Protein Alignment plx and TBC1D2B

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001374071.1
• Gene: TBC1D2B / 23102
• HGNCID: 29183
• Length: 974
• Species: Homo sapiens
• Alignment Length: 1279
• Identity: 246/1279 - (19%)
• Similarity: 419/1279 - (32%)
• Gaps: 496/1279 - (38%)

  Fly   107 MGGAASSSLTGNGLRHTLTASTSYGSLSSSAACAYQLQLQQSAEASAEQPQNFMEF------QGP 165
            |.||.:.:..|.|        ...|:...:||        :.....|.:|.....:      :||
Human     1 MPGAGARAEEGGG--------GGEGAAQGAAA--------EPGAGPAREPARLCGYLQKLSGKGP 49

  Fly   166 ITG-------------LVYLLKDPKD--PLLHIYL----FECEAVEEMAELMHQMRDPAHTLGGS 211
            :.|             .:|..|.|:|  ||.|:.:    |..:..:|.||  .....|||....|
Human    50 LRGYRSRWFVFDARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAE--PGTEPPAHFQVHS 112

  Fly   212 VGSIPQTLIGGGGGSHGNSNGALNGIHATPATNLKMSEAMRNAQHD----------------TSP 260
            .|::.                    :...|...| |:..::..|..                |||
Human   113 AGAVT--------------------VLKAPNRQL-MTYWLQELQQKRWEYCNSLDMVKWDSRTSP 156

  Fly   261 NP------VSSKMKASKSYTHGLSSSSGTVN------IPTSTSAQSNLSLLADISPNHTHFFEVM 313
            .|      :.::......|.|..:|:....|      :|.....:...:..|...||..:|:.:.
Human   157 TPGDFPKGLVARDNTDLIYPHPNASAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLK 221

  Fly   314 YVGKIRVSQKRVPNTFIDDALPKFKA----YDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSH 374
            ..|           ..:.:::..|:.    .|::|.....|.:..|       ::..|.
Human   222 QWG-----------NELKNSMSSFRPGRGHNDSRRTVFYTNEEWEL-------LDPTPK------ 262

  Fly   375 DLKEEDEEEQ------EQHKGHDDSQDSQAKPLVQLQLTGA----EEGAAP----RPLED---NK 422
            ||:|...:|:      |.:||                :||:    :.|..|    |||:|   :.
Human   263 DLEESIVQEEKKKLTPEGNKG----------------VTGSGFPFDFGRNPYKGKRPLKDIIGSY 311

  Fly   423 ENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGV-GTGTASAS 486
            :|:                    ||.|.                      |..:|. |:|:.|..
Human   312 KNR--------------------HSSGD----------------------PSSEGTSGSGSVSIR 334

  Fly   487 AGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDRKQVLLYKDFKD 551
            ...|::..     .:..|::.          :||.:                           ||
Human   335 KPASEMQL-----QVQSQQEE----------LEQLK---------------------------KD 357

  Fly   552 VASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKKQDTQIF 616
            ::|    ||.|  ..::.:.:.:..|..|.   .|..:|:.:..      || .|...::|.||.
Human   358 LSS----QKEL--VRLLQQTVRSSQYDKYF---TSSRLCEGVPK------DT-LELLHQKDDQIL 406

  Fly   617 SCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFL 681
            .           |.:.:|..|.:|         |:|   :||:...|        |.|.|.|:.|
Human   407 G-----------LTSQLERFSLEK---------ESL---QQEVRTLK--------SKVGELNEQL 440

  Fly   682 MMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIAVPS 746
            .||:                             .||                   .:||::.:
Human   441 GMLM-----------------------------ETI-------------------QAKDEVII-- 455

  Fly   747 HNLRDIREGSAEPLGTQSPPEGFRSRSNTVG-ASPSSKPTA-EQLKSPMMDIFIKVGNSPKEAET 809
                .:.||.    |...||        ||. :|||..|.| :||:...:
Human   456 ----KLSEGE----GNGPPP--------TVAPSSPSVVPVARDQLELDRL--------------- 489

  Fly   810 HQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRD-----AAELRELWRTAIRQTIML 869
                  :..|....|.:|.|:.|:..  ||.:|:.|:|.:||     ::...:|.:...:..|:|
Human   490 ------KDNLQGYKTQNKFLNKEILE--LSALRRNAERRERDLMAKYSSLEAKLCQIESKYLILL 546

  Fly   870 NRMET------------------ENAMLQARQNENELKRIK------------------------ 892
            ..|:|                  |:|:....|.:.|...:|
Human   547 QEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKL 611

  Fly   893 ------LDYEEIVPCDKQLIE---RWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTF 948
                  ||.:.:...:.|.:.   :||....  ||..........|.:.||.|:|...|..||.:
Human   612 VAKVRALDLKTLYLTENQEVSTGVKWENYFA--STVNREMMCSPELKNLIRAGIPHEHRSKVWKW 674

  Fly   949 LAEQHSMNTAPVDTKRFPNFNTPYHM--LLKHLTEHQH----AIFIDLGRTFPNHQFYKDPLGLG 1007
            ..::|        |::|.:...|.|.  ||:...|.|:    .|.:||.||.||::.|..|...|
Human   675 CVDRH--------TRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEG 731

  Fly  1008 QLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLL---KHLMFRRNMRTKYL---- 1065
            ...|.|:|.|:|..:|::||||||..:..|.||:.::.::|..|   ..:...|:..||.|
Human   732 IQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQ 796

  Fly  1066 PDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFL 1130
            .|.:.|:       .|:.:.||.|:...:|..|..||....|.|.||........:.:::|....
Human   797 VDQRVFR-------DLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLY 854

  Fly  1131 ESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYL----KTVVPKMEHTCMEQIMKLVFSMDIG-- 1189
            |...|||:||:||....::::|...:...|..||    :|::         ...||: |:..|
Human   855 EGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTIL---------DARKLI-SISFGDL 909

  Fly  1190 -----KQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQ 1228
                 :|:...:.             :|||.:..|.|:.:.:.:
Human   910 NPFPLRQIRNRRA-------------YHLEKVRLELTELEAIRE 940

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	48/321 (15%)
		DUF3350	831..880	CDD:463365	15/71 (21%)
		TBC	933..1152	CDD:214540	70/231 (30%)
		COG4372	<1190..>1353	CDD:443500	6/39 (15%)
TBC1D2B	NP_001374071.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		8/44 (18%)
		PH_TBC1D2A	36..144	CDD:269966	23/130 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	272..348		21/138 (15%)
		Mplasa_alph_rch	<338..550	CDD:275316	69/389 (18%)
		RabGAP-TBC	707..876	CDD:459855	54/175 (31%)