Protein Alignment plx and Rabgap1

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_666233.2
• Gene: Rabgap1 / 227800
• MGIID: 2385139
• Length: 1064
• Species: Mus musculus
• Alignment Length: 1207
• Identity: 270/1207 - (22%)
• Similarity: 483/1207 - (40%)
• Gaps: 270/1207 - (22%)

  Fly   356 SSEGGVGIEAKPSSSLKSHD---LKEEDEEEQEQHKGHDDSQDSQAKPLV------QLQLTGAEE 411
            :|.|.:.:.:...|:|.|.|   :..:.:|....:.|.||  :.....:|      |||...|:.
Mouse     5 ASVGKISVSSDSVSTLNSEDFVLVSRQGDETPSTNNGSDD--EKTGLKIVGNGSEQQLQKELADV 67

  Fly   412 GAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTP---- 472
            ...| |::|     .|.:|..|.|            :|..||  ::||.|.:.|   .|.|
Mouse    68 LMDP-PMDD-----QPGERSQLDG------------EGDGPL--SNQLSASSTI---NPVPLVGL 109

  Fly   473 -------PRDQGVGTGTASASAGP----------SQLHPNYAMDNIPKQRDRSASQGCIPPYVEQ 520
                   |...|.|....|:...|          ...:...|..|.|:..            ||.
Mouse   110 PKPEMSLPVKPGQGDSEVSSPFTPVADEDSVVFNKLTYLGCASVNAPRSE------------VEA 162

  Fly   521 NRTMVFLVGRCDL----------------RLISPD-RKQVLLYKDFKDVASCVHGQKSL---DHF 565
            .|.|..|..:|.:                ||:.|. ..::..|..:| :..||.|....   |.|
Mouse   163 LRMMSILRSQCQISLDVTLSVPNVSEGTVRLLDPQTNTEIANYPIYK-ILFCVRGHDGTPESDCF 226

  Fly   566 GIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQ--------KKKQDTQIF----SC 618
            .......|.:.:..:||:|:.:.....|:.:.|.||...|:|        .:..|:.||    |.
Mouse   227 AFTESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSL 291

  Fly   619 EHCPMLWYHKLCTDVEGL-----SEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQN 678
            |...        .|.:|.     .:|..|...||:     ..:::||   .|..:..|..:|.:.
Mouse   292 EIKE--------DDGKGYFSAVPKDKDRQCFKLRQ-----GIDKKIV---ICVQQTANKELAIER 340

  Fly   679 QFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDDIA 743
            .|.::|...........|:.|.     |.:.:...|.:..:....:..:....::..:..||.:.
Mouse   341 CFGLLLSPGKDVRNSDMHLLDL-----ESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVL 400

  Fly   744 VPSHN----LRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSK---PTAEQLKSPMMDIFIKVG 801
            ..:..    :.:::|           |..|...:.....||:.:   |.::  :|...:.|:|:
Mouse   401 FMTTAVDLVITEVQE-----------PVRFLLETKVRVCSPNERLFWPFSK--RSTTENFFLKL- 451

  Fly   802 NSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQT 866
               |:.:..:.......|..||.    |:||            ::|.:|         :|....:
Mouse   452 ---KQIKQKEKKNNADTLYEVVC----LESE------------SERERR---------KTTASPS 488

  Fly   867 IMLNRMETENAMLQARQNENELKRIKLDYEEIV---------PCDKQLIERWEQIIERNSTQIGN 922
            :.|.:..::::|:.:...::|    :.|.:|.:         .|.::::|.|.:::.:....:..
Mouse   489 VRLPQSGSQSSMIPSPPEDDE----EEDNDEPLLSGFGDVSKECAEKILETWGELLSKWHLNLSV 549

  Fly   923 KKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIF 987
            :  ||.|...:|:|||.:.||:||..||..|: |...|:         .|.:|:...:....||.
Mouse   550 R--PKQLSSLVRSGVPEALRGEVWQLLAGCHN-NDHLVE---------KYRILITKESPQDSAIT 602

  Fly   988 IDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLK 1052
            .|:.||||.|.::||..|.||.||:.:.||||:.|.|:|||||..|:..|||||..|..:|.:|.
Mouse   603 RDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFSVLV 667

  Fly  1053 HLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFP 1117
            .:||...:|..:..:.:....:.|||.||:::::||||.......:...:||:.|.||:|:::||
Mouse   668 KIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFP 732

  Fly  1118 LGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPK-----------M 1171
            |..|..:.|||..|...|||..|:.||...|..||..| ||..:.:.:..:||           |
Mouse   733 LYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLLLTD-FEGALKFFRVQLPKRYRSEENAKRLM 796

  Fly  1172 EHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSS 1236
            |..|..:|.:        |:|.:::.||:.::|:.......:|...||..:.|....:|:.....
Mouse   797 ELACNTKISQ--------KKLKKFEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDD 853

  Fly  1237 IA-QLETTRSSQQAQITTLQSQVQSLE----LTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLD 1296
            :| :|.|::.:.:..:...:.:..:|.    :|.|.|             ::..:|.||:.::..
Mouse   854 LAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKL-------------IDAEDEKRRLEEESA 905

  Fly  1297 DLDRQ-RRKPIFTERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQ-- 1358
            .|... ||:....|.:|.|:.|:   :|...::..:|:||.|     ||:.......|::||:
Mouse   906 QLKEMCRRELDKAESEIKKNSSI---IGDYKQICSQLSERLE-----KQQTANKVEIEKIRQKVD 962

  Fly  1359 ---------QQQHRLNGGGQSSNVGESGSPTPPSRPN-----RLLDNASARTVMQVKLDELK--- 1406
                     .::.|:.  |.||..|.|...|...:..     |.::...|:|.:|:...|.|
Mouse   963 DCDRCRDFFNKEGRVK--GISSAKGVSDEDTDEEKETLKNQLREMELELAQTKLQLVEAECKIQD 1025

  Fly  1407 LPEHVDKFVANIKSPLEVDSGVGTPLSPPSTASNSSG 1443
            |..|:...::.:::..:  :.....||...||:...|
Mouse  1026 LEHHLGLALSEVQAAKK--TWFNRTLSSIKTATGVQG 1060

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	61/294 (21%)
		DUF3350	831..880	CDD:463365	7/48 (15%)
		TBC	933..1152	CDD:214540	83/218 (38%)
		COG4372	<1190..>1353	CDD:443500	34/168 (20%)
Rabgap1	NP_666233.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101		28/117 (24%)
		PTB_Rab6GAP	140..268	CDD:269922	28/140 (20%)
		DUF3694	302..432	CDD:463599	22/153 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..520		8/54 (15%)
		TBC	558..767	CDD:214540	83/218 (38%)
		SMC_prok_B	784..>1027	CDD:274008	55/273 (20%)