|.|:..::...|....||
  Rat   854 KIALRNDLDQAEDKADVLSKELLFTKQRL-------------VETEEEKRKQEEETAQLKEVFRK 905

  Fly  1305 PI-FTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGG 1368
            .: ..|.:|.|:.::             :.|..::.|....:.||    :|...:::...:.|..
  Rat   906 QLEKAEYEIKKTTAI-------------IAEYKQICSQLSTRLEK----QQAASKEELEAVKGKM 953

  Fly  1369 QS--------SNVGESGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDKFVANIKSPL--- 1422
            .:        |..| :|.|...||.::.|:....:..::.:|.|::|.      :|..|..|
  Rat   954 MACKHCSDIFSKEG-AGKPVAISREDQGLEADDEKDSLKKQLREMELE------LAQTKLQLVEA 1011

  Fly  1423 -----EVDSGVGTPLSPPSTASNS----SGGSIFSRMGYRTTPPALSPLAQRQS 1467
                 |::...|..::....|.||    :..||.:..|.:...|..:|...::|
  Rat  1012 KCKIQELEHQRGALMNEIQAAKNSWFSKTLNSIKTATGTQPLQPPQAPQPPKES 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	49/274 (18%)
		DUF3350	831..880	CDD:463365	10/81 (12%)
		TBC	933..1152	CDD:214540	80/218 (37%)
		COG4372	<1190..>1353	CDD:443500	33/168 (20%)
Rabgap1l	XP_063128419.1	None