Protein Alignment plx and Tbc1d9

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001402001.1
• Gene: Tbc1d9 / 304645
• RGDID: 1308221
• Length: 1262
• Species: Rattus norvegicus
• Alignment Length: 1198
• Identity: 237/1198 - (19%)
• Similarity: 392/1198 - (32%)
• Gaps: 437/1198 - (36%)

  Fly   526 FLVGRCDLRLI-------SPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFK 583
            ||:|| :.:|:       ..::...||..|...|::     :|.:||..:...:|.      .||
  Rat   191 FLMGR-EAKLVIRWVDITQLEKNATLLLPDMIKVST-----RSSEHFFSVFLNINE------TFK 243

  Fly   584 CQSEHVCDDIVAAIA-------QAFD---TCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSE 638
            ...:      :|.||       :.|:   :..:.|||...::.:.         |...|....||
  Rat   244 LMEQ------LANIAMRQLLDNEGFEQDRSLPKLKKKSPKKVSAL---------KRDLDARAKSE 293

  Fly   639 KKTQALILRRIETLSDDEQEIVWAKF----------------CGSEKTN---------------- 671
            :......|.:.|.|.......:|..|                |.:.|..
  Rat   294 RYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVE 358

  Fly   672 ---------SPVAEQNQFLMMLLRAHCESRQQRHVHDTAENR-SEFLNQYLGGSTIFMKAKRSLT 726
                     ||::...:..|..|.|:.:.|      |....| |:||.|..  |.|:.:...|..
  Rat   359 KADSCSVLPSPLSISTRNRMTFLFANLKDR------DFLVQRISDFLQQTT--SRIYSEFSGSCN 415

  Fly   727 NSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEG---FRSRSNTVGASPSSKPTAEQ 788
            :|.|.:..|         ||..:     .|:....|.|..:|   |....|:|       |||.|
  Rat   416 SSDDEVYSR---------PSSLV-----SSSPQRSTSSDADGERPFNLNGNSV-------PTATQ 459

  Fly   789 LKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAA 853
               .:|.::.:  .||:|                      .:.::..|||.
  Rat   460 ---TLMTMYRR--RSPEE----------------------FNPKLAKEFLK-------------- 483

  Fly   854 ELRELWR---TAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIER 915
              .:.|:   ....|.|.:.|.|        :..|..||
  Rat   484 --EQAWKIHFAEYGQGICMYRTE--------KTRELVLK-------------------------- 512

  Fly   916 NSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLL-KHL 979
                                |:|...||::|..|:  .::|    :....|.:   |..|: |.:
  Rat   513 --------------------GIPERMRGELWLLLS--GAIN----EKATHPGY---YEDLVEKSM 548

  Fly   980 TEHQHA---IFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLH 1041
            .::..|   |..||.|:.|.|..:::.:|:.  :|..:|.||:..:|.:||||.:..:..||||:
  Rat   549 GKYNLATEEIERDLHRSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLY 611

  Fly  1042 CDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLV-------------KDHLPDLYVWL 1093
            ..|..:|.||..|..|      .|||        |..:|:|             :|::|.||..:
  Rat   612 AKEEEAFWLLVALCER------MLPD--------YYNTRVVGALVDQGVFEELARDYVPQLYDCM 662

  Fly  1094 DQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL-AKDNF 1157
            ....|..|: :..|.||:|.|..|......|.|..|.|...|||:.|:|:|..:..:|| .||:.
  Rat   663 QDLGVISTI-SLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLGCKDDG 726

  Fly  1158 EEIM---DYLKTV------VPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHL 1213
            |.:.   .||.:|      :|.:.|      :..:.|.|:|...|   |:...|   |.|:....
  Rat   727 EAMTVLGRYLDSVTNKDSTLPPIPH------LHSLLSDDVGPYPA---VDIFRL---IGTSYEKF 779

  Fly  1214 EMLNREKTQNQHLEQQLQFAQSSIAQLE--TTRSSQQAQITTLQSQVQSLE----------LTIQ 1266
            ..:..:..:....:|:|:..|:    ||  |.|:..:..:|.....:..||          ||..
  Rat   780 GTIRADLIEQMRFKQRLKVIQT----LEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLTSC 840

  Fly  1267 TLGRYVGQLVEHNPDLELPNEVR---------------------------RMLQQLDDLDRQRRK 1304
            ..|........|:|.|....:.|                           |:.|.||:.......
  Rat   841 YWGGSSNAPDRHDPSLPYLEQYRIDFEQFKGMFVLLFPWACGTHSDVLASRLFQLLDENGDSLIN 905

  Fly  1305 PIFTERKIGKSVSVNSHLGFPLKVL-------EELTERDE------------------------L 1338
              |.|...|.|.:.:..|...||:|       |...::||                        |
  Rat   906 --FREFVSGLSAACHGDLTEKLKLLYKMHVLPEPSCDQDEPDSAFEATQYFFEDITPECTHVVGL 968

  Fly  1339 GSPQKQKKEKTPFFEQLRQ--------QQQQHRLN-GGGQSSNVGESGSPTP------------- 1381
            .|..||..::......|:|        |:.:|.|. ...::.:..::....|
  Rat   969 DSRGKQSADEGFVTVSLKQDRGKRANSQENRHYLKLWTAENKSKSKNAKDLPKLNQGQFIELCKT 1033

  Fly  1382 -----PSRPN--RLLDNASARTVMQVKLDELKLPEHVDKFVANIKSPLEVDSGVGTPLSPPSTAS 1439
                 ...||  .|....:|.|.:.:::.|      |.||.  |..|.:.|:..|.|      .|
  Rat  1034 MYNMFSEDPNEQELYHATAAVTSLLLEIGE------VGKFF--ITQPAKEDAVPGPP------CS 1084

  Fly  1440 NSSGGSIFSRMGYRTTPPALSPLAQRQSYGVAITTAPCP--------QH----------MEEVAP 1486
            .:..|.:|.:.|            ..||| |..:|.|.|        :|          :|:.:|
  Rat  1085 QAIPGMLFPKKG------------SSQSY-VVESTDPLPASLAGDREEHSLGGQMEDIKLEDSSP 1136

  Fly  1487 ----ATTMAVMPQEDVEEPQPMHPLSMV 1510
                |.:..::..:|.::...|...|::
  Rat  1137 RDNGACSSMLISDDDTKDDSSMSSYSVL 1164

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	18/88 (20%)
		DUF3350	831..880	CDD:463365	8/51 (16%)
		TBC	933..1152	CDD:214540	66/235 (28%)
		COG4372	<1190..>1353	CDD:443500	41/232 (18%)
Tbc1d9	NP_001402001.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	18/81 (22%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	15/100 (15%)
		TBC	510..720	CDD:214540	68/281 (24%)
		EFh	<891..921	CDD:415501	8/31 (26%)
		RRM_SF	944..1008	CDD:473069	9/63 (14%)