Protein Alignment plx and TBC1D9

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_055945.2
• Gene: TBC1D9 / 23158
• HGNCID: 21710
• Length: 1266
• Species: Homo sapiens
• Alignment Length: 1226
• Identity: 248/1226 - (20%)
• Similarity: 410/1226 - (33%)
• Gaps: 390/1226 - (31%)

  Fly   526 FLVGRCDLRLI-------SPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFK 583
            ||:|| :.:|:       ..::...||..|...|::     :|.:||..:...:|.      .||
Human   191 FLMGR-EAKLVIRWVDITQLEKNATLLLPDVIKVST-----RSSEHFFSVFLNINE------TFK 243

  Fly   584 CQSEHVCDDIVAAIA-------QAFD---TCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSE 638
            ...:      :|.||       :.|:   :..:.|:|...::.:.         |...|....||
Human   244 LMEQ------LANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSAL---------KRDLDARAKSE 293

  Fly   639 KKTQALILRRIETLSDDEQEIVWAKF----------------CGSEKTNS------PVAEQNQFL 681
            :......|.:.|.|.......:|..|                |.:.|..:      |:.|    :
Human   294 RYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLRE----V 354

  Fly   682 MMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSK---DDIA 743
            .::.:|...|.....:..:..||..||...|       |.:..|.....:.|::..||   |...
Human   355 TIVEKADSSSVLPSPLSISTRNRMTFLFANL-------KDRDFLVQRISDFLQQTTSKIYSDKEF 412

  Fly   744 VPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASP----SSKPTAEQLKSPMMDIFIKVGNS- 803
            ..|:|              .|..|.:...|:.|.:||    ||....|:.       |...|||
Human   413 AGSYN--------------SSDDEVYSRPSSLVSSSPQRSTSSDADGERQ-------FNLNGNSV 456

  Fly   804 PKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWR---TAIRQ 865
            |...:|....:|:               ..|.|| :|  |.||...::.|     |:   ....|
Human   457 PTATQTLMTMYRR---------------RSPEEF-NP--KLAKEFLKEQA-----WKIHFAEYGQ 498

  Fly   866 TIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLG 930
            .|.:.|.|        :..|..||
Human   499 GICMYRTE--------KTRELVLK----------------------------------------- 514

  Fly   931 HAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLL-KHLTEHQHA---IFIDLG 991
                 |:|.|.||::|..|:  .::|    :....|.:   |..|: |.:.::..|   |..||.
Human   515 -----GIPESMRGELWLLLS--GAIN----EKATHPGY---YEDLVEKSMGKYNLATEEIERDLH 565

  Fly   992 RTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMF 1056
            |:.|.|..:::.:|:.  :|..:|.||:..:|.:||||.:..:..||||:..|..:|.||..|..
Human   566 RSLPEHPAFQNEMGIA--ALRRVLTAYAFRNPNIGYCQAMNIVTSVLLLYAKEEEAFWLLVALCE 628

  Fly  1057 RRNMRTKYLPDMKKFQLQLYQLSRLV-------------KDHLPDLYVWLDQNDVSPTLYAAPWI 1108
            |      .|||        |..:|:|             :|::|.||..:....|..|: :..|.
Human   629 R------MLPD--------YYNTRVVGALVDQGVFEELARDYVPQLYDCMQDLGVISTI-SLSWF 678

  Fly  1109 LTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL-AKDNFEEIM---DYLKTV-- 1167
            ||:|.|..|......|.|..|.|...|||:.|:|:|..:..:|| .||:.|.:.   .||.:|
Human   679 LTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKLLNCKDDGEAMTVLGRYLDSVTN 743

  Fly  1168 ----VPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQ 1228
                :|.:.|      :..:.|.|:     |...|.::.: .|.|:......:..:..:....:|
Human   744 KDSTLPPIPH------LHSLLSDDV-----EPYPEVDIFR-LIRTSYEKFGTIRADLIEQMRFKQ 796

  Fly  1229 QLQFAQSSIAQLE--TTRSSQQAQITTLQSQVQSLE----------LTIQTLGRYVGQLVEHNPD 1281
            :|:..|:    ||  |.|:..:..:|.....:..||          ||....|.....|..|:|.
Human   797 RLKVIQT----LEDTTKRNVVRTIVTETSFTIDELEELYALFKAEHLTSCYWGGSSNALDRHDPS 857

  Fly  1282 LELPNEVR---------------------------RMLQQLDDLDRQRRKPIFTERKIGKSVSVN 1319
            |....:.|                           |:.|.||:.......  |.|...|.|.:.:
Human   858 LPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQLLDENGDSLIN--FREFVSGLSAACH 920

  Fly  1320 SHLGFPLKVLEELTERDELGSPQKQKK---EKTPFFEQLRQQQQQHRLNGGGQSSNVGESGSPTP 1381
            ..|...||:|.::....|..|.|.:..   |.|.:|.:....:..|.:....:|....:.|..|.
Human   921 GDLTEKLKLLYKMHVLPEPSSDQDEPDSAFEATQYFFEDITPECTHVVGLDSRSKQGADDGFVTV 985

  Fly  1382 PSRPNRLLDNASARTVMQVKLDELKL--PEHVDKFVANIKSPLEVDSG----------------- 1427
            ..:|::     ..|...|...:.|:|  ||:..| ..|.|...:::.|
Human   986 SLKPDK-----GKRANSQENRNYLRLWTPENKSK-SKNAKDLPKLNQGQFIELCKTMYNMFSEDP 1044

  Fly  1428 ---------------------VGTPLSPPSTASNSSGGS-----------IFSRMG--------- 1451
                                 ||............||||           :|.:.|
Human  1045 NEQELYHATAAVTSLLLEIGEVGKLFVAQPAKEGGSGGSGPSCHQGIPGVLFPKKGPGQPYVVES 1109

  Fly  1452 YRTTPPALSPLAQRQSYGVAITTAPCPQHMEEVAP----ATTMAVMPQEDVEEPQPMHPLSM--- 1509
            ....|.:|:|.::..|.|..:...    .:|:.:|    |.:..::..:|.::...|...|:
Human  1110 VEPLPASLAPDSEEHSLGGQMEDI----KLEDSSPRDNGACSSMLISDDDTKDDSSMSSYSVLSA 1170

  Fly  1510 ------------VGGD-VNVRF-KGTTQLKSIRPVHHMRAIPLGGVQHPSSTEPAV 1551
                        :|.| |.||. :||..|.....:....||..........||||:
Human  1171 GSHEEDKLHCEDIGEDTVLVRSGQGTAALPRSTSLDRDWAITFEQFLASLLTEPAL 1226

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	18/88 (20%)
		DUF3350	831..880	CDD:463365	13/51 (25%)
		TBC	933..1152	CDD:214540	67/235 (29%)
		COG4372	<1190..>1353	CDD:443500	39/204 (19%)
TBC1D9	NP_055945.2	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	18/81 (22%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	17/105 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	415..456		14/61 (23%)
		TBC	512..722	CDD:214540	69/281 (25%)
		EFh	<893..923	CDD:415501	8/31 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1075..1095		4/19 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1132..1164		5/35 (14%)