Protein Alignment plx and Evi5

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_006534839.1
• Gene: Evi5 / 14020
• MGIID: 104736
• Length: 869
• Species: Mus musculus
• Alignment Length: 690
• Identity: 161/690 - (23%)
• Similarity: 295/690 - (42%)
• Gaps: 151/690 - (21%)

  Fly   786 AEQLKSPMMDIFIKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLS-PMRKPAKRGK 849
            ||:|.|.:..:        |...:|..|   .:.:.|.:||..|.:...:..|| |.:.|:...|
Mouse    24 AEKLSSTLSWV--------KNTVSHTVS---QMASQVASPSASLHTTSSSTTLSTPTQSPSSPSK 77

  Fly   850 RDAAELRELWRTAIRQTIMLNRMETENAMLQ-----------ARQN-----------ENELKRIK 892
            ....:|.           :|.::|.:|.:::           :|:|           .:.|..::
Mouse    78 LSPDDLE-----------LLAKLEEQNRLIETDSKSLRSVNGSRRNSGSSLVSSSSASSNLSHLE 131

  Fly   893 LDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNT 957
               |:......:::..|:.:         .||..|.:...:|.|:|...|..||..|....||
Mouse   132 ---EDSWILWGRIVNEWDDV---------RKKKEKQVKELVRKGIPHHFRAIVWQLLCNAQSM-- 182

  Fly   958 APVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILD 1022
                     .....|..|||..:..:..|..|:.||:|.|.|:|:...|||..|||::||||::|
Mouse   183 ---------TIKDQYSELLKMTSPCEKLIRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVD 238

  Fly  1023 PELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLP 1087
            .|:|||||..||.|:||:...|..:|.:...||....:|..:.|.|.:..|.:||...:::::||
Mouse   239 REVGYCQGSAFIVGLLLMQMPEEEAFCVFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEYLP 303

  Fly  1088 DLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLL 1152
            :|:|.........::||:.|.||:|.:.|||....|:||:...|..:::|:..:|||.:::.:|:
Mouse   304 ELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELM 368

  Fly  1153 AKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIGKQLAEYKVEYN-----VLQEEITT--TN 1210
            ..| .|.::.:.:.|:|.......|::::           :.|:|:||     .|::|.||  |.
Mouse   369 QLD-MEGMLQHFQKVIPHQFDGGPEKLIQ-----------SAYQVKYNSKKMKKLEKEYTTIKTK 421

  Fly  1211 HHLEM--LNREKTQNQHLEQQLQFAQSSIAQL-------ETTRSSQ-------QAQITTLQSQVQ 1259
            ...|.  :.|.:|:|:.|:|:::..:...|.|       :.||:.:       :.::.|::.|..
Mouse   422 EMEEQGEIKRLRTENRLLKQRIETLEKESASLADRLIQGQVTRAQEAEENYLIKRELATIKQQTD 486

  Fly  1260 SLELTIQTLGRYVGQLVEH----------NPDLELPNEVRRMLQQLDDLDRQ------RRKPIFT 1308
            :....::.....:.:|..|          |.|..|..|...:..:|.:.:.|      :.|.:..
Mouse   487 AARAKLEQAESTIRELRHHRHWHKCSSTYNEDFVLQLEKELVQARLSEAESQCALKEMQDKVLDI 551

  Fly  1309 ERKIGKSVSVNSHLGFPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQ-------QQQHRLNG 1366
            |:|.......|:        :..|.|  ||.:.:.::.|.....::||||       .|:|....
Mouse   552 EKKNNSFPDENN--------IARLQE--ELIAVKLREAEAIMGLKELRQQVRTLEEHWQRHLART 606

  Fly  1367 GGQSSNVGESGSPTPPSR--PNRLLDNASARTVMQVKLDE 1404
            .|:..:        ||.:  .|.|.|.     :|.::|.|
Mouse   607 SGRWKD--------PPKKNAVNELQDE-----LMSIRLRE 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	9/49 (18%)
		TBC	933..1152	CDD:214540	74/218 (34%)
		COG4372	<1190..>1353	CDD:443500	38/201 (19%)
Evi5	XP_006534839.1	TBC	160..368	CDD:214540	74/218 (34%)
		Smc	<406..>732	CDD:440809	49/251 (20%)