DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and SPCC1620.12c

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	NP_001342783.1	Gene:	SPCC1620.12c / 2538866	PomBaseID:	SPCC1620.12c	Length:	640	Species:	Schizosaccharomyces pombe

Alignment Length:	707	Identity:	126/707 - (17%)
Similarity:	250/707 - (35%)	Gaps:	193/707 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   744 VPSHNLRD-IREGSAEPLGTQSPPEGFRSRSNTVGASPSSKPTAEQLKS-PMMDIFIKVGNSPKE 806
            |...||:: ::.|||..:|:...........:...:|||.:.|.||.:. ..:|..:.....|:|
pombe    19 VKQENLKENLQNGSAVSVGSSESSNHSMKEISLDYSSPSLQQTEEQDRELNFIDSSMLRPTPPQE 83

  Fly   807 AETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGK-----RDAAELRELWRTAIRQT 866
            ::.     |.|:....:.|.:| .|.||: |:|.........|     .:..:||:.:::
pombe    84 SDN-----RLAVEKPNIQPLQG-HSPVPS-FMSTASTNISSSKINNNQTEFEQLRDSYKS----- 136

  Fly   867 IMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIE-------RWE-------------- 910
                     :..|.:..|::.::.|..:..:  .|:|:.|.       :|.
pombe   137 ---------HGDLNSAINDSRIQSIIFELNQ--QCEKESIPVSNIDWLQWASVPLFAYDLPPDPS 190

  Fly   911 ----------------QIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAP 959
                            ::|::|:..|     |......:...:..::|.::.|..|...:.|.:
pombe   191 NPNATSSSPPPLTPILELIKQNNFCI-----PSPCRKLVWQSLVSAERNELLTLYATLSTTNNS- 249

  Fly   960 VDTK-----RFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYS 1019
            :|:.     |..:|..|... .|:.:..:|.:..:                    |:|::|.|::
pombe   250 LDSSIRKIIRMQSFRGPLEP-FKYSSTTRHKVSTE--------------------SIFHVLHAFT 293

  Fly  1020 ILDPELGY-CQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLS-RLV 1082
            :.|..:.| .:.|.::....|.:..:.|:|:.|...:.|..:|..::.........|:.|. ..:
pombe   294 LFDTTVEYNIEPLLWLTCAFLSYMAQGNAFRSLVCFIQRGGIREFFISQSSSLDESLFALVWGCL 358

  Fly  1083 KDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIAL---- 1143
            .|..|.:.:.|.:..||......|.:...|:....|....|:.||:.:...::..:..:|:
pombe   359 GDLAPSVAISLQRIKVSSLCILYPSLACCFADSLQLPEALRLMDLIAIYGLEMFVRLLVAIFLKD 423

  Fly  1144 ---------------------LSVHKQQLLAKDNF----------------------EEIMDYLK 1165
                                 |:.::|.|:.|..|                      .:...||.
pombe   424 RDKIVNMVSHEQWVKYLRSDVLASYRQPLVQKYTFYTRTPVDLNAWVEDSLALNIDTTQFPSYLS 488

  Fly  1166 TVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQL 1230
            .....:.|....|           ..|.|.|.:.:.|..:||.....:.|||:|.|:
pombe   489 YHETSVSHNTYRQ-----------NNLEELKNQNDYLTSQITNLEEGMVMLNKENTK-------- 534

  Fly  1231 QFAQSSIAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQL 1295
              ...:::....|||..:.....|::  .|.:|..|         :|..|. ||.|   |:||::
pombe   535 --LSEALSNHRVTRSEMEEATEILKN--NSADLKAQ---------LEKQPQ-ELEN---RLLQEI 582

  Fly  1296 DDLDRQRRKPIFTER---KIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKT 1349
            ..|.::.:|  |.:.   .|.:...::..||..||.|.:|.|:    ..|.|.|.|:
pombe   583 SILKQRNQK--FLKNNATSIQQIQYLDEELGKTLKQLNDLKEK----HAQLQTKWKS 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	835..880	CDD:288663	5/49 (10%)
		TBC	933..1152	CDD:214540	39/250 (16%)
		RILP-like	<1176..1267	CDD:304877	18/90 (20%)
SPCC1620.12c	NP_001342783.1	COG5210	29..500	CDD:227535	81/520 (16%)
SPCC1620.12c	NP_001342783.1	DUF812	<500..636	CDD:310341	42/176 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910