Protein Alignment plx and GAPcenA

DIOPT Version :10

• Sequence 1: NP_001163511.1
• Gene: plx / 40704
• FlyBaseID: FBgn0261261
• Length: 1572
• Species: Drosophila melanogaster
• Sequence 2: XP_061504472.1
• Gene: GAPcenA / 1269845
• VectorBaseID: AGAMI1_004392
• Length: 1435
• Species: Anopheles gambiae
• Alignment Length: 1658
• Identity: 345/1658 - (20%)
• Similarity: 562/1658 - (33%)
• Gaps: 531/1658 - (32%)

  Fly    31 DIRSTESYTKLSVGIENGIL---ESYNSDFELQFSHPLKHIVGMCRIIHKPQAKSIGNG------ 86
            |.||:.|.:||    |..::   :|.:.|..     |::...       .|.|.|.|.|
Mosquito    41 DSRSSSSSSKL----EKNVVHHPDSTSGDHS-----PVQQPT-------TPVAASSGGGADTPGP 89

  Fly    87 ----FLQLKSSAGQTSSSS-AVASSMGGAASSSLTGNGLRHTL----TASTSYGSLSSS------ 136
                .|.:|||...|:|.. .:.......|.....|:|..|.|    ..||.......|
Mosquito    90 KSEDSLSIKSSDSVTTSGEYEIVPEAPSPAEELADGSGGVHRLGRDPIRSTEANGCGRSDGGGDI 154

  Fly   137 ----AACAYQLQLQQS--------AEASAEQPQNFMEFQGPITGLVYLLKDPKDPLLHI----YL 185
                |.|......|:.        .|.:||:..:.......:|.:        .|:|:|    .:
Mosquito   155 GADLAECIADDGEQEKRGAGEGGCKEEAAEEGVSKRPEGKKLTAI--------SPILNIEGSGNM 211

  Fly   186 FECEAVEEMAELMHQMR---------DPAHTL-------------------GGSVGS----IPQT 218
            .:.|  :.|.|::|::.         ||:.:.                   ||:..|    :|.:
Mosquito   212 MDLE--KNMNEVIHELEEERTLSGASDPSASNKATPVAVRSPEKHGSTAQDGGTSASKKPQVPTS 274

  Fly   219 L----------IGGGGGSHGNSNGAL---NGIHATPATNLKMSEAMRNAQHDTSPNPVSSKMKAS 270
            |          .||||||...:..||   :|:...........:.:     |:|  |::.|....
Mosquito   275 LRLGLQSLGANFGGGGGSTDTTPNALLSPDGLIGRGVGQSVFYDCL-----DSS--PLTEKKDDM 332

  Fly   271 KSYTHGLSSSSGTVNIPTSTSAQSNLSLLADISPNHTHFFEVMYVGKIRVSQKRVPNTFIDDALP 335
            |....|....:|      :.:|......|:||..:.|.|..|.|:|..|::            .|
Mosquito   333 KPVGGGGGGGAG------AAAAGETDEELSDIDQDCTIFSGVTYLGASRIN------------AP 379

  Fly   336 KFKAYDAQRLRLLQNRKMSLSSEGGVGIEAKPSSSLKSHDLKEEDEEEQEQHKGHDDSQDSQAKP 400
            |     ::|..|.:..:|:....||.|....|                 |...|.|       .|
Mosquito   380 K-----SEREILQKVTEMNAGGGGGAGAGVGP-----------------EPGSGSD-------SP 415

  Fly   401 L---VQLQLTGAEEGAAPRPLEDNKENKSPEKRPLLR-----------------------GQSQI 439
            |   |.:.:....||..  .|.|.:.|.......:||                       |:||.
Mosquito   416 LGLKVSVSIPTCSEGLV--VLYDCESNAVVATYEVLRILFFARGPVGSPDQACFAFTWSHGESQE 478

  Fly   440 ELGHKEH----------SDGSQPLAANSQLEAPNVIVNKQPTPPRDQGVG---TGTASASAG--- 488
            ...|:.|          :..|...:...|...|..|.....|...:.||.   :...|.:||
Mosquito   479 TAVHQCHVFRCNIPEAVTQVSTCFSKAFQRVLPPSIPASMTTSLAESGVNVMLSSVTSDTAGNPI 543

  Fly   489 PSQLHPNYAMDNIPKQRDRSASQGCIPPYVEQNRTMVFLVGRC--------DLRLISPDRKQVLL 545
            .|.:: .:|:....|:::|::|...:|..|:.:..:     ||        .:|.:..||...||
Mosquito   544 QSAMY-EFAVSLEIKEKERNSSYVTVPRDVKSSFRL-----RCRTDKEVCITVRQVPSDRFPSLL 602

  Fly   546 YKDFKDVASCVHGQKSLDHFGIICRELNNDGYIGYVFKCQSEHVCDDIVAAIAQAFDTCAEQKKK 610
                  :..|         ||:    |.:.|.|                  :.||
Mosquito   603 ------IERC---------FGV----LLSPGRI------------------VRQA---------- 620

  Fly   611 QDTQIFSCEHCPMLWYHKLCTDVEGLSEKKTQALILRRIETLSDDEQEIVWAKFCGSEKTN---S 672
             |.|:..   ...:.|.|   ..||            .....|........:..||...|.   |
Mosquito   621 -DMQLLD---MVSMGYVK---PPEG------------NAPASSGTGNNAASSSSCGGANTTGGAS 666

  Fly   673 PVAEQNQFLMMLLRAHCESRQQRHVHDTAENRSEFLNQYLGGSTIFMKAKRSLTNSFDNLLKRKP 737
            .||....|.....:...|.:         .|..|.||        ....|::||.:.|.::|
Mosquito   667 GVASGANFSQFPYQIKAEWK---------ANAFEPLN--------METPKKALTVAVDLVIK--- 711

  Fly   738 SKDDIAVPSHNLRDIREGSAEPLGTQSPPEGFRSRSNTVGASPSSK-----PTAEQLKSP-MMDI 796
                                   |.|.|   .|....|..|..|..     |.....|.| ::..
Mosquito   712 -----------------------GIQEP---VRFVIETCVAILSQSELRIVPNMFSNKRPLLLHF 750

  Fly   797 FIKVGNSPKEAETHQGSWRQAIL---NSVVTPS----------------------------KGLD 830
            ::.:      .|..:|:|....:   :.:|.|.                            :..|
Mosquito   751 YLTL------RENGEGTWEVDSIDHSDEIVEPQAPSAASSLSLNFNFKNWTFRNSASVQSMQDFD 809

  Fly   831 SEVPTEFLSPMRKPAKRGKRDAAELRELWRTAIRQTIMLNRMETENAMLQARQNENELKRIKLDY 895
            ...||::.|...:|...|..:.::
Mosquito   810 DPSPTDYSSDGDEPLLSGTGEVSK----------------------------------------- 833

  Fly   896 EEIVPCDKQLIERWEQIIERNSTQIGNKKDPKVLGHAIRTGVPRSKRGDVWTFLAEQHSMNTAPV 960
                .|....::.|:.||. ...|.|.::.||.|...:|.|:|...|..:|..||...:.
Mosquito   834 ----NCSAAQLDEWQGIIV-EWYQEGPERRPKNLPALVRMGIPEPLRATIWQRLACVENR----- 888

  Fly   961 DTKRFPNFNTPYHMLLKHLTEHQHAIFIDLGRTFPNHQFYKDPLGLGQLSLFNLLKAYSILDPEL 1025
             |:.|.:    |.:|:...|..:..|..|:.||||.|:|:|:..|.||.:|:.:.|||::.|.|:
Mosquito   889 -TEMFDS----YRVLITKETSCESVIQRDINRTFPAHKFFKENGGTGQENLYKVSKAYAVYDTEV 948

  Fly  1026 GYCQGLGFICGVLLLHCDEANSFQLLKHLMFRRNMRTKYLPDMKKFQLQLYQLSRLVKDHLPDLY 1090
            ||||||.||...||||..|..:|.:|..||:...:|..|....:...|:||||:||:||.|||||
Mosquito   949 GYCQGLSFIAASLLLHMPEEQAFCVLVALMYNYGLRDMYKMGFESLYLRLYQLNRLMKDQLPDLY 1013

  Fly  1091 VWLDQNDVSPTLYAAPWILTVFSSQFPLGFVARVFDLLFLESSDVIFKFAIALLSVHKQQLLAKD 1155
            ....|..|...::|:.|.||:|:::|||.||..:.|:..|:...|:|:.|:.||||.::.||..|
Mosquito  1014 EHFAQMGVESHMFASQWFLTLFTARFPLYFVFYILDVFLLDGIPVLFQVALTLLSVCRKDLLELD 1078

  Fly  1156 NFEEIMDYLKTVVPK--MEHTCMEQIMKLVFSMDIGKQLAEYKVEY------------------- 1199
             ||.|:.|.:..:||  ...|..:::|||.|...: |:|.:|::||
Mosquito  1079 -FEGILKYFRVTLPKKCRSETQAKKLMKLSFECKV-KKLKKYELEYLAKKEETERKEQELKQYEQ 1141

  Fly  1200 ------NVLQEEITTTNHHLEMLNREKTQNQHLEQQLQFAQSSIAQLETTRSSQQAQITTLQSQV 1258
                  ..||:||...|..:|.:.||..:|..:.|..:    .|.|      .|:|:...|.:.:
Mosquito  1142 RYGEERTKLQQEIVALNEKIEAMAREDRKNAGIIQDYK----RIIQ------RQEAENGKLHTML 1196

  Fly  1259 QSLELTIQTLGRYVGQLVEHNPDLELPNEVRRMLQQLDDLDRQRRKPIFTER--------KIGKS 1315
            ..|..||.|..:....:...:|..:...:.......:::.:.|:..|:.|::        ..||:
Mosquito  1197 DDLTKTISTCSKCTASIPHSSPLHKSYGKNFHQANTVNNNNEQQTHPLATDQPDGGSSAGTAGKN 1261

  Fly  1316 VSVNSHLG-----FPLKVLEELTERDELGSPQKQKKEKTPFFEQLRQQQQQHRLNGGGQSSNVGE 1375
            .:.::.:|     .||.:..:.....||...|.:..:..   .:.:.|...|:||
Mosquito  1262 AAPSAVIGGLGPLDPLVIASQRIRELELELAQTKLAQVE---AECKNQDLHHQLN---------- 1313

  Fly  1376 SGSPTPPSRPNRLLDNASARTVMQVKLDELKLPEHVDKFVANIKSPLEVDSGVGTPLSPPSTASN 1440
                               .||.:::.........:.|.:.:|:..:.....|..|  .|:..|.
Mosquito  1314 -------------------TTVTELQATRSSWQPWLSKTLNSIQEKVATKRDVNAP--APTFQSY 1357

  Fly  1441 SSGGSIFSRMGYRTTPPAL------SPLAQRQS 1467
            ::..:  |..|...|.|.:      :|||||.|
Mosquito  1358 ATTDA--SMKGNSNTLPHVRNNNNKTPLAQRHS 1388

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
plx	NP_001163511.1	PTB_TBC1D1_like	301..601	CDD:269967	66/349 (19%)
		DUF3350	831..880	CDD:463365	5/48 (10%)
		TBC	933..1152	CDD:214540	84/218 (39%)
		COG4372	<1190..>1353	CDD:443500	36/200 (18%)
GAPcenA	XP_061504472.1	None