Protein Alignment plx and Sgsm1

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_063127295.1
• Gene: Sgsm1 / 288743
• RGDID: 1308178
• Length: 1148
• Species: Rattus norvegicus
• Alignment Length: 1176
• Identity: 223/1176 - (18%)
• Similarity: 381/1176 - (32%)
• Gaps: 383/1176 - (32%)

  Fly   121 RHTLTASTSYGSLSSSAACAYQLQLQQSAEASAEQPQNFMEFQGPITGLVY----LLKDPKDPLL 181
            ||   :|.|.....|.:|..|...|.|::.|:                |:|    :|..|:|.:.
  Rat   227 RH---SSGSMDDRPSISARDYVESLHQNSRAT----------------LLYGKNNVLVQPRDDME 272

  Fly   182 HI--YLFECEAVEEMAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATN 244
            .:  ||    ::.:.|::|.....|...:.||||.:...                ..::...|..
  Rat   273 AVPGYL----SLHQTADVMTLKWTPNQLMNGSVGDLDYE----------------KSVYWDYAVT 317

  Fly   245 LKMSEAMRNAQHDTSPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTHF 309
            :::.|.:                   ..:.|....|.|||.:    .:|..:.......|...|.
  Rat   318 IRLEEIV-------------------YLHCHQQVDSGGTVVL----VSQDGIQRPPFRFPKGGHL 359

  Fly   310 FEVMYVGKIRVSQKRVPNTFIDDAL----PKFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSS 370
            .:.:..    :....:|:..:|..|    .|.|.:...|.|..|....|.||:
  Rat   360 LQFLSC----LENGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSSESTSSD------------ 408

  Fly   371 LKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRG 435
                  ||:||......:.......|:   .|.|.|.|     :|||:     :..|....|..|
  Rat   409 ------KEDDEATDYVFRIIYPGTQSE---FVTLDLLG-----SPRPM-----SVGPAWMMLAAG 454

  Fly   436 QSQIELGHK---EHSDGSQPLAANSQLEAP-------NVIVNKQPT----PPRDQGVGTGTASAS 486
            .|.:.:...   ..:.|.|.:...|..|.|       :|.:|..|:    .||.....:.:.|.|
  Rat   455 HSVLVVARGLQWAQTRGCQTVPTRSVKEQPPMPQDLMDVSMNNLPSLWQPSPRKSSCSSCSQSGS 519

  Fly   487 AGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKD 551
            |                  |.|::.||       |..      |..|:|:..:.|..:|.:.|..
  Rat   520 A------------------DGSSTNGC-------NHE------RAPLKLLCDNMKYQILSRAFYG 553

  Fly   552 -VASCVHGQKSLDHFG------IICRELNNDGYIGYVFKCQSEHVCDD----------------I 593
             :|.|.|......|..      |:..:|..|...|.......:::.|.                :
  Rat   554 WLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTASIWEQYIQDSTTYPEQELLRLIYYGGV 618

  Fly   594 VAAIAQA----------FDTCAEQKKKQDTQIFSCEHCPML-WYHKLCTDVEGLSEKKTQAL--- 644
            ...|.:|          |.....::|:.|.||.:|....|. |..  |..:....|:::.|.
  Rat   619 QPEIRRAVWPFLLGHYQFGMTEMERKEVDEQIHACYAQTMSEWLG--CEAIVRQRERESHAAALA 681

  Fly   645 --------------ILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQR 695
                          :|.|..|:|::.     ::.|.|.:.|             ||...:|....
  Rat   682 KCSSGASLDSHLHRMLHRDSTISNES-----SQSCSSGRQN-------------LRLQSDSSSST 728

  Fly   696 HVHDT--------AENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDI 752
            .|.::        ||.|||                           ::.|.     :|:.|..:
  Rat   729 QVFESVDEVEQTEAEGRSE---------------------------EKHPK-----IPNGNPAN- 760

  Fly   753 REGSAEPLGTQSPPEGFRSRSN-TVGASPSSKPTAEQLKSPMMDIFIKVGNSPKEAETHQGSWRQ 816
                    ||.||..|..|..| :.|.|..|:|:. ..:..::|:                   |
  Rat   761 --------GTCSPDSGHPSSHNFSSGLSEHSEPSL-STEDSVLDV-------------------Q 797

  Fly   817 AILNSVVTP-----SKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETEN 876
            ..|.:|..|     ..|..||..|             .||.|...||   |::.:     :|::
  Rat   798 RSLPAVFRPGDSSVEDGQSSEATT-------------SRDEAPREEL---AVQDS-----LESD- 840

  Fly   877 AMLQARQNENELKRIKLDYEEIVP-CDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRS 940
              |.|.::..|...|....:..:| .|..:::.|.                   |.|.:.|
  Rat   841 --LLANESLEEFMSIPGSLDVALPEKDGAMMDGWP-------------------GEADKHG---- 880

  Fly   941 KRGDVWTFLAEQHSM------------------NTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIF 987
             |.|....|:|:..|                  .|:||.:...    |....||...|.:.|.|.
  Rat   881 -RADSEDNLSEEPEMESLFPALASLAVTSSANNETSPVSSSGV----TYSPELLDLYTVNLHRIE 940

  Fly   988 IDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGL-GFICGVLLLHCDEANSFQLL 1051
            .|:.|...:: :|.....|.:|.  |::.:|.....|:||.||: ..:..:|::..|||.:|...
  Rat   941 KDVQRCDRSY-WYFTAANLEKLR--NIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCF 1002

  Fly  1052 KHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQN-DVSPTLYAAPWILTVFSSQ 1115
            ..||.|.|....:...|......:..|.:::...|.:|   :.|| |.:...:...|.|..|..:
  Rat  1003 TELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFEL---MHQNGDYTHFYFCYRWFLLDFKRE 1064

  Fly  1116 FPLGFVARVFDLLF----LESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCM 1176
            .....|..|::.::    :.|:..:...|:||:.|::..:|  :|..:..|.:|......|....
  Rat  1065 LVYDDVFSVWETIWAAKHVSSAHYVLFIALALVEVYRDIIL--ENNMDFTDIIKFFNEMAERHNA 1127

  Fly  1177 EQIMKL 1182
            :||::|
  Rat  1128 KQILQL 1133

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	64/350 (18%)
		DUF3350	831..880	CDD:463365	10/48 (21%)
		TBC	933..1152	CDD:214540	53/242 (22%)
		COG4372	<1190..>1353	CDD:443500
Sgsm1	XP_063127295.1	None