Protein Alignment plx and tbc-12

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_508458.1
• Gene: tbc-12 / 180556
• WormBaseID: WBGene00044061
• Length: 614
• Species: Caenorhabditis elegans
• Alignment Length: 231
• Identity: 52/231 - (22%)
• Similarity: 92/231 - (39%)
• Gaps: 49/231 - (21%)

  Fly   103 DVSGFWHSLLVKLINEMFGFSHKTFDPAAKVKNKNAISALFEEFL-AAEKPDRSTAYEYICV--- 163
            :|..|:..|:..:|| ..|.:...::.....||...:.:|..... ::.:.|.::::..|.:
 Worm   489 NVPNFFVYLVTSVIN-FLGINDLFYEIRLLQKNSQILYSLENTTTKSSARRDWASSHTQIQIADH 552

  Fly   164 -MYIKYLQQMNLHAELELFAAEKIAHPHEYQQEGSSYWKEECLALLKAADKC---TNN------- 217
             |.:.|:..::....|.::   .||....||:|.|:  ||.|       ||.   ||.
 Worm   553 DMLLHYITDVDYEHSLLIW---HIATELCYQEEDSA--KENC-------DKSEYHTNRKISKIIS 605

  Fly   218 -----------RLRNNLLTIGKRLFNNTTANISKQTEAFFAILTYIDLCDNPVTA--EVWTGLRK 269
                       :|.:.:..|||..|.:|.|    :.:.||..:..|....|...|  |:.:....
 Worm   606 DYMMYLLIMQPKLMSEVAGIGKIRFRDTLA----EADRFFKKMGIIRDSRNVKLASKEILSADTS 666

  Fly   270 ICKRVIE--HGNEVLFFANNENFDENLKSALKVFGE 303
            |..|.::  |...|||.|:  :..:.|:...|.|||
 Worm   667 IEPREVKGNHSKSVLFEAS--SLAKELQRVEKNFGE 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	3/3 (100%)
		DUF3350	831..880	CDD:463365
		TBC	933..1152	CDD:214540
		COG4372	<1190..>1353	CDD:443500
tbc-12	NP_508458.1	TBC	295..521	CDD:214540	7/32 (22%)