Protein Alignment plx and tbc-11

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: NP_508178.2
• Gene: tbc-11 / 180444
• WormBaseID: WBGene00018075
• Length: 934
• Species: Caenorhabditis elegans
• Alignment Length: 989
• Identity: 215/989 - (21%)
• Similarity: 382/989 - (38%)
• Gaps: 239/989 - (24%)

  Fly   546 YKDFKDVASCVHGQKSLDHFGIICREL-NNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKK 609
            :|||.:|....:.|    :.|  |.:| |||.              |:.:.|:.:..|   |||.
 Worm     4 FKDFTEVTQFTNVQ----YLG--CSQLVNNDN--------------DNEMKALMKVLD---EQKG 45

  Fly   610 KQDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFC--GSEKTNS 672
            .|...:      .::..|.:...|:         ||..:.:.||  ...:|..:||  |...|:.
 Worm    46 AQTINV------TLVVPHNISGTVK---------LIDAQGKVLS--SFSLVNIRFCIRGESSTSQ 93

  Fly   673 ------------PVAEQNQFLMMLLRAHCESRQQRHVHDT--AENRSEFLNQY---LGGSTIFMK 720
                        .|.|.|.         .:...|.||..|  ||..::.|..:   .....:..:
 Worm    94 NNCFGISFTHKISVGEHNS---------SDILHQCHVFRTSKAETAAKALYSFSYAFSNKNVSSE 149

  Fly   721 AKRSLTNSFDNLLKRKPSKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSKPT 785
            :.| |...|:::|:.|.:...:..||..|.....|.            |:.|.:      ..|..
 Worm   150 SNR-LEFQFESILEVKENDGTVEKPSWKLCPQHNGV------------FKVRRD------REKKI 195

  Fly   786 AEQLK---------SPMMDIFIKVGNSPKEAETH------------------QGSWRQAILNSVV 823
            ..||:         .....:.:..|.:.:.::..                  :.:|...:....|
 Worm   196 VVQLRQIDGFLLNIKKCFGMLLAAGRNLRHSDLQLLEMDRNATGTDSAVFVIEANWDPRVHMFEV 260

  Fly   824 TPSKGLDSEVP---------------TEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNR-- 871
                 |::|.|               :|...|:|...:...|...|....::|.  ||::...
 Worm   261 -----LNTETPRDTRVFMTVAIDVIVSEISEPIRFSMEAMSRVFHEHERFYKTP--QTVVSEEFT 318

  Fly   872 METENAMLQARQNENELKRIKLDYEE--------------------IVP-------CDKQL---- 905
            :..|.:..|:..|:.:|..|.|:.:.                    :.|       ||:.|
 Worm   319 LVLEKSCDQSDPNDRKLTFISLESDSDRKRSKQNLGKSPSRMPTQLLHPTGDDESDCDEPLLSGS 383

  Fly   906 -----------IERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAP 959
                       :|.|:|:|| |..|..::  |:.:...:..|:|...||.||..|:   ::....
 Worm   384 GKVSQECKEEHLEMWDQLIE-NWDQQSDR--PQKISELVLDGIPDKLRGRVWQLLS---NVRILA 442

  Fly   960 VDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPE 1024
            :|.   |:....||:.|......:..|..|:.||||.|.::|:..|.||.||:.:.|.||:.|.|
 Worm   443 IDQ---PDLVEKYHIFLSQPCPSEQVIMRDIHRTFPAHDYFKESQGKGQQSLYKISKVYSLYDEE 504

  Fly  1025 LGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDL 1089
            :.|||||.|:...||||..|..:|..|..:||...:|..:........|:.:||:.|:||::|||
 Worm   505 VSYCQGLSFLAASLLLHMPEEQAFCTLVKIMFNYGLRDLFKLGFDNLHLRFFQLTALLKDYIPDL 569

  Fly  1090 YVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAK 1154
            ...|:...:...:||:.|.||:|:::|||..|..:.||...:..:.||..::|||...|..||..
 Worm   570 SHHLEHIGIETHMYASQWFLTLFTAKFPLQMVFFILDLFLSQGMNTIFHISLALLDDAKTDLLQL 634

  Fly  1155 DNFEEIMDYLKTVVPKMEHT-----CMEQIMKLV-FSMDIGKQLAEYKVEYNVLQEEITTTNHHL 1213
            | ||..:.|.:..:|:...|     |:  |.|.| |.::..| |..|:.||..: :|:...|..
 Worm   635 D-FEGTLKYFRVSLPRKYRTEASTKCL--IHKAVKFRLNHSK-LEVYENEYKRI-KELERENED- 693

  Fly  1214 EMLNREKTQNQHLEQQLQFAQSS---IAQLETTRSSQQAQITTLQSQVQSLELTIQTLGRYVGQL 1275
            .:|..||...:|....|:..:.:   ..:|.|::...:.::...:.|:::....|:.|.|....:
 Worm   694 PVLRMEKEIGRHQANTLRLERENDDLAHELVTSKIELRRKLDVAEDQIETSANAIERLTRQNMDI 758

  Fly  1276 VEHNPDL-----ELPNEVRRMLQQLDDLDRQRR------KPIFTERKIGKSVSVNSHLGFPLK-V 1328
            :|.|.:|     ::....||.:.:|::...:..      |.:|:||. .::.:...|.....| :
 Worm   759 LEENKNLMREYEQIKEMYRRDVLRLEENGSRAEKLLAEYKKLFSERS-KRAENEREHFEVQKKAI 822

  Fly  1329 LEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNAS 1393
            :..:::.|:.. |...:.||                    ..|.|..:.:||.|....:|.:...
 Worm   823 IARISDCDKCW-PAVCEWEK--------------------NRSPVHSASTPTGPDLLTKLEERED 866

  Fly  1394 ARTVMQVKLDELKL 1407
            ....:::.|.:.||
 Worm   867 HIKNLEIDLAQTKL 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	13/55 (24%)
		DUF3350	831..880	CDD:463365	11/65 (17%)
		TBC	933..1152	CDD:214540	74/218 (34%)
		COG4372	<1190..>1353	CDD:443500	34/177 (19%)
tbc-11	NP_508178.2	PH-like	11..147	CDD:473070	35/184 (19%)
		DUF3694	183..293	CDD:463599	15/132 (11%)
		TBC	419..632	CDD:214540	74/218 (34%)
		rad50	<676..>919	CDD:129694	41/229 (18%)
		PspA	<685..>796	CDD:441447	19/111 (17%)