Protein Alignment plx and Evi5

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_061506770.1
• Gene: Evi5 / 1273609
• VectorBaseID: AGAMI1_013251
• Length: 803
• Species: Anopheles gambiae
• Alignment Length: 636
• Identity: 157/636 - (24%)
• Similarity: 280/636 - (44%)
• Gaps: 110/636 - (17%)

  Fly   839 SPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQA-------------RQNENELKR 890
            |.:|.|.......::||.           :|.::|..|.::::             .:..::..:
Mosquito    11 SSLRNPDMTETLPSSELS-----------LLAKLEAANKLIESDSKSLNSLQSSAHSRKSSDTSQ 64

  Fly   891 IKLDYEEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSM 955
            |.|:.......::.:...|..|:  ...:...|:....:...:|.|:|...|..||..|.
Mosquito    65 ISLNSGASSVGEEDVWSTWASIV--TDWEASQKRKGPTVKELVRKGIPHHFRAIVWQLLC----- 122

  Fly   956 NTAPVDTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSI 1020
            ..:..|.|::..:       :|..:..:..|..|:.||:|.|.|:|:..||||.:|||::||||:
Mosquito   123 GASDADKKQYAEY-------IKATSACEKVIRRDIARTYPEHDFFKEKDGLGQEALFNVMKAYSL 180

  Fly  1021 LDPELGYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDH 1085
            .|.|:|||||.|||.|:||:...|..:|.:|..:|.:..||..:.|.|.:..|.:|||..:|::.
Mosquito   181 HDREVGYCQGSGFIVGLLLMQMPEEEAFAVLVQIMQQYRMRDMFKPSMAELGLCMYQLENIVQEQ 245

  Fly  1086 LPDLYVWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQ 1150
            :|:|::.........::||:.|.||::::...|....|:.|:...|..:.|||.|||||::.|..
Mosquito   246 IPELHLHFQSQSFQTSMYASSWFLTLYTTALNLTLSCRIMDVFLSEGMEFIFKVAIALLTIGKDT 310

  Fly  1151 LLAKDNFEEIMDYLKTVVPKMEHTCMEQIMKLVFSMDIG-KQLAEYKVEYNVL----QEEITTTN 1210
            ||:.| .|.::.|.:..:|:......:.:..|.|.:.|. |::.:.:.||..|    |||:.
Mosquito   311 LLSLD-MEAMLKYFQKELPQKVENDADGLFNLAFQVKINTKRMKKMEKEYADLRKKEQEEMV--- 371

  Fly  1211 HHLEMLNRE----KTQNQHLE-------QQLQFAQSSIAQLETTRSSQQAQITTLQ--------- 1255
             .|..|..|    |.:|:.||       .:|...|.|.|:.|.|..:.|:::..|:
Mosquito   372 -ELRRLRSENRLLKKRNELLEAESAELADRLVRGQVSRAEEEETSYAIQSELLALRRAHLEVSHQ 435

  Fly  1256 -----SQVQSLELTIQTLGRYVGQLVEHNPDLELPNEVRRM------------LQQLDDLDRQRR 1303
                 .:|::|.|.:|          |:|||..|.:...|.            |:|.|::.....
Mosquito   436 LENANEEVRALSLRLQ----------ENNPDNSLESNNSRQNSFDELIMKEEALKQRDEMVSCLL 490

  Fly  1304 KPIFTERK-IGKSVSVNSHLGFPLKVLEELTER--------------DELGSPQKQKKEKTPFFE 1353
            :.:...|: :.:|..|..:|...::.|||..:|              |||.:.:.::.|.:...:
Mosquito   491 EELVKVRQGLAESEDVIRNLKTKIQELEEDKKRLRETTTDNSVAHLQDELIASKLREAEASLSLK 555

  Fly  1354 QLRQQQQQHRLNGGGQSSNVGESGSPTPPSRPNRLLDNASARTVMQVKLDE 1404
            .|:|:.|:.......|.|......:.:..|...:||...|.|:....||:|
Mosquito   556 DLKQRVQELSTQWQRQLSEQRNDPAQSQDSGAKKLLFWESGRSQDLQKLEE 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967
		DUF3350	831..880	CDD:463365	8/40 (20%)
		TBC	933..1152	CDD:214540	75/218 (34%)
		COG4372	<1190..>1353	CDD:443500	47/218 (22%)
Evi5	XP_061506770.1	None