Protein Alignment plx and Evi5l

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_001355721.1
• Gene: Evi5l / 213027
• MGIID: 2442167
• Length: 829
• Species: Mus musculus
• Alignment Length: 636
• Identity: 158/636 - (24%)
• Similarity: 272/636 - (42%)
• Gaps: 103/636 - (16%)

  Fly   819 LNSVVTPSKGLDSEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQA-- 881
            |.::.:|:...||.......:|...|....:..:.:..||          |.::|.:|.:|:|
Mouse    19 LPTMASPTLSPDSSSQEALSAPTCSPTSDSENLSPDELEL----------LAKLEEQNRLLEADS 73

  Fly   882 ----------RQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTG 936
                      |.:.:.|.........:...::.....|.:|  .|..:...::..|:|...||.|
Mouse    74 KSMRSMNGSRRNSGSSLVSSSSASSNLSHLEEDTWILWGRI--ANEWEEWRRRKEKLLKELIRKG 136

  Fly   937 VPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYK 1001
            :|...|..||..|.....|   ||..:        |..|||..:..:..|..|:.||:|.|:|:|
Mouse   137 IPHHFRAIVWQLLCSATDM---PVKNQ--------YSELLKMSSPCEKLIRRDIARTYPEHEFFK 190

  Fly  1002 DPLGLGQLSLFNLLKAYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLP 1066
            ....|||..|||::||||::|.|:|||||..||.|:||:...|..:|.:...||....:|..:.|
Mouse   191 GQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFVRLMQEYRLRELFKP 255

  Fly  1067 DMKKFQLQLYQLSRLVKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLE 1131
            .|.:..|.:||...::::.||||...........::||:.|.||:|.:.|||....||||:...|
Mouse   256 SMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYE 320

  Fly  1132 SSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYK 1196
            ..:::|:..:|||.|::.:|:..| .|.:..|.:.|:|....:|.::::           |..|:
Mouse   321 GLEIVFRVGLALLQVNQTELMQLD-MEGMSQYFQRVIPHQFDSCPDKLV-----------LKAYQ 373

  Fly  1197 VEYNV-----LQEEITTTNHHLEM-----LNREKTQNQHLEQQLQFAQSSIAQL-------ETTR 1244
            |:||.     |::|....... ||     :.|.:|:|:.|:|:::..:...|.|       :.||
Mouse   374 VKYNPKKMKRLEKEYAAMKSK-EMEEQIEIKRLRTENRLLKQRIETLEKESAALADRLIQGQVTR 437

  Fly  1245 SSQ-------QAQITTLQSQVQSLELTIQTLGRYVGQLVE--HNPDL----------ELPNEVRR 1290
            :.:       :.::..::.|..|....:|.....:.||.|  .||.|          ||.....|
Mouse   438 AQEAEENYVIKRELAVVRQQCSSTAEDLQKAQSTIRQLQEQQENPRLTEDFVAHLETELEQSRLR 502

  Fly  1291 MLQQLDDLDRQRRKPIFTERKIGKSVSVN--SHLGFPLKVLEELTERDELGSPQKQKKEKTPFFE 1353
            ..:.|..|...:.|.:..|::.......|  :.|...||.| ::.|.:.:.|.::.|.:    .:
Mouse   503 ETETLGALREMQDKVLDMEKRNSSLPDENNVARLQEELKAL-KVREGEAVASARELKLQ----LQ 562

  Fly  1354 QLRQQQQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDE 1404
            :|....|.|...||....:            |.:|:.......:|.|:|.|
Mouse   563 ELSDTWQAHLSRGGRWKES------------PRKLVLGELQDELMTVRLRE 601

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	8/48 (17%)
		TBC	933..1152	CDD:214540	78/218 (36%)
		COG4372	<1190..>1353	CDD:443500	42/200 (21%)
Evi5l	NP_001355721.1	TBC	133..341	CDD:214540	78/218 (36%)
		SMC_prok_B	<397..740	CDD:274008	44/222 (20%)