Protein Alignment plx and Evi5l

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001418968.1
• Gene: Evi5l / 304201
• RGDID: 1561962
• Length: 815
• Species: Rattus norvegicus
• Alignment Length: 599
• Identity: 152/599 - (25%)
• Similarity: 262/599 - (43%)
• Gaps: 91/599 - (15%)

  Fly   819 LNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQA-- 881
            |:::.:|:...||.......:|...|....:..:.:..||          |.::|.:|.:|:|
  Rat     3 LSTMASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELEL----------LAKLEEQNRLLEADS 57

  Fly   882 ----------RQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTG 936
                      |.:.:.|.........:...::.....|.:|  .|..:...::..|:|...||.|
  Rat    58 KSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRI--ANEWEEWRRRKEKLLKELIRKG 120

  Fly   937 VPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYK 1001
            :|...|..||..|.....|   ||..:        |..|||..:..:..|..|:.||:|.|:|:|
  Rat   121 IPHHFRAIVWQLLCSATDM---PVKNQ--------YSELLKMSSPCEKLIRRDIARTYPEHEFFK 174

  Fly  1002 DPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLP 1066
            ....|||..|||::||||::|.|:|||||..||.|:||:...|..:|.:...||....:|..:.|
  Rat   175 GQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKP 239

  Fly  1067 DMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLE 1131
            .|.:..|.:||...::::.||||...........::||:.|.||:|.:.|||....||||:...|
  Rat   240 SMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYE 304

  Fly  1132 SSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYK 1196
            ..:::|:..:|||.|::.:|:..| .|.:..|.:.|:|....:|.::::           |..|:
  Rat   305 GLEIVFRVGLALLQVNQTELMQLD-MEGMSQYFQRVIPHQFDSCPDKLV-----------LKAYQ 357

  Fly  1197 VEYNV-----LQEEITTTNHHLEM-----LNREKTQNQHLEQQLQFAQSSIAQL-------ETTR 1244
            |:||.     |::|....... ||     :.|.:|:|:.|:|:::..:...|.|       :.||
  Rat   358 VKYNPKKMKRLEKEYAAMKSK-EMEEQIEIKRLRTENRLLKQRIETLEKESAALADRLIQGQVTR 421

  Fly  1245 SSQ-------QAQITTLQSQVQSLELTIQTLGRYVGQLVE--HNPDL----------ELPNEVRR 1290
            :.:       :.::..::.|..|....:|.....:.||.|  .||.|          ||.....|
  Rat   422 AQEAEENYVIKRELAVVRQQCSSTAEDLQKAQSTIRQLQEQQENPRLTEDFVSHLETELEQSRLR 486

  Fly  1291 MLQQLDDLDRQRRKPIFTERKIGKSVSVN--SHLGFPLKVLEELTERDELGSPQKQKKEKTPFFE 1353
            ..:.|..|...:.|.:..|::.......|  :.|...||.| ::.|.:.:.|.::.|.:    .:
  Rat   487 ETETLGALREMQDKVLDMEKRNSSLPDENNVARLQEELKAL-KVREGEAVASARELKLQ----LQ 546

  Fly  1354 QLRQQQQQHRLNGG 1367
            :|....|.|...||
  Rat   547 ELSDTWQAHVSRGG 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	8/48 (17%)
		TBC	933..1152	CDD:214540	78/218 (36%)
		COG4372	<1190..>1353	CDD:443500	42/200 (21%)
Evi5l	NP_001418968.1	TBC	117..325	CDD:214540	78/218 (36%)
		SMC_prok_B	<381..719	CDD:274008	38/185 (21%)