DRSC/TRiP Functional Genomics Resources

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Protein Alignment plx and Tbc1d4

DIOPT Version :9

Sequence 1:NP_001163511.1 Gene:plx / 40704 FlyBaseID:FBgn0261261 Length:1572 Species:Drosophila melanogaster
Sequence 2:XP_006518822.1 Gene:Tbc1d4 / 210789 MGIID:2429660 Length:1307 Species:Mus musculus


Alignment Length:1309 Identity:412/1309 - (31%)
Similarity:611/1309 - (46%) Gaps:327/1309 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   194 MAELMHQMRDPAHTLGGSVGS-------------------IPQTLIGGGGGSHGNSNGALNGIHA 239
            |||:..:.:.|.   .|..|:                   .|...:|||.||     ||:.    
Mouse    59 MAEIRRRSQKPD---AGGCGAPAAREVILVLSAPFLRCVPAPGAGVGGGAGS-----GAVQ---- 111

  Fly   240 TPATNLKMSEAMRNAQH------------------DTSPNPVSSKMKASKSYTHGLSSSSGTVNI 286
             |.|.:.:.|  ..|||                  ...|:...|:|..   :....:..:...::
Mouse   112 -PNTGVFIFE--HKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMAC---HVFRATDPNQVPDV 170

  Fly   287 PTSTSAQSNLSLLADISPN--------HTHFFEVMYVGKIRVSQKRVPNTFIDDALPKFKAYDAQ 343
            .:|....|..::..|..|:        ::..|||:|.|::.|:.|:.|::.|||...||..::.|
Mouse   171 ISSIRQLSKAAMKEDSKPSKDNEDAFYNSQKFEVLYCGRVIVTHKKAPSSLIDDCKDKFSLHEQQ 235

  Fly   344 RLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTG 408
            ||:|...|......|.||                    .|.|.....|||...:|...|      
Mouse   236 RLKLQGERGGDPGDEMGV--------------------LEVESPVSPDDSLPEKADGTV------ 274

  Fly   409 AEEGAAPRPLEDNKENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIV------N 467
                            .||...|.|.....:         .|||..|:|::..|..|:      .
Mouse   275 ----------------NSPRALPSLASLPAL---------ASQPALASSRVCFPERILEDCGFDE 314

  Fly   468 KQPTPPRDQGVGTGTASASAGPSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRCD 532
            :|....|...| ||...     .::|.|..... |::|..||.....|...|:||||:|.|||.:
Mouse   315 QQEFRSRCSSV-TGVMQ-----KKVHENNQKTQ-PRRRHASAPSHVQPSDSEKNRTMLFQVGRFE 372

  Fly   533 LRLISPDRKQVLLYKDFKDVASCVHGQKSLDHFGIICRELNNDG---YIGYVFKCQSEHVCDDIV 594
            :.|||||.|.|:|.|:|||::||..|.|.:||||.||||....|   ||.|||:|.:|.:.|:::
Mouse   373 INLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCANESLVDEVM 437

  Fly   595 AAIAQAFDTCAEQKKKQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEI 659
            ..:.|||.|.|..:..: |||..||.|||...||||..:|||...:.:.:|.|.:.:|:|:||..
Mouse   438 LTLKQAFSTAAALQSAK-TQIKLCETCPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQAD 501

  Fly   660 VWAKFCGSEKTNSPVA--EQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYL------GG-- 714
            ::.:.    :...|::  |:|:.:::.||..||::|:.||| ..|..:...|..:      ||  
Mouse   502 IFERV----QKMKPISDQEENELVILHLRQLCEAKQRTHVH-IGEGPAIISNSTIPENVTSGGRF 561

  Fly   715 --STIFMKAKRSLTNSFDNLLKRKPSK-------DDIAVPSHNL---RDIREGSAEPLGTQSPPE 767
              ..:..|||||||:|.:|:..|..::       .|....:::|   :|...|.:.| ||  ||.
Mouse   562 KLDVLKNKAKRSLTSSLENIFSRGANRMRGRLGSMDSFERANSLASEKDFSPGDSPP-GT--PPA 623

  Fly   768 G------------------FRSRSNTVGASPSSK--------PTAEQLKSPMM------------ 794
            .                  ||.|::|....|||.        ..|..|:||::            
Mouse   624 SPLSSAWHAFPEEDSDSPQFRRRAHTFSHPPSSSRRKLNLQDGKAHGLRSPLLRQSSSEQCSIVP 688

  Fly   795 -----------------------------DIFIK--VGNSPK---------------EAETHQG- 812
                                         ..|:|  ..||.:               |:...:| 
Mouse   689 SARRMYKESNSSCSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGR 753

  Fly   813 ------------------------SWRQAILNSVVTP-----------SKGLDSE--VPTEFLSP 840
                                    ||||.|...|.:|           ..|||..  :|...|||
Mouse   754 KRTSSTCSNESLNAGGTPVTPRRVSWRQRIFLRVASPVNKSPSAMQQQKDGLDRTELLPLSPLSP 818

  Fly   841 MRKPAK--------------RGKRDAAELRELWRTAIRQTIMLNRMETENAML-QARQNENELKR 890
            ..:...              ..|:.:.||:.||:.||.|.|:|.|||.||..| :||::|.:.::
Mouse   819 TMEEEPLIIFLSGDEDTEKVEEKKKSKELKSLWKKAIHQQILLLRMEKENQKLEEARRDELQSRK 883

  Fly   891 IKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSM 955
            :||||||:..|.|:::..|::.:....|:|  :.|.:.:..:::.|||:|:||::|.|||.|:.:
Mouse   884 VKLDYEEVGTCQKEILIAWDKKLLNCRTKI--RCDMEDIHTSLKEGVPKSRRGEIWQFLALQYRL 946

  Fly   956 NTAPVDTKRFPNFNTP----YHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLK 1016
            .      .|.||.:.|    |..|||.||..||||.:|||||||.|.::...||.||||||||||
Mouse   947 R------HRLPNKHQPPDTSYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGAGQLSLFNLLK 1005

  Fly  1017 AYSILDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRL 1081
            |||:||.|:|||||:.|:.||||||..|..:|::||.||:....|.:|.|||...|:|:||||||
Mouse  1006 AYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRL 1070

  Fly  1082 VKDHLPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSV 1146
            :.|:..:||..|::|::||:||||||.||:|:|||||||||||||::||:.::||||.|::|||.
Mouse  1071 LHDYHRELYNHLEENEISPSLYAAPWFLTLFASQFPLGFVARVFDIIFLQGTEVIFKVALSLLSS 1135

  Fly  1147 HKQQLLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYNVLQEEITTT-- 1209
            .:..::..:|||.|:::||:.:|.|..|.||:|:..||.|||.|||..|:|||:|||:|:..:  
Mouse  1136 QEALIMECENFENIVEFLKSTLPDMNTTEMEKIITQVFEMDISKQLHAYEVEYHVLQDELLESSY 1200

  Fly  1210 ----NHHLEML----NREKTQNQHLEQQLQFAQSSIAQLE-------TTRSSQQAQITTLQSQVQ 1259
                |..||.|    |:.|.||..|.::||.|.:.|..||       |..:..:|.|.||:....
Mouse  1201 ACEDNESLEKLERANNQLKRQNMDLLEKLQVAHAKIQALESNLETLLTRETKMKALIRTLEQDKM 1265

  Fly  1260 SLELTIQTL 1268
            :.:.|::.:
Mouse  1266 AYQKTVEQI 1274

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
plxNP_001163511.1 PTB_TBC1D1_like 301..601 CDD:269967 96/316 (30%)
DUF3350 835..880 CDD:288663 19/59 (32%)
TBC 933..1152 CDD:214540 121/222 (55%)
RILP-like <1176..1267 CDD:304877 40/107 (37%)
Tbc1d4XP_006518822.1 PTB 31..190 CDD:214675 27/148 (18%)
PTB_TBC1D1_like 193..444 CDD:269967 94/308 (31%)
DUF3350 814..872 CDD:371748 18/57 (32%)
TBC 927..1141 CDD:214540 121/219 (55%)
PTZ00440 <1141..>1272 CDD:240419 49/130 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 250 1.000 Domainoid score I2103
eggNOG 1 0.900 - - E1_KOG4436
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 569 1.000 Inparanoid score I1058
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D164786at33208
OrthoFinder 1 1.000 - - FOG0003414
OrthoInspector 1 1.000 - - otm42532
orthoMCL 1 0.900 - - OOG6_105859
Panther 1 1.100 - - O PTHR22957
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R541
SonicParanoid 1 1.000 - - X2765
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.860

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