Protein Alignment plx and gyp51

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_594886.1
• Gene: gyp51 / 2542680
• PomBaseID: SPAC26F1.09
• Length: 1031
• Species: Schizosaccharomyces pombe
• Alignment Length: 1167
• Identity: 245/1167 - (20%)
• Similarity: 420/1167 - (35%)
• Gaps: 328/1167 - (28%)

  Fly   253 NAQHDTSPN-PVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNL---SLLADISPNHTHFFEVM 313
            |:..|:.|| |....|:...|.......|....|..|:|...:::   |:.||||       :|.
pombe    80 NSFADSIPNEPEIPDMQDEYSRDSHSQQSVEEQNNTTNTDEDASVNEFSVAADIS-------DVN 137

  Fly   314 YVGKIRVSQKRVPNTFIDDALPKFKAYDAQRLRLLQN----RKMSLSSEGGVGIEAKPSS----- 369
            .:||........|...:::.            ..|.|    .:....||   |::.:|.|
pombe   138 TLGKDNSESTEEPVNEVNET------------ATLGNEDVGERSGFPSE---GLDNEPESQRDLD 187

  Fly   370 ---SLKSHDLKEEDE------------EEQEQHKGHDDSQDSQAKPLVQL----QLTGAEEGAAP 415
               :|...|||:|.:            :::|.:...||:..::.:.:.::    ||:.|:|....
pombe   188 ETGNLAPEDLKDEVKSVHEFNEPNDLRQQEESYSDDDDTNVNEFEDVNEIENEHQLSVADEDQTS 252

  Fly   416 RPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGT 480
            |               |::|: .|.:|.::..:         :.:..|.:..:|..|..|...|.
pombe   253 R---------------LVKGK-MIFVGKEDFGE---------EADISNSVFIEQNGPNSDTVSGF 292

  Fly   481 GTASASAGPSQL--HPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQV 543
            ...|:....|..  .|..|:|:                   ||.|.:|           .:.:..
pombe   293 KETSSIVNSSSTTEKPGVALDS-------------------QNDTSIF-----------NEEQTN 327

  Fly   544 LLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQK 608
            .|.:.|.|:        :|||.                    .|:|..:.||  .:..:|...:.
pombe   328 SLTETFNDL--------TLDHL--------------------PENVESEPVA--GKENETAKNES 362

  Fly   609 KKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQE----IVWAK---FCG 666
            ...|....:..|..:|   |...|...|:|:|        |.| .||..|    ||.:.   |..
pombe   363 GASDNDHKANVHVFVL---KSSEDAITLNEEK--------IAT-QDDPLEAPTPIVASSSTIFLN 415

  Fly   667 SEKTNSPVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDN 731
            |.:.|..::             ....|:.|..|...:.|                  ||....:|
pombe   416 SNQRNDELS-------------ASGSQEPHPKDGTNSTS------------------SLPLDTNN 449

  Fly   732 LLKRKPSKDDIAVPSHNLRDIREGSAEPLGT-----QSPPEGFR---SRSNTVGASPSSKPTAEQ 788
            |...:|       |||.| |....:.|.:.|     ...||..:   .:.|| ..||.:..:...
pombe   450 LSNSEP-------PSHVL-DASSETIEVIQTIKKLQNQVPETIKDEVGKKNT-AFSPGTSLSTNH 505

  Fly   789 LKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPS----KGLDSEVPTEFLSPMRKPAKRGK 849
            :|:......   .||.....|...||    ||.:..||    :.:.|.:.:.|:|   ||...|.
pombe   506 VKTKSRSAH---NNSTSPFSTAVSSW----LNPLRYPSDKSPRVISSYLESVFIS---KPRSIGD 560

  Fly   850 RDAAELRELWR----TAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWE 910
            ....|:.|..:    |...|...|.....:|.:....:..:|.:.:
pombe   561 AQKLEILEYLQSQSSTVSNQVFTLLSNFIQNPLFVLDECFDEFRNL------------------- 606

  Fly   911 QIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHML 975
             |:..||             |.:.|        .||..::...|.           ::...|..|
pombe   607 -ILMHNS-------------HTVHT--------VVWKTISSWTSY-----------DYEMQYSSL 638

  Fly   976 LKHLTEHQHAIFIDLGRTFP----NHQFYK-------DPLGLGQLSLFNLLKAYSILDPELGYCQ 1029
            .....:...||..||.|||.    :|.|..       |.:.....:|..:|::.:|:.|::||.|
pombe   639 SIKNCDSDKAIRKDLDRTFAPEILSHFFSNRQQLEPTDNIAESTANLHRVLRSLAIVLPQVGYTQ 703

  Fly  1030 GLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLD 1094
            |:.:|.|.||:|.....:|.||..|....:::..:..:|:.....|:|.:|||:|::|.|.:...
pombe   704 GMSWIAGALLMHLPAPQAFALLVFLFKNYHLQNIFSSEMRGLSRVLHQFTRLVEDYMPSLAIHFK 768

  Fly  1095 QNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEE 1159
            :.|:....||:.|.||:|:.:|||..||.::|:|||....::|.|.:|||| |.|:.|.|.|.:.
pombe   769 RQDIKTCSYASEWFLTLFAYKFPLEVVAHLYDILFLYGPGILFNFGLALLS-HSQESLLKLNMDR 832

  Fly  1160 IMDYLKTVV-------PKMEHTCMEQIMKLVFSMDIGKQ-LAEYKVEYNVLQEEITTTNHHL--- 1213
            ::.|||..:       .:.|:......:|..||.:|... |..|..||::|.:    :.|.|
pombe   833 LISYLKEDIFLAFKETQEGENYDTSLFVKTAFSFEIQPDVLDRYGNEYDILLK----SEHELDSS 893

  Fly  1214 --EMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQI--------------TTLQSQVQSLE 1262
              ||.||.|:.|:|    ......|:|.|:....:..|.:              .:|:|::.||.
pombe   894 LEEMRNRHKSLNEH----FIMLSDSMANLQVEHENMSALLLKEKMYLKNQTVEQASLKSEIASLN 954

  Fly  1263 LTIQTLGRYVGQLVEHNPDLELPNEVRRML--QQLDDLDRQRRKPIFTERKIGKSVSVNSHL 1322
            ..:......:.|..:.:.:..:...:..|:  |.|:| :..|::....|.|:..:|....|:
pombe   955 SQLAKQKSEIEQAFQGDMEAIIAENLEIMVESQSLED-EIFRKEKQLAETKVNLAVLDEDHM 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	55/329 (17%)
		DUF3350	831..880	CDD:463365	12/52 (23%)
		TBC	933..1152	CDD:214540	66/229 (29%)
		COG4372	<1190..>1353	CDD:443500	32/155 (21%)
gyp51	NP_594886.1	COG5210	233..890	CDD:227535	184/860 (21%)
		DR0291	888..>1010	CDD:441187	25/126 (20%)