Protein Alignment plx and RABGAP1

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_036329.3
• Gene: RABGAP1 / 23637
• HGNCID: 17155
• Length: 1069
• Species: Homo sapiens
• Alignment Length: 1200
• Identity: 275/1200 - (22%)
• Similarity: 488/1200 - (40%)
• Gaps: 251/1200 - (20%)

  Fly   356 SSEGGVGIEAKPSSSLKSHD---LKEEDEEEQEQHKGHDDSQDSQAKPLV------QLQLTGAEE 411
            :|.|.:.:.:...|:|.|.|   :..:.:|....:.|.||  :.....:|      |||...|:.
Human     5 ASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDD--EKTGLKIVGNGSEQQLQKELADV 67

  Fly   412 GAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTP---- 472
            ...| |::|....|...||..|.|            :|..||  ::||.|.:.|   .|.|
Human    68 LMDP-PMDDQPGEKELVKRSQLDG------------EGDGPL--SNQLSASSTI---NPVPLVGL 114

  Fly   473 -------PRDQGVGTGTASASAGP---------SQL-HPNYAMDNIPKQRDRSASQGCIPPYVEQ 520
                   |...|.|...||:...|         |:| :...|..|.|:..            ||.
Human   115 QKPEMSLPVKPGQGDSEASSPFTPVADEDSVVFSKLTYLGCASVNAPRSE------------VEA 167

  Fly   521 NRTMVFLVGRCDL----------------RLISPD-RKQVLLYKDFKDVASCVHGQKSL---DHF 565
            .|.|..|..:|.:                ||:.|. ..::..|..:| :..||.|....   |.|
Human   168 LRMMSILRSQCQISLDVTLSVPNVSEGIVRLLDPQTNTEIANYPIYK-ILFCVRGHDGTPESDCF 231

  Fly   566 GIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQ--------KKKQDTQIF----SC 618
            .......|.:.:..:||:|:.:.....|:.:.|.||...|:|        .:..|:.||    |.
Human   232 AFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSL 296

  Fly   619 EHCPMLWYHKLCTDVEGL-----SEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQN 678
            |...        .|.:|.     .:|..|...||:    ..|::.:::.:    :.||..:|.:.
Human   297 EIKE--------DDGKGYFSAVPKDKDRQCFKLRQ----GIDKKIVIYVQ----QTTNKELAIER 345

  Fly   679 QFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIA 743
            .|.::|...........|:.|.     |.:.:...|.:..:....:..:....::..:..||.:.
Human   346 CFGLLLSPGKDVRNSDMHLLDL-----ESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVL 405

  Fly   744 VPSHN----LRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSK---PTAEQLKSPMMDIFIKVG 801
            ..:..    :.:::|           |..|...:.....||:.:   |.::  :|...:.|:|:
Human   406 FMTTAVDLVITEVQE-----------PVRFLLETKVRVCSPNERLFWPFSK--RSTTENFFLKL- 456

  Fly   802 NSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQT 866
               |:.:..:.......|..||.    |:||            ::|.:|         :|....:
Human   457 ---KQIKQRERKNNTDTLYEVVC----LESE------------SERERR---------KTTASPS 493

  Fly   867 IMLNRMETENAMLQARQNENELKRIKLDYEEIV---------PCDKQLIERWEQIIERNSTQIGN 922
            :.|.:..::::::.:...::|    :.|.:|.:         .|.::::|.|.:::.:....:..
Human   494 VRLPQSGSQSSVIPSPPEDDE----EEDNDEPLLSGSGDVSKECAEKILETWGELLSKWHLNLNV 554

  Fly   923 KKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIF 987
            :  ||.|...:|.|||.:.||:||..||..|: |...|:         .|.:|:...:....||.
Human   555 R--PKQLSSLVRNGVPEALRGEVWQLLAGCHN-NDHLVE---------KYRILITKESPQDSAIT 607

  Fly   988 IDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLK 1052
            .|:.||||.|.::||..|.||.||:.:.||||:.|.|:|||||..|:..|||||..|..:|.:|.
Human   608 RDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLV 672

  Fly  1053 HLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFP 1117
            .:||...:|..:..:.:....:.|||.||:::::||||.......:...:||:.|.||:|:::||
Human   673 KIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFP 737

  Fly  1118 LGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPK--MEHTCMEQIM 1180
            |..|..:.|||..|...|||..|:.||...|..||..| ||..:.:.:..:||  ......:::|
Human   738 LYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTD-FEGALKFFRVQLPKRYRSEENAKKLM 801

  Fly  1181 KLVFSMDIG-KQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIA-QLETT 1243
            :|..:|.|. |:|.:|:.||:.::|:.......:|...||..:.|....:|:.....:| :|.|:
Human   802 ELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLAHELVTS 866

  Fly  1244 RSSQQAQITTLQSQVQSLE----LTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQ-RR 1303
            :.:.:..:...:.:..:|.    :|.|.|             ::...|.||:.::...|... ||
Human   867 KIALRKDLDNAEEKADALNKELLMTKQKL-------------IDAEEEKRRLEEESAQLKEMCRR 918

  Fly  1304 KPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQ---------- 1358
            :....|.:|.|:.|:   :|...::..:|:||.|     ||:.......|::||:
Human   919 ELDKAESEIKKNSSI---IGDYKQICSQLSERLE-----KQQTANKVEIEKIRQKVDDCERCREF 975

  Fly  1359 -QQQHRLNGGGQSSNV-GESGSPTPPSRPNRL--LDNASARTVMQVKLDELKLP--EHVDKFVAN 1417
             .::.|:.|...:..| .|.......:..|:|  ::...|:|.:|:...|.|:.  ||......|
Human   976 FNKEGRVKGISSTKEVLDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQDLEHHLGLALN 1040

  Fly  1418 IKSPLEVDSGVGT----PLSPPSTASNSSG 1443
                 ||.:...|    .||...||:...|
Human  1041 -----EVQAAKKTWFNRTLSSIKTATGVQG 1065

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	65/294 (22%)
		DUF3350	831..880	CDD:463365	6/48 (13%)
		TBC	933..1152	CDD:214540	83/218 (38%)
		COG4372	<1190..>1353	CDD:443500	35/168 (21%)
RABGAP1	NP_036329.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79		18/76 (24%)
		PTB_Rab6GAP	145..273	CDD:269922	30/140 (21%)
		DUF3694	307..437	CDD:463599	21/153 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	482..527		7/57 (12%)
		TBC	563..772	CDD:214540	83/218 (38%)
		SMC_prok_B	<825..>1032	CDD:274008	44/227 (19%)