Protein Alignment plx and Rabgap1l

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_006496938.1
• Gene: Rabgap1l / 29809
• MGIID: 1352507
• Length: 1051
• Species: Mus musculus
• Alignment Length: 1247
• Identity: 249/1247 - (19%)
• Similarity: 465/1247 - (37%)
• Gaps: 319/1247 - (25%)

  Fly   318 IRVSQKRVPNTFIDDALPKFKAY---DAQRLRLLQN-RKMSLSSEGGVGIEAKPSSSLKSHDLKE 378
            :.|||.....:..||..|:.|..   |.|..:.::. .:.|...:.|:.::.:.||.:.....
Mouse    26 VLVSQHTDATSIKDDGKPQLKIASNGDEQLEKAMEEILRDSEKGQSGLPVDCQGSSEISDCPF-- 88

  Fly   379 EDEEEQEQHKGHDDSQDSQ-AKPLVQLQLTGAE-EGAAPRPLEDNKENKSPEKRPLLRGQSQIEL 441
                        .|...|| .||.:||.|..:. |.:.|||       .||.:.|
Mouse    89 ------------GDVPASQTTKPPLQLILDPSNTEISTPRP-------SSPSRFP---------- 124

  Fly   442 GHKEHSDGSQPLAANSQLEAPNVIVNK-------QPTPPRDQGVGTGTASASAGPSQLHP---NY 496
                              |..:|:.||       :.:.||.: |....|.|:...|..:|   ..
Mouse   125 ------------------EEDSVLFNKLTYLGCMKVSSPRSE-VEALRAMATMRASSQYPFAVTL 170

  Fly   497 AMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKS 561
            .:.|:|:...|         .::|:..:                 ::..:..:| |..|..|
Mouse   171 YVPNVPEGSVR---------IIDQSSNV-----------------EIASFPIYK-VLFCARG--- 205

  Fly   562 LDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIFSCE--HCPML 624
                        :||        .:|..|        .||...:...::....:||||  .....
Mouse   206 ------------HDG--------TAESNC--------FAFTESSHGSEEFQIHVFSCEIKEAVSR 242

  Fly   625 WYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHC 689
            ..:..||..:            |....:||.:..::            |..:.:.|...:.....
Mouse   243 ILYSFCTAFK------------RSSRQVSDVKDSVI------------PTPDSDVFTFSVSLEVK 283

  Fly   690 ESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAV---------P 745
            |...:.:.....::|.:|          :.|.|:.:.......:::..:| ::|:         |
Mouse   284 EDDGKGNFSPVPKDRDKF----------YFKIKQGIEKKVVITVQQLSNK-ELAIERCFGMLLSP 337

  Fly   746 SHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIFIKVG-NSPKEAET 809
            .   |:::......|..:|..:.:..|:..:..          :.:|...||:.:. .:||:...
Mouse   338 G---RNVKNSDMHLLDMESMGKSYDGRAYVITG----------MWNPNAPIFLALNEETPKDKRV 389

  Fly   810 HQGSWRQAILNSVVTPSKGLDSEVP-----------------TE-FLSPMRKPAKRGKRDAAELR 856
            :.......::..||.|.:.|...|.                 || |...:::...:|...|.:
Mouse   390 YMTVAVDMVVTEVVEPVRFLLETVVRVYPANERFWYFSRKTFTETFFMRLKQSEGKGHSSAGD-- 452

  Fly   857 ELWRTAIRQTIMLNRMETENAML---------------QARQNENELKRIKLDYEEIVPCDKQLI 906
                 ||.:.:.|.|...:...:               ...:::|||.....|..:  .|.::::
Mouse   453 -----AIYEVVSLQRESDKEEPITPTSAGGPMSPQEDEAEEESDNELSSGTGDVSK--DCPEKIL 510

  Fly   907 ERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTP 971
            ..|.:::.|....:|.:  ||.|...:::|||.:.|.:||..||..|. |...:|         .
Mouse   511 YSWGELLGRWHNNLGGR--PKGLFTLVKSGVPEALRAEVWQLLAGCHD-NQEMLD---------K 563

  Fly   972 YHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICG 1036
            |.:|:...:..:..|..|:.||||.|.::||..|.||.||:.:.||||:.|.::|||||..|:..
Mouse   564 YRILITKDSAQESVITRDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVFDEDIGYCQGQSFLAA 628

  Fly  1037 VLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPT 1101
            |||||..|..:|.:|..:|:...:|..|..:.:....:.|||.:|:::.|||||......::...
Mouse   629 VLLLHMPEEQAFCVLVTIMYGYKLRDLYRNNFEDLHCKFYQLEKLMQEQLPDLYSHFCDLNLEAH 693

  Fly  1102 LYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKT 1166
            :||:.|.||:|:::|||..|..:.|||..|..::||..|:|||...|:.||..| ||..:.:.:.
Mouse   694 MYASQWFLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQAD-FEGALKFFRV 757

  Fly  1167 VVPK-----------MEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREK 1220
            .:||           ||..|..::..        |:|.:|:.||..::|........::...||.
Mouse   758 QLPKRYRAEENARRLMEQACNIKVPT--------KKLKKYEKEYQAMRENQLQQEDPMDRYKREN 814

  Fly  1221 TQNQHLEQQLQFAQSSIA-QLETTRSSQQAQITTLQSQV----QSLELTIQTLGRYVGQLVEHNP 1280
            .:.|....:|:.....:| :|.|::.:.:..:...:.:.    :.|..|.|.|
Mouse   815 RRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLFTKQRL------------ 867

  Fly  1281 DLELPNEVRRMLQQLDDLDRQRRKPI-FTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQ 1344
             :|...|.|:..::...|....||.: ..|.:|.|:.::             :.|..::.|....
Mouse   868 -VETEEEKRKQEEETAQLKEVFRKQLEKAEYEIKKTTAI-------------IAEYKQICSQLST 918

  Fly  1345 KKEKTPFFEQLRQQQQQHRLNGGGQ-----SSNVGESGS--PTPPSRPNRLLDNASARTVMQVKL 1402
            :.||    :|...:::...:.|...     |....:.|:  |...:|.::.|:....:..::.:|
Mouse   919 RLEK----QQAASKEELEAVKGKMMACKHCSDIFSKEGALKPVAVNREDQGLEADDEKDSLKKQL 979

  Fly  1403 DELKLPEHVDKFVANIKSPL--------EVDSGVGTPLSPPSTASNS----SGGSIFSRMGYRTT 1455
            .|::|.      :|..|..|        |::...|..::....|.||    :..||.:..|.:..
Mouse   980 REMELE------LAQTKLQLVEAKCKIQELEHQRGALMNEIQAAKNSWFSKTLNSIKTATGTQPL 1038

  Fly  1456 PPALSPLAQRQS 1467
            .|..:|...::|
Mouse  1039 QPPQAPQPPKES 1050

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	51/298 (17%)
		DUF3350	831..880	CDD:463365	10/81 (12%)
		TBC	933..1152	CDD:214540	79/218 (36%)
		COG4372	<1190..>1353	CDD:443500	30/168 (18%)
Rabgap1l	XP_006496938.1	PTB_Rab6GAP	129..257	CDD:269922	31/198 (16%)
		DUF3694	290..421	CDD:463599	21/154 (14%)
		RabGAP-TBC	541..744	CDD:459855	76/212 (36%)
		Smc	<797..>1018	CDD:440809	40/256 (16%)