DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment plx and SGSM1

DIOPT Version :9

Sequence 1:	NP_001163511.1	Gene:	plx / 40704	FlyBaseID:	FBgn0261261	Length:	1572	Species:	Drosophila melanogaster
Sequence 2:	NP_001035037.1	Gene:	SGSM1 / 129049	HGNCID:	29410	Length:	1148	Species:	Homo sapiens

Alignment Length:	1199	Identity:	229/1199 - (19%)
Similarity:	389/1199 - (32%)	Gaps:	404/1199 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 RHTLTASTSYGSLSSSAACAYQLQLQQSAEASAEQPQNFMEFQGPITGLVY----LLKDPKDPLL 181
            ||   :|.|.....|.:|..|...|.|::.|:                |:|    :|..|:|.:.
Human   227 RH---SSGSMDDRPSLSARDYVESLHQNSRAT----------------LLYGKNNVLVQPRDDME 272

  Fly   182 HI--YLFECEAVEEMAELMHQMRDPAHTLGGSVGSIPQTLIGGGGGSHGNSNGALNGIHATPATN 244
            .:  ||    ::.:.|::|.....|...:.||||.:...                ..::...|..
Human   273 AVPGYL----SLHQTADVMTLKWTPNQLMNGSVGDLDYE----------------KSVYWDYAMT 317

  Fly   245 LKMSEAMRNAQHDTSPNPVSSKMKASKSYTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTHF 309
            :::.|.:                   ..:.|....|.|||
Human   318 IRLEEIV-------------------YLHCHQQVDSGGTV------------------------- 338

  Fly   310 FEVMYVGKIRVSQ---KRVPNTFIDDALPKFKAYDAQRLRLLQNRKM-------SLSSEGGVG-- 362
                    :.|||   :|.|..|     || ..:..|.|..|:|..:       .|.|:.|.|
Human   339 --------VLVSQDGIQRPPFRF-----PK-GGHLLQFLSCLENGLLPHGQLDPPLWSQRGKGKV 389

  Fly   363 ----IEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKPLVQLQLTGAE-EGAAPRPL-EDN 421
                .:..|..|.:|....::|:|..:.              :.::...|.: |..||..| ..:
Human   390 FPKLRKRSPQGSAESTSSDKDDDEATDY--------------VFRIIYPGMQSEFVAPDFLGSTS 440

  Fly   422 KENKSPEKRPLLRGQSQIELGHKEHSDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVGTGTASAS 486
            ..:..|....:..|:|.:.:..     |||...|......|.....:||..|:|    ....|.|
Human   441 SVSVGPAWMMVPAGRSMLVVAR-----GSQWEPARWDTTLPTPSPKEQPPMPQD----LMDVSVS 496

  Fly   487 AGPSQLHPNYAMDNIPKQ-----------RDRSASQGCIPPYVEQNRTMVFLVGRCDLRLISPDR 540
            ..||...|:      |::           .|.|::.||       |..      |..|:|:..:.
Human   497 NLPSLWQPS------PRKSSCSSCSQSGSADGSSTNGC-------NHE------RAPLKLLCDNM 542

  Fly   541 KQVLLYKDFKD-VASCVHGQKSLDHFG------IICRELNNDGYIGYVFKCQSEHVCDD------ 592
            |..:|.:.|.. :|.|.|......|..      |:..:|..|...|...:...:::.|.
Human   543 KYQILSRAFYGWLAYCRHLSTVRTHLSALVNHMIVSPDLPCDAGQGLTARIWEQYLHDSTSYEEQ 607

  Fly   593 ----------IVAAIAQA----------FDTCAEQKKKQDTQIFSCEHCPML-WYHKLCTDVEGL 636
                      |...|.:|          |.....::|:.|.||.:|....|. |..  |..:...
Human   608 ELLRLIYYGGIQPEIRKAVWPFLLGHYQFGMTETERKEVDEQIHACYAQTMAEWLG--CEAIVRQ 670

  Fly   637 SEKKTQAL-----------------ILRRIETLSDDEQEIVWAKFCGSEKTNSPVAEQNQFLMML 684
            .|:::.|.                 :|.|..|:|::.     ::.|.|.:.|
Human   671 RERESHAAALAKCSSGASLDSHLHRMLHRDSTISNES-----SQSCSSGRQN------------- 717

  Fly   685 LRAHCESRQQRHVHDT--------AENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKPSKDD 741
            :|.|.:|.....|.::        ||.|.|             :.:..:.|.  ||:....|.|.
Human   718 IRLHSDSSSSTQVFESVDEVEQVEAEGRLE-------------EKQPKIPNG--NLVNGTCSPDS 767

  Fly   742 IAVPSHNLRD-IREGSAEPLGTQ--------SPPEGFRSRSNTVGASPSSKPTAEQLKSPMMDIF 797
            ....|||... :.|.|...|.|:        :.|...|.|..:|....||:.|..|.::|..::.
Human   768 GHPSSHNFSSGLSEHSEPSLSTEDSVLDAQRNTPTVLRPRDGSVDDRQSSEATTSQDEAPREELA 832

  Fly   798 IKVGNSPKEAETHQGSWRQAILNSVVTPSKGLDSEVPTEFLS-----PMRKPAKRGKRDAAELRE 857
            :                 |..|.|.:..::.:|     ||:|     .|..|.|..     .:.|
Human   833 V-----------------QDSLESDLLANESMD-----EFMSITGSLDMALPEKDD-----VVME 870

  Fly   858 LWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDYEEIVPCDKQLIERWEQIIERNSTQIGN 922
            .||::          |||             |..:.|.|:.:..:.::...:..:.....|...|
Human   871 GWRSS----------ETE-------------KHGQADSEDNLSEEPEMESLFPALASLAVTTSAN 912

  Fly   923 KKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIF 987
            :..|     ...:||         |:..|                       ||...|.:.|.|.
Human   913 EVSP-----VSSSGV---------TYSPE-----------------------LLDLYTVNLHRIE 940

  Fly   988 IDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPELGYCQGL-GFICGVLLLHCDEANSFQLL 1051
            .|:.|...|: :|..|..|.:|.  |::.:|.....|:||.||: ..:..:|::..|||.:|...
Human   941 KDVQRCDRNY-WYFTPANLEKLR--NIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALAFSCF 1002

  Fly  1052 KHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLYVWLDQN-DVSPTLYAAPWILTVFSSQ 1115
            ..||.|.|....:...|......:..|.:::...|.:|   :.|| |.:...:...|.|..|..:
Human  1003 TELMKRMNQNFPHGGAMDTHFANMRSLIQILDSELFEL---MHQNGDYTHFYFCYRWFLLDFKRE 1064

  Fly  1116 FPLGFVARVFDLLFL-----------ESSDVIFKFAIALLSVHKQQLLAKDNFEEIMDYLKTVVP 1169
            .       |:|.:||           .|:..:...|:||:.|::..:|  :|..:..|.:|....
Human  1065 L-------VYDDVFLVWETIWAAKHVSSAHYVLFIALALVEVYRDIIL--ENNMDFTDIIKFFNE 1120

  Fly  1170 KMEHTCMEQIMKLVFSMDIGKQLAEYKVE 1198
            ..|....:|::||...:       .|||:
Human  1121 MAERHNTKQVLKLARDL-------VYKVQ 1142

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	67/361 (19%)
		DUF3350	835..880	CDD:288663	12/49 (24%)
		TBC	933..1152	CDD:214540	51/231 (22%)
		RILP-like	<1176..1267	CDD:304877	6/23 (26%)
SGSM1	NP_001035037.1	RUN	44..188	CDD:280855
		PH_RUTBC	254..425	CDD:275431	43/278 (15%)
		Important for interaction with RAB9A and RAB9B. /evidence=ECO:0000250\|UniProtKB:Q8BPQ7	256..297		10/44 (23%)
		Required for interaction with RAP family members	301..350		13/116 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	377..411		7/33 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	700..830		34/162 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	871..894		8/45 (18%)
		TBC	<936..1105	CDD:214540	44/181 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910