DRSC/TRiP Functional Genomics Resources

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Protein Alignment plx and TBC1D1

DIOPT Version :9

Sequence 1:NP_001163511.1 Gene:plx / 40704 FlyBaseID:FBgn0261261 Length:1572 Species:Drosophila melanogaster
Sequence 2:XP_011511961.1 Gene:TBC1D1 / 23216 HGNCID:11578 Length:1295 Species:Homo sapiens


Alignment Length:1401 Identity:406/1401 - (28%)
Similarity:599/1401 - (42%) Gaps:449/1401 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 PITGLVYLLKDPK--------------DPLLHIYLFECEAVEEMAELMHQMRDPAHTLGGSVGSI 215
            |:|..|.|...|.              |||::..:|||:. :.:.:|:|...||::.        
Human    59 PVTKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKP-QRVHKLIHNSHDPSYF-------- 114

  Fly   216 PQTLIGGGGGSHGNSNGALNGIHATPATNLKMSEAMR-------NAQHDTS-PNPVSSKMKASKS 272
                                      |..:|.....|       .|...|. |..:||..:|.| 
Human   115 --------------------------ACLIKEDAVHRQSICYVFKADDQTKVPEIISSIRQAGK- 152

  Fly   273 YTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTHFFEVMYVGKIRVSQKRVPNTFIDDALPKF 337
                             .:.|..|...::.....:..|||::.|::.|:.|:.|...||:.:.||
Human   153 -----------------IARQEELHCPSEFDDTFSKKFEVLFCGRVTVAHKKAPPALIDECIEKF 200

  Fly   338 KAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLV 402
                                               :|.......|....:..|       |.|  
Human   201 -----------------------------------NHVSGSRGSESPRPNPPH-------AAP-- 221

  Fly   403 QLQLTGAEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVN 467
                ||::|               |.:||:.:..||         .|.:.||...:|:       
Human   222 ----TGSQE---------------PVRRPMRKSFSQ---------PGLRSLAFRKELQ------- 251

  Fly   468 KQPTPPRDQGVGTGTASASAGPSQLHPNYAMD--NIPKQRDRSASQGCIPPYVEQNRTMVF---- 526
                   |.|:.:....:|...|.:. |:.:.  ||.:..|           :|:||||:|    
Human   252 -------DGGLRSSGFFSSFEESDIE-NHLISGHNIVQPTD-----------IEENRTMLFTKDK 297

  Fly   527 ----------------LVGRCDLRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNND 575
                            .:|:.::.|||||.|::.|.|:||:::.|..|.:.:||||.||||.:..
Human   298 SKRLPATLCWLKYSSETIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGG 362

  Fly   576 G---YIGYVFKCQSEHVCDDIVAAIAQAFDTCA-EQKKKQDTQIFSCEHCPMLWYHKLCTDVEGL 636
            |   ::.|||:|.:|.:.|:|:..:.|||...| :|..|...|:  ||.||:...||||..:||:
Human   363 GGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQL--CEGCPLQSLHKLCERIEGM 425

  Fly   637 SEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMMLLRAHCESRQQRHVH--- 698
            :..||:..:.:.:.||::.||..::.:.......|.  ..:|:.::..||...|.:|:.|:|   
Human   426 NSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNE--QRENELIISFLRCLYEEKQKEHIHIGE 488

  Fly   699 --DTAENRSEFLNQYLGGS-TIFM------KAKRSLTNSFDNLLKR------------------- 735
              .|::..:|.:...|..| |.|.      |||||||.|.:::|.|                   
Human   489 MKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSS 553

  Fly   736 ----------KPS---KDDIAVPSHNLRDIREGSAEPLGTQ------------SPPEGFRSRSNT 775
                      :||   |:.:.:...:.:.:  ||:|.|.:.            ||.:.||.|:||
Human   554 LSSTLSNTSKEPSVCEKEALPISESSFKLL--GSSEDLSSDSESHLPEEPAPLSPQQAFRRRANT 616

  Fly   776 ----------------------------------------------VGAS-------------PS 781
                                                          ||.|             |.
Human   617 LSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERNVDPSPVGESKHRPGQSSAPAPPPR 681

  Fly   782 SKPTAEQLKSPMMDIFIKVGNS--------PKE-------------------------------- 806
            ..|:|   .||....::|..:|        ||.                                
Human   682 LNPSA---SSPNFFKYLKHNSSGEQSGNAVPKSISYRNALRKKLHSSSSVPNFLKFLAPVDENNT 743

  Fly   807 ------------------------AETHQGSWRQAILNSVVTPSKGLDS----EVP--------- 834
                                    .:|.:.||||.|...|.||.|..||    |.|         
Human   744 SDFMNTKRDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEEPHCGSPSLAC 808

  Fly   835 TEFLS------------------PMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQA 881
            ||..|                  |...|.:..||.:.||||||:.||.|.|:|.|||.||..|||
Human   809 TEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQA 873

  Fly   882 RQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKK---DPKVLGHAIRTGVPRSKRG 943
            .:|:...||:|||||||.||.|::...||:::   ||. |..|   |.:.:..|:..||||..||
Human   874 SENDLLNKRLKLDYEEITPCLKEVTTVWEKML---STP-GRSKIKFDMEKMHSAVGQGVPRHHRG 934

  Fly   944 DVWTFLAEQ-HSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLG 1007
            ::|.||||| |..:..|  :|:.|. :.||..|||.||..||||.||||||||.|.::...||.|
Human   935 EIWKFLAEQFHLKHQFP--SKQQPK-DVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAG 996

  Fly  1008 QLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQ 1072
            ||||:|:|||||:||.|:||||||.|:.|:||||..|..:|::||.|||...:|.:|.|||...|
Human   997 QLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQ 1061

  Fly  1073 LQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIF 1137
            :|:||||||:.|:..|||..|:::::.|:||||||.||:|:|||||||||||||::||:.::|||
Human  1062 IQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIF 1126

  Fly  1138 KFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVL 1202
            |.|::||..||..:|..:|.|.|:|::|:.:|.:....||:.:..||.|||.|||..|:|||:||
Human  1127 KVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVL 1191

  Fly  1203 QEEI-----TTTNHHLEMLNREKT------QNQHLEQQLQFAQSSIAQLETT-------RSSQQA 1249
            |||:     .:.|..::.|  |||      ||..|.:|||.|...|..||.|       .|..:.
Human  1192 QEELIDSSPLSDNQRMDKL--EKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQ 1254

  Fly  1250 QITTLQSQVQSLELTIQTLGRYVGQLVEHNPDLELP 1285
            .:.||:.:..:|..|::.|.|...:..:..|:...|
Human  1255 AMLTLELERSALLQTVEELRRRSAEPSDREPECTQP 1290

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plxNP_001163511.1 PTB_TBC1D1_like 301..601 CDD:269967 72/324 (22%)
DUF3350 835..880 CDD:288663 23/62 (37%)
TBC 933..1152 CDD:214540 123/219 (56%)
RILP-like <1176..1267 CDD:304877 40/108 (37%)
TBC1D1XP_011511961.1 PTB 21..150 CDD:269911 23/125 (18%)
PTB_TBC1D1_like 164..391 CDD:269967 72/324 (22%)
CytochromB561_N 563..>871 CDD:286826 63/312 (20%)
DUF3350 822..872 CDD:288663 20/49 (41%)
TBC 924..1141 CDD:214540 123/219 (56%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 245 1.000 Domainoid score I2183
eggNOG 1 0.900 - - E1_KOG4436
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 563 1.000 Inparanoid score I1087
Isobase 1 0.950 - 0 Normalized mean entropy S5505
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D164786at33208
OrthoFinder 1 1.000 - - FOG0003414
OrthoInspector 1 1.000 - - otm40455
orthoMCL 1 0.900 - - OOG6_105859
Panther 1 1.100 - - LDO PTHR22957
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2765
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.780

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